Mouse IL-11 DuoSet ELISA, 15 Plate

• Reactivity: Mu
• Applications: ELISA
• Conjugate: Biotin

Mouse IL-11 DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Il11

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse IL-11 DuoSet ELISA, 15 Plate

• Adipogenesis inhibitory factor
• AGIF
• AGIFoprelvekin
• IL11
• IL-11
• IL-11Oprelvekin
• interleukin 11
• interleukin-11
• Oprelvekin

Background

Interleukin-11, also known as AGIF, is a pleiotropic cytokine in the IL-6 family, which also includes LIF, CNTF, Oncostatin M, Cardiotrophin-1, IL-27, and IL-31. It is secreted by osteoblasts, synoviocytes, fibroblasts, chondrocytes, intestinal myofibroblasts, and trophoblasts. It is found in the plasma mainly during inflammation, and is considered to be primarily anti-inflammatory. It stimulates hematopoiesis and thrombopoiesis, regulates macrophage differentiation, and confers mucosal protection in the intestine. It has also been found to enhance T cell polarization toward Th2, promote B cell IgG production, increase osteoclast bone absorption, protect endothelial cells from oxidative stress, and regulate epithelial proliferation and apoptosis. IL-11 signals through a receptor complex that contains IL-11 R alpha and gp130. A soluble form of IL-11 R alpha can bind IL-11 and either form a signaling complex with gp130 on the cell surface or inhibit cell surface IL-11 R alpha/gp130 signaling.

Publications for IL-11 (DY418)(13)

Publications using DY418

• Ichim, TE;Lopes, G;Reznik, R;Bykoriz, V;Fortunati, CA;Pascual, KA;Minev, B;Ramos, RA;Bajnath, A;Lin, E;Hu, J;Marincola, FM;Rath, A;Reznik, BN; Reduction of solid tumors by senescent cell immunization Journal of translational medicine 2025-11-28 [PMID: 41316207] (Mouse)
• Tang, T;Yang, T;Xue, H;Liu, X;Yu, J;Liang, C;Li, D;Xiang, C;Zheng, J;Wei, L;Ma, B; Breast cancer stem cell-derived exosomal lnc-PDGFD induces fibroblast-niche formation and promotes lung metastasis Oncogene 2024-12-04 [PMID: 39633064] (Mouse)
• Singh, A;Cho, WJ;Pulimamidi, VK;Mittal, SK;Chauhan, SK; Interleukin-11 Suppresses Ocular Surface Inflammation and Accelerates Wound Healing Investigative ophthalmology & visual science 2023-11-01 [PMID: 37910094] (Human)
• J Dong, WW Lim, SG Shekeran, J Tan, SY Lim, JWT Goh, BL George, S Schafer, SA Cook, AA Widjaja Hepatocyte Specific gp130 Signalling Underlies APAP Induced Liver Injury International Journal of Molecular Sciences, 2022-06-25;23(13):. 2022-06-25 [PMID: 35806094] (Mouse)
• J Dong, S Viswanatha, E Adami, BK Singh, SP Chothani, B Ng, WW Lim, J Zhou, M Tripathi, NSJ Ko, SG Shekeran, J Tan, SY Lim, M Wang, PM Lio, PM Yen, S Schafer, SA Cook, AA Widjaja Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH Nature Communications, 2021-01-04;12(1):66. 2021-01-04 [PMID: 33397952] (Mouse)
• T Kondratiev, M Shleeva, M Kapina, E Rubakova, I Linge, A Dyatlov, E Kondratiev, A Kaprelyant, A Apt Prolonged infection triggered by dormant Mycobacterium tuberculosis: Immune and inflammatory responses in lungs of genetically susceptible and resistant mice PLoS ONE, 2020-09-24;15(9):e0239668. 2020-09-24 [PMID: 32970762] (Mouse)
• CL Sanchez, SG Sims, JD Nowery, GP Meares Endoplasmic reticulum stress differentially modulates the IL-6 family of cytokines in murine astrocytes and macrophages Sci Rep, 2019-10-17;9(1):14931. 2019-10-17 [PMID: 31624329] (Mouse)
• X Zhang, N Kiapour, S Kapoor, T Khan, M Thamilaras, Y Tao, S Cohen, R Miller, RA Sobel, S Markovic-P IL-11 Induces Encephalitogenic Th17 Cells in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis J. Immunol., 2019-07-24;0(0):. 2019-07-24 [PMID: 31341075] (Mouse)
• N Sanadgol, F Golab, Z Tashakkor, N Taki, S Moradi Kou, A Mostafaie, M Mehdizadeh, M Abdollahi, G Taghizadeh, M Sharifzade Neuroprotective effects of ellagic acid on cuprizone-induced acute demyelination through limitation of microgliosis, adjustment of CXCL12/IL-17/IL-11 axis and restriction of mature oligodendrocytes apoptosis Pharm Biol, 2017-12-01;55(1):1679-1687. 2017-12-01 [PMID: 28447514] (Mouse)
• Hiroyasu Nakano Critical contribution of nuclear factor erythroid 2-related factor 2 (NRF2) to electrophile-induced Interleukin-11 production J. Biol. Chem., 2016-11-21;0(0):. 2016-11-21 [PMID: 27872193] (Mouse)
• Figueiredo C, Drohomyrecky P, McCarthy S, Leontyev D, Ma X, Branch D, Dunn S Optimal attenuation of experimental autoimmune encephalomyelitis by intravenous immunoglobulin requires an intact interleukin-11 receptor. PLoS ONE, 2014-07-31;9(7):e101947. 2014-07-31 [PMID: 25078447] (Mouse)
• Cho N, Nguyen DH, Satkunendrarajah K, Branch DR, Fehlings MG Evaluating the role of IL-11, a novel cytokine in the IL-6 family, in a mouse model of spinal cord injury. J Neuroinflammation, 2012-06-20;9(1):134. 2012-06-20 [PMID: 22715999] (Mouse)
• Chalaris A, Adam N, Sina C, Rosenstiel P, Lehmann-Koch J, Schirmacher P, Hartmann D, Cichy J, Gavrilova O, Schreiber S, Jostock T, Matthews V, Hasler R, Becker C, Neurath MF, Reiss K, Saftig P, Scheller J, Rose-John S Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice. J. Exp. Med., 2010-07-05;207(8):1617-24. 2010-07-05 [PMID: 20603312] (Mouse)

FAQs for IL-11 (DY418). (Showing 1 - 1 of 1 FAQs).

1. What is the difference between the Quantikine and Duoset ELISA kits?
   • Our Quantikine kits are fully optimized and validated for the sample types listed on the product specific webpage and datasheet, as this can vary between kits. Each kit is supplied ready to use with one pre-coated 96-well plate, a detection antibody directly conjugated to HRP, and all other necessary reagents. These kits are ideal for researchers who want the convenience of a ready to use and optimized ELISA product. Some of these kits are also available prepackaged in larger 6 and 50 plate sizes.Our DuoSet Kits, in contrast, are ELISA development kits containing the capture and detection antibody, the mass-value calibrated standard, and streptavidin-HRP to prepare approximately 5 or 15 plates. Ancillary reagents will need to be used/purchased, and for most kits, we will recommend one of our Ancillary Reagent Kits, which contain the reagents we use ourselves in-house. DuoSet kits are validated only for cell culture supernatant samples and therefore require further development and validation for accurate measurement in more complex samples such as serum and plasma. Our DuoSet Kits offer an economical, flexible alternative for the experienced ELISA user.

Bioinformatics

• Gene Symbol: Il11