Mouse IL-12/IL-23 p40 Non Allele-specific DuoSet, 15 Plate

• Reactivity: Mu
• Applications: ELISA
• Conjugate: Biotin

Mouse IL-12/IL-23 p40 Non Allele-specific DuoSet, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Il12b

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse IL-12/IL-23 p40 Non Allele-specific DuoSet, 15 Plate

• CLMF p40
• CLMF
• CLMF2
• Cytotoxic lymphocyte maturation factor 40 kDa subunit
• IL12 p40
• IL-12 p40
• IL-12 subunit p40
• IL12B
• IL-12B
• IL-12BNK cell stimulatory factor chain 2
• interleukin 12, p40
• interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocytematuration factor 2, p40)
• interleukin-12 beta chain
• interleukin-12 subunit beta
• natural killer cell stimulatory factor, 40 kD subunit
• NKSF
• NKSF2
• NKSF2IL12, subunit p40

Background

Interleukin 12 (IL-12), also known as natural killer cell stimulatory factor (NKSF) or cytotoxic lymphocyte maturation factor (CLMF), is a heterodimeric pleiotropic cytokine made up of a 40 kDa (p40) subunit and a 35 kDa (p35) subunit. The IL-12 p40 subunit is shared by IL-23, another heterodimeric cytokine that has biological activities similar to, as well as distinct from, IL-12. IL-12 is produced by macrophages and B cells and has been shown to have multiple effects on T cells and natural killer (NK) cells. While mouse IL-12 is active on both human and mouse cells, human IL-12 is not active on mouse cells.

Publications for IL-12/IL-23 p40 (DY2398)(14)

Publications using DY2398

• An, S;Oh, J;Shon, HJ;Song, J;Choi, YS;Kim, D; Co-adjuvanting Nod2-stimulating bacteria with a TLR7 agonist elicits potent protective immunity against respiratory virus infection International journal of antimicrobial agents 2024-10-28 [PMID: 39477030] (Mouse)
• Hering, M;Madi, A;Sandhoff, R;Ma, S;Wu, J;Mieg, A;Richter, K;Mohr, K;Knabe, N;Stichling, D;Poschet, G;Bestvater, F;Frank, L;Utikal, J;Umansky, V;Cui, G; Sphinganine recruits TLR4 adaptors in macrophages and promotes inflammation in murine models of sepsis and melanoma Nature communications 2024-07-18 [PMID: 39025856] (Mouse)
• J Wu, N Weisshaar, A Hotz-Wagen, A Madi, S Ma, A Mieg, M Hering, K Mohr, T Schlimbach, H Borgers, G Cui Skeletal muscle antagonizes antiviral CD8+ T cell exhaustion Sci Adv, 2020-06-12;6(24):eaba3458. 2020-06-12 [PMID: 32582853] (Mouse)
• A Napolitano, AG van der Ve, M Bunyan, A Borg, D Frith, S Howell, S Kjaer, A Beling, AP Snijders, KP Knobeloch, EM Frickel Cysteine-Reactive Free ISG15 Generates IL-1?-Producing CD8?+ Dendritic Cells at the Site of Infection J. Immunol., 2018-06-11;0(0):. 2018-06-11 [PMID: 29891555] (Mouse)
• MT Stier, K Goleniewsk, JY Cephus, DC Newcomb, TP Sherrill, KL Boyd, MH Bloodworth, ML Moore, K Chen, JK Kolls, RS Peebles STAT1 Represses Cytokine-Producing Group 2 and Group 3 Innate Lymphoid Cells during Viral Infection J. Immunol., 2017-06-02;0(0):. 2017-06-02 [PMID: 28576981] (Mouse)
• Malvicini M, Fiore E, Ghiaccio V, Piccioni F, Rizzo M, Olmedo Bonadeo L, Garcia M, Rodriguez M, Bayo J, Peixoto E, Atorrasagasti C, Alaniz L, Aquino J, Matar P, Mazzolini G Tumor Microenvironment Remodeling by 4-Methylumbelliferone Boosts the Antitumor Effect of Combined Immunotherapy in Murine Colorectal Carcinoma. Mol Ther, 2015-06-24;23(9):1444-55. 2015-06-24 [PMID: 26105158] (Mouse)
• Melo M, Nguyen Q, Cordeiro C, Hassan M, Yang N, McKell R, Rosowski E, Julien L, Butty V, Darde M, Ajzenberg D, Fitzgerald K, Young L, Saeij J Transcriptional analysis of murine macrophages infected with different Toxoplasma strains identifies novel regulation of host signaling pathways. PLoS Pathog, 2013-12-19;9(12):e1003779. 2013-12-19 [PMID: 24367253] (Mouse)
• Shaler C, Horvath C, McCormick S, Jeyanathan M, Khera A, Zganiacz A, Kasinska J, Stampfli M, Xing Z Continuous and discontinuous cigarette smoke exposure differentially affects protective Th1 immunity against pulmonary tuberculosis. PLoS ONE, 2013-03-19;8(3):e59185. 2013-03-19 [PMID: 23527127] (Mouse)
• Macedo GC, Magnani DM, Carvalho NB, Bruna-Romero O, Gazzinelli RT, Oliveira SC Central role of MyD88-dependent dendritic cell maturation and proinflammatory cytokine production to control Brucella abortus infection. J. Immunol., 2008-01-15;180(2):1080-7. 2008-01-15 [PMID: 18178848] (Mouse)
• Arias MA, Jaramillo G, Lopez YP, Mejia N, Mejia C, Pantoja AE, Shattock RJ, Garcia LF, Griffin GE Mycobacterium tuberculosis antigens specifically modulate CCR2 and MCP-1/CCL2 on lymphoid cells from human pulmonary hilar lymph nodes. J. Immunol., 2007-12-15;179(12):8381-91. 2007-12-15 [PMID: 18056384] (Human)
• Molle C, Nguyen M, Flamand V, Renneson J, Trottein F, De Wit D, Willems F, Goldman M, Goriely S IL-27 synthesis induced by TLR ligation critically depends on IFN regulatory factor 3. J. Immunol., 2007-06-15;178(12):7607-15. 2007-06-15 [PMID: 17548596] (Mouse)
• Fritz JH, Le Bourhis L, Sellge G, Magalhaes JG, Fsihi H, Kufer TA, Collins C, Viala J, Ferrero RL, Girardin SE, Philpott DJ Nod1-mediated innate immune recognition of peptidoglycan contributes to the onset of adaptive immunity. Immunity, 2007-04-12;26(4):445-59. 2007-04-12 [PMID: 17433730] (Mouse)
• Robertson SA, Care AS, Skinner RJ Interleukin 10 regulates inflammatory cytokine synthesis to protect against lipopolysaccharide-induced abortion and fetal growth restriction in mice. Biol. Reprod., 2007-01-10;76(5):738-48. 2007-01-10 [PMID: 17215490] (Mouse)
• Robertson SA, Skinner RJ, Care AS Essential role for IL-10 in resistance to lipopolysaccharide-induced preterm labor in mice. J. Immunol., 2006-10-01;177(7):4888-96. 2006-10-01 [PMID: 16982931] (Mouse)

Bioinformatics

• Gene Symbol: Il12b