Mouse IL-1 beta/IL-1F2 DuoSet ELISA, 15 Plate

Exosomal release of IL-1 alpha by neutrophils(A) Representative confocal images of peritoneal neutrophils stimulated with LPS or curdlan for 6 h.(B) Quantification of IL-1 alpha and CD63 co-localization using ImageJ (each data point represents a single cell).(C) NTA of EV size distribution and concentration.(D–G) Neutrophils were stimulated in the presence of exosome inhibitor GW4869, and IL-1 alpha and IL-1 beta were quantified by ELISA in isolated EVs following lysis (D and F) and in total cell-free supernatants (E and G).(H) Inhibition of EV secretion shown by NTA.(I) Bioactive IL-1 signaling through IL-1R1 reporter cells was measured in isolated exosomes in the absence of detergent lysis (n = 4). Neutralizing antibodies (Abs) to IL-1 alpha , IL-1 beta , or both cytokines were included in the reporter assay, and bioactive cytokine concentration was calculated based on a standard curve using recombinant IL-1 alpha and IL-1 beta .Two-way ANOVA with Tukey’s multiple comparisons test. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. Experiments in (A) and (B) were repeated three times; (C)–(G) are biological replicates from repeat experiments. Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/34010648), licensed under a CC-BY license. Not internally tested by R&D Systems.

Exosomal release of IL-1 alpha by neutrophils(A) Representative confocal images of peritoneal neutrophils stimulated with LPS or curdlan for 6 h.(B) Quantification of IL-1 alpha and CD63 co-localization using ImageJ (each data point represents a single cell).(C) NTA of EV size distribution and concentration.(D–G) Neutrophils were stimulated in the presence of exosome inhibitor GW4869, and IL-1 alpha and IL-1 beta were quantified by ELISA in isolated EVs following lysis (D and F) and in total cell-free supernatants (E and G).(H) Inhibition of EV secretion shown by NTA.(I) Bioactive IL-1 signaling through IL-1R1 reporter cells was measured in isolated exosomes in the absence of detergent lysis (n = 4). Neutralizing antibodies (Abs) to IL-1 alpha , IL-1 beta , or both cytokines were included in the reporter assay, and bioactive cytokine concentration was calculated based on a standard curve using recombinant IL-1 alpha and IL-1 beta .Two-way ANOVA with Tukey’s multiple comparisons test. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. Experiments in (A) and (B) were repeated three times; (C)–(G) are biological replicates from repeat experiments. Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/34010648), licensed under a CC-BY license. Not internally tested by R&D Systems.

Exosomal release of IL-1 alpha by neutrophils(A) Representative confocal images of peritoneal neutrophils stimulated with LPS or curdlan for 6 h.(B) Quantification of IL-1 alpha and CD63 co-localization using ImageJ (each data point represents a single cell).(C) NTA of EV size distribution and concentration.(D–G) Neutrophils were stimulated in the presence of exosome inhibitor GW4869, and IL-1 alpha and IL-1 beta were quantified by ELISA in isolated EVs following lysis (D and F) and in total cell-free supernatants (E and G).(H) Inhibition of EV secretion shown by NTA.(I) Bioactive IL-1 signaling through IL-1R1 reporter cells was measured in isolated exosomes in the absence of detergent lysis (n = 4). Neutralizing antibodies (Abs) to IL-1 alpha , IL-1 beta , or both cytokines were included in the reporter assay, and bioactive cytokine concentration was calculated based on a standard curve using recombinant IL-1 alpha and IL-1 beta .Two-way ANOVA with Tukey’s multiple comparisons test. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. Experiments in (A) and (B) were repeated three times; (C)–(G) are biological replicates from repeat experiments. Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/34010648), licensed under a CC-BY license. Not internally tested by R&D Systems.

Exosomal release of IL-1 alpha by neutrophils(A) Representative confocal images of peritoneal neutrophils stimulated with LPS or curdlan for 6 h.(B) Quantification of IL-1 alpha and CD63 co-localization using ImageJ (each data point represents a single cell).(C) NTA of EV size distribution and concentration.(D–G) Neutrophils were stimulated in the presence of exosome inhibitor GW4869, and IL-1 alpha and IL-1 beta were quantified by ELISA in isolated EVs following lysis (D and F) and in total cell-free supernatants (E and G).(H) Inhibition of EV secretion shown by NTA.(I) Bioactive IL-1 signaling through IL-1R1 reporter cells was measured in isolated exosomes in the absence of detergent lysis (n = 4). Neutralizing antibodies (Abs) to IL-1 alpha , IL-1 beta , or both cytokines were included in the reporter assay, and bioactive cytokine concentration was calculated based on a standard curve using recombinant IL-1 alpha and IL-1 beta .Two-way ANOVA with Tukey’s multiple comparisons test. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. Experiments in (A) and (B) were repeated three times; (C)–(G) are biological replicates from repeat experiments. Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/34010648), licensed under a CC-BY license. Not internally tested by R&D Systems.

• Reactivity: Mu
• Applications: ELISA
• Conjugate: Biotin

Mouse IL-1 beta/IL-1F2 DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Il1b

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse IL-1 beta/IL-1F2 DuoSet ELISA, 15 Plate

• catabolin
• IL1 beta
• IL-1 beta
• IL-1
• IL1B
• IL-1b
• IL1-BETA
• IL-1F2
• IL1F2IL-1 beta
• interleukin 1, beta
• interleukin-1 beta
• preinterleukin 1 beta
• pro-interleukin-1-beta

Background

The Interleukin 1 (IL-1) family of proteins consists of IL-1 alpha , IL-1 beta , and the IL-1 receptor antagonist (IL-1ra). IL-1 alpha and IL-1 beta bind to the same cell surface receptors and share biological functions (1). IL-1 is not produced by unstimulated cells of healthy individuals with the exception of skin keratinocytes, some epithelial cells, and certain cells of the central nervous system. However, in response to inflammatory agents, infections, or microbial endotoxins, a dramatic increase in the production of IL-1 by macrophages and various other cell types is seen. IL-1 beta plays a central role in immune and inflammatory responses, bone remodeling, fever, carbohydrate metabolism, and GH/IGF-I physiology. Inappropriate or prolonged production of IL-1 has been implicated in a variety of pathological conditions including sepsis, rheumatoid arthritis, inflammatory bowel disease, acute and chronic myelogenous leukemia, insulindependent diabetes mellitus, atherosclerosis, neuronal injury, and aging-related diseases (2-5). 

 IL-1 alpha and IL-1 beta are structurally related polypeptides that show approximately 25% homology at the amino acid (aa) level. Both are synthesized as 31 kDa precursors that are subsequently cleaved into mature proteins of approximately 17.5 kDa (6, 7). Cleavage of the IL-1 beta precursor by Caspase-1/ICE is a key step in the inflammatory response (2, 8). Neither IL-1 alpha nor IL-1 beta contains a typical hydrophobic signal peptide (9-11), but evidence suggests that these factors can be secreted by non-classical pathways (12, 13). A portion of unprocessed IL-1 alpha can be presented on the cell membrane and may retain biological activity (14). The precursor form of IL-1 beta , unlike the IL-1 alpha precursor, shows little or no biological activity in comparison to the processed form (13, 15). Both unprocessed and mature forms of IL-1 beta are exported from the cell. 

 IL-1 alpha and IL-1 beta exert their effects through immunoglobulin superfamily receptors that additionally bind IL-1ra. The 80 kDa transmembrane type I receptor (IL-1 RI) is expressed on T cells, fibroblasts, keratinocytes, endothelial cells, synovial lining cells, chondrocytes, and hepatocytes (16, 17). The 68 kDa transmembrane type II receptor (IL-1 RII) is expressed on B cells, neutrophils, and bone marrow cells (18). The two IL-1 receptor types show approximately 28% homology in their extracellular domains but differ significantly in that the type II receptor has a cytoplasmic domain of only 29 aa, whereas the type I receptor has a 213 aa cytoplasmic domain. IL-1 RII does not appear to signal in response to IL-1 and may function as a decoy receptor that attenuates IL-1 function (19). The IL-1 receptor accessory protein (IL-1 RAcP) associates with IL-1 RI and is required for IL-1 RI signal transduction (20). IL-1ra is a secreted molecule that functions as a competitive inhibitor of IL-1 (21, 22). Soluble forms of both IL-1 RI and IL-1 RII have been detected in human plasma, synovial fluids, and the conditioned media of several human cell lines (23, 24). In addition, IL-1 binding proteins that resemble soluble IL-1 RII are encoded by vaccinia and cowpox viruses (25).

Publications for IL-1 beta/IL-1F2 (DY401)(547)

Publications using DY401

• Fabrik, I;Spidlova, P;Prchal, L;Fabrikova, D;Viduka, I;Marecic, V;Filimonenko, V;Sleha, R;Vajrychova, M;Kupcik, R;Soukup, O;Rousar, T;Härtlova, A;Santic, M;Stulik, J; Glutamate utilization fuels rapid production of mitochondrial ROS in dendritic cells and drives systemic inflammation during tularemia Science advances 2025-08-29 [PMID: 40880474] (Mouse)
• Tanaka, Y;Takahashi, Y;Shindo, Y;Pitstick, LB;Teitelbaum, SL;Zou, W;Wang, X;Woods, J;Wikenheiser-Brokamp, KA;McCormack, FX; Hydroxyapatite microspheres induce durable pleurodesis and are rapidly cleared by pleural osteoclasts JCI insight 2025-08-21 [PMID: 40857249] (Mouse)
• Jeong, SH;Jung, J;Park, YJ;Lee, SJ;Lee, SJ; The Influence of polycyclic aromatic hydrocarbons exposure on the gut microbiome composition and inflammatory responses Ecotoxicology and environmental safety 2025-08-21 [PMID: 40848419] (Mouse)
• Wang, SY;Yen, WC;Chen, YP;Shiu, JS;Chen, MJ; Developing a Novel Fermented Milk with Anti-Aging and Anti-Oxidative Properties Using Lactobacillus kefiranofaciens HL1 and Lactococcus lactis APL015 Nutrients 2025-07-27 [PMID: 40806032] (Mouse)
• Speaks, S;Papa, J;McFadden, M;Roettger, JE;Liu, BD;Mohan, S;Reznik, BM;Leumi, S;Cable, JM;Forero, A;Yount, JS; Gasdermin E is Dispensable for H1N1 Influenza Virus Pathogenesis in Mice bioRxiv : the preprint server for biology 2025-07-29 [PMID: 40766393] (Mouse)
• Mank, MM;Zoller, KA;Fastiggi, VA;Ather, JL;Poynter, ME; Acidosis Licenses the NLRP3 Inflammasome-Inhibiting Effects of Beta-Hydroxybutyrate and Short-Chain Carboxylic Acids bioRxiv : the preprint server for biology 2025-05-07 [PMID: 40654769] (Mouse)
• Vardhanapu, M;Chaganti, PK;Ghosh, A;Mahale, A;Kulkarni, OP; Whole-body inhalation study of nanoparticle-enhanced vegetable oil metalworking fluids in mice for assessing occupational health risks Scientific reports 2025-07-01 [PMID: 40594334] (Mouse)
• Sakurai, K;Nakayama, S;Chubachi, S;Otake, S;Shimada, T;Irie, H;Tsutsumi, A;Kameyama, N;Hegab, AE;Shimoda, M;Hamamoto, J;Terai, H;Yasuda, H;Kanai, Y;Fukunaga, K; Roflumilast reduces the number of lung adenocarcinomas, inflammation, and emphysema in a smoking-induced mouse model BMC pulmonary medicine 2025-05-26 [PMID: 40420271] (Mouse)
• Tan, C;Kang, C;Liu, P;Sun, Y;Jin, H; Polystyrene nanoplastics exposure trigger cognitive impairment mitigated by luteolin modulated glucose-6-phosphate dehydrogenase/glutathione-dependent pathway Journal of hazardous materials 2025-04-24 [PMID: 40286667] (Mouse)
• Bonilha, CS;Veras, FP;Dos Santos Ramos, A;Gomes, GF;Rodrigues Lemes, RM;Arruda, E;Alves-Filho, JC;Cunha, TM;Cunha, FQ; PAD4 inhibition impacts immune responses in SARS-CoV-2 infection Mucosal immunology 2025-04-19 [PMID: 40258416] (Mouse)
• de Matos, RC;Bitencourt, AFA;Santana, PAL;de Oliveira, ADM;Inoue, TT;Machado, BC;Caldeira, ASP;Cunha Júnior, ADS;de Souza Moreira, CP;Scopel, M;Machado, RR; Phytochemical Profile and Biological Activities of the Hydroethanolic Extract of Pouteria guianensis: A Pharmacological Investigation Journal of ethnopharmacology 2025-04-15 [PMID: 40245965] (Mouse)
• Woods, PS;Cetin-Atalay, R;Meliton, AY;Sun, KA;Shamaa, OR;Shin, KWD;Tian, Y;Haugen, B;Hamanaka, RB;Mutlu, GM; HIF-1 regulates mitochondrial function in bone marrow-derived macrophages but not in tissue-resident alveolar macrophages Scientific reports 2025-04-04 [PMID: 40185846] (Mouse)
• Akinduro, O;Kumar, S;Chen, Y;Thomas, B;Hassan, Q;Sims, B; Human breast milk-derived exosomes attenuate lipopolysaccharide-induced activation in microglia Journal of neuroinflammation 2025-02-15 [PMID: 39955566] (Mouse)
• Watanabe, T;Hayashi, M;Arai, M;Matsushita, S;Handa, H;Kawano, M; Interferon-? production in response to the cytotoxic T lymphocyte epitope within an antigen incorporated in simian virus 40 virus-like particles Heliyon 2025-01-30 [PMID: 39897799] (Mouse)
• Lopez-Pascual, A;Santamaria, E;Ardaiz, N;Uriarte, I;Palmer, T;Graham, AR;Gomar, C;Barbero, RC;Latasa, MU;Arechederra, M;Urman, JM;Berasain, C;Fontanellas, A;Del Rio, CL;Fernandez-Barrena, MG;Martini, PGV;Schultz, JR;Berraondo, P;Avila, MA; FGF21 and APOA1 mRNA-based therapies for the treatment of experimental acute pancreatitis Journal of translational medicine 2025-01-27 [PMID: 39871339] (Human)
• Cook, PC;Brown, SL;Houlder, EL;Furlong-Silva, J;Conn, DP;Colombo, SAP;Baker, S;Svedberg, FR;Howell, G;Bertuzzi, M;Boon, L;Konkel, JE;Thornton, CR;Allen, JE;MacDonald, AS; Mgl2+ cDC2s coordinate fungal allergic airway type 2, but not type 17, inflammation in mice Nature communications 2025-01-22 [PMID: 39843887] (Mouse)
• Chan, FHM;Yeap, HW;Liu, Z;Rosli, SN;Low, KE;Bonne, I;Wu, Y;Chong, SZ;Chen, KW; Plasticity of cell death pathways ensures GSDMD activation during Yersinia pseudotuberculosis infection Cell reports 2025-01-16 [PMID: 39823227] (Mouse)
• Hamadi, N;Al?Salam, S;Beegam, S;Zaaba, N;Elzaki, O;Nemmar, A; Chronic Exposure to Two Regimens of Waterpipe Smoke Elicits Lung Injury, Genotoxicity, and Mitochondrial Impairment with the Involvement of MAPKs Activation in Mice International journal of molecular sciences 2025-01-06 [PMID: 39796284] (Mouse)
• Liu, J;Jiang, Y;Diao, Z;Chen, D;Xia, R;Wang, B;Yang, S;Yin, Z; Gasdermin D-mediated neutrophil pyroptosis drives inflammation in psoriasis eLife 2024-12-24 [PMID: 39717896] (Mouse, Transgenic Mouse)
• Becker, IC;Barrachina, MN;Lykins, J;Camacho, V;Stone, AP;Chua, BA;Signer, RAJ;Machlus, KR;Whiteheart, SW;Roweth, HG;Italiano, JE; Inhibition of RhoA-mediated secretory autophagy in megakaryocytes mitigates myelofibrosis in mice bioRxiv : the preprint server for biology 2024-12-05 [PMID: 39677616] (Mouse)
• Gonzales-Huerta, LE;Williams, TJ;Aljohani, R;Robertson, BD;Evans, CA;Armstrong-James, D; Precision-cut lung slices in air-liquid interface (PCLS-ALI): A novel ex-vivo model for the study of Pulmonary Aspergillosis bioRxiv : the preprint server for biology 2024-11-18 [PMID: 39605594] (Mouse)
• Wang, S;Hu, L;Fu, Y;Xu, F;Shen, Y;Liu, H;Zhu, L; Inhibition of IRE1?/XBP1 axis alleviates LPS-induced acute lung injury by suppressing TXNIP/NLRP3 inflammasome activation and ERK/p65 signaling pathway Respiratory research 2024-11-27 [PMID: 39604886] (Mouse)
• Clements, AN;Casillas, AL;Flores, CE;Liou, H;Toth, RK;Chauhan, SS;Sutterby, K;Deshmukh, SK;Wu, S;Xiu, J;Farrell, A;Radovich, M;Nabhan, C;Heath, EI;McKay, RR;Subah, N;Centuori, S;Wheeler, TJ;Cress, AE;Rogers, GC;Wilson, JE;Recio-Boiles, A;Warfel, NA; Inhibition of PIM kinase in tumor associated macrophages suppresses inflammasome activation and sensitizes prostate cancer to immunotherapy bioRxiv : the preprint server for biology 2024-10-24 [PMID: 39484473] (Transgenic Mouse)
• da Silva, CP;Silva, MDS;Santana, HM;Paloschi, MV;Ferreira E Ferreira, AA;Brilhante, LMV;Cruz, LF;Serrath, SN;Eulálio, MMC;Setúbal, SDS;Vallochi, AL;Nery, NM;Zuliani, JP; Bothrops atrox snake venom decreased MHC-II and CD86 expression in bone marrow-derived dendritic cells Acta tropica 2024-10-10 [PMID: 39393479] (Mouse)
• Romero, J;Toral-Rios, D;Yu, J;Paul, SM;Cashikar, AG; 25-hydroxycholesterol promotes brain cytokine production and leukocyte infiltration in a mouse model of lipopolysaccharide-induced neuroinflammation Journal of neuroinflammation 2024-10-05 [PMID: 39369253] (Mouse, Transgenic Mouse)
• Diercks, AH;Podolskaia, IS;Murray, TA;Jahn, AN;Mai, D;Liu, D;Amon, LM;Nakagawa, Y;Shimano, H;Aderem, A;Gold, ES; Oxysterol binding protein regulates the resolution of TLR-induced cytokine production in macrophages Proceedings of the National Academy of Sciences of the United States of America 2024-08-13 [PMID: 39361877] (Mouse)
• Rainer, H;Goretzki, A;Lin, YJ;Schiller, HR;Krause, M;Döring, S;Strecker, D;Junker, AC;Wolfheimer, S;Toda, M;Scheurer, S;Schülke, S; Characterization of the Immune-Modulating Properties of Different ?-Glucans on Myeloid Dendritic Cells International journal of molecular sciences 2024-09-13 [PMID: 39337403] (Mouse)
• de Oliveira, LD;de Carvalho, LS;Xavier, ACC;de Oliveira, FE;Leão, MVP;Diamantino, MGG;Khoury, RD;Valera, MC;Carvalho, CAT;Abu Hasna, A; In Vitro Evaluation of Sodium Hypochlorite, Chlorhexidine, Propolis, and Calcium Hydroxide Effect on Lipoteichoic-Acid-Induced Proinflammatory Cytokines Production Dentistry journal 2024-09-05 [PMID: 39329852] (Mouse)
• Nabukhotna, K;Kordus, SL;Shupe, JA;Cano Rodríguez, R;Smith, A;Bohannon, JK;Washington, MK;Lacy, DB; Purified CDT toxins and a clean deletion within the CDT locus provide novel insights into the contribution of binary toxin in cellular inflammation and Clostridioides difficile infection PLoS pathogens 2024-09-19 [PMID: 39298531] (Mouse)
• Klein, R;Onyuru, J;Viera, EM;Putnam, CD;Hoffman, HM;Hastings, ML; Modulating NLRP3 splicing with antisense oligonucleotides to control pathological inflammation bioRxiv : the preprint server for biology 2024-09-06 [PMID: 39282364] (Mouse)
• Nayer, B;Tan, JL;Alshoubaki, YK;Lu, YZ;Legrand, JMD;Lau, S;Hu, N;Park, AJ;Wang, XN;Amann-Zalcenstein, D;Hickey, PF;Wilson, T;Kuhn, GA;Müller, R;Vasanthakumar, A;Akira, S;Martino, MM; Local administration of regulatory T cells promotes tissue healing Nature communications 2024-09-09 [PMID: 39251592] (Mouse)
• Maruthupandy, M;Jeon, JH;Noh, J;Yang, SI;Cho, WS; Mitigated toxicity of polystyrene nanoplastics in combination exposure with copper ions by transformation into copper (I) oxide: Inhibits the oxidative potential of nanoplastics Chemosphere 2024-09-05 [PMID: 39243901] (Mouse)
• Honwad, HH;Najibi, M;Koscso, B;Bogunovic, M;Irazoqui, JE; TFEB-Mediated Pro-inflammatory Response in Murine Macrophages Induced by Acute Alpha7 Nicotinic Receptor Activation bioRxiv : the preprint server for biology 2024-08-10 [PMID: 39211236] (Mouse)
• Pinzan, CF;Valero, C;de Castro, PA;da Silva, JL;Earle, K;Liu, H;Horta, MAC;Kniemeyer, O;Krüger, T;Pschibul, A;Cömert, DN;Heinekamp, T;Brakhage, AA;Steenwyk, JL;Mead, ME;Hermsdorf, N;Filler, SG;da Rosa-Garzon, NG;Delbaje, E;Bromley, MJ;Cabral, H;Diehl, C;Angeli, CB;Palmisano, G;Ibrahim, AS;Rinker, DC;Sauters, TJC;Steffen, K;Gumilang, A;Rokas, A;Gago, S;Dos Reis, TF;Goldman, GH; Aspergillus fumigatus conidial surface-associated proteome reveals factors for fungal evasion and host immunity modulation Nature microbiology 2024-08-27 [PMID: 39191887] (Mouse)
• Wen, Z;Yuan, T;Liu, J;Wang, D;Ni, J;Yan, X;Tang, J;Tang, J;Wu, X;Wang, Z; Atg16l2 augments Nlrc4 inflammasome activation by facilitating NAIPs-NLRC4 association European journal of immunology 2024-08-22 [PMID: 39175123] (Mouse, Transgenic Mouse)
• Gabele, L;Bochow, I;Rieke, N;Sieben, C;Michaelsen-Preusse, K;Hosseini, S;Korte, M; H7N7 viral infection elicits pronounced, sex-specific neuroinflammatory responses in vitro Frontiers in cellular neuroscience 2024-08-07 [PMID: 39171200] (Mouse)
• Ohm, M;Hosseini, S;Lonnemann, N;He, W;More, T;Goldmann, O;Medina, E;Hiller, K;Korte, M; The potential therapeutic role of itaconate and mesaconate on the detrimental effects of LPS-induced neuroinflammation in the brain Journal of neuroinflammation 2024-08-20 [PMID: 39164713] (Mouse)
• Xu, J;Pickard, JM;Núñez, G; FDA-approved disulfiram inhibits the NLRP3 inflammasome by regulating NLRP3 palmitoylation Cell reports 2024-08-07 [PMID: 39116210] (Mouse)
• Map Schuh, C;Ezquer, F;Mamani, S;Campodónico, PR;Cárcamo, C;Martinez-Gómez, F;Aburto, I;Ezquer, M;Morales, B;Olivares, B; A Natural deep eutectic solvent as an effective material for dual debridement and antibiofilm effects in chronic wound treatment International journal of pharmaceutics 2024-08-03 [PMID: 39103063] (Mouse)
• Zou, Z;Singh, P;Pinkner, JS;Obernuefemann, CLP;Xu, W;Nye, TM;Dodson, KW;Almqvist, F;Hultgren, SJ;Caparon, MG; Dihydrothiazolo ring-fused 2-pyridone antimicrobial compounds treat Streptococcus pyogenes skin and soft tissue infection Science advances 2024-08-02 [PMID: 39093975] (Mouse)
• Abarikwu, SO;Coimbra, JLP;Campolina-Silva, G;Rocha, ST;Costa, VV;Lacerda, SMSN;Costa, GMJ; Acute effects of atrazine on the immunoexpressions of Sertoli and germ cells molecular markers, cytokines, chemokines, and sex hormones levels in mice testes and epididymides Chemosphere 2024-07-15 [PMID: 39019188] (Mouse)
• Rizzo, GP;Sanches, RC;Chavero, C;Bianchi, DS;Apuzzo, E;Herrera, SE;Agazzi, ML;Keitelman, IA;Trevani, AS;Oliveira, SC;Azzaroni, O;Smaldini, PL;Docena, GH; Poly(allylamine)-tripolyphosphate polymeric nanoparticle as an NLRP3-dependent systemic adjuvant for the vaccine development bioRxiv : the preprint server for biology 2024-07-04 [PMID: 39005275] (Mouse)
• Katsoulis, O;Toussaint, M;Jackson, MM;Mallia, P;Footitt, J;Mincham, KT;Meyer, GFM;Kebadze, T;Gilmour, A;Long, M;Aswani, AD;Snelgrove, RJ;Johnston, SL;Chalmers, JD;Singanayagam, A; Neutrophil extracellular traps promote immunopathogenesis of virus-induced COPD exacerbations Nature communications 2024-07-09 [PMID: 38982052] (Mouse)
• Kelly, AM;McCarthy, KN;Claxton, TJ;Carlile, SR;O'Brien, EC;Vozza, EG;Mills, KH;McLoughlin, RM; IL-10 inhibition during immunization improves vaccine-induced protection against Staphylococcus aureus infection JCI insight 2024-05-28 [PMID: 38973612] (Mouse)
• Yow, SJ;Rosli, SN;Hutchinson, PE;Chen, KW; Differential signalling requirements for RIPK1-dependent pyroptosis in neutrophils and macrophages Cell death & disease 2024-07-04 [PMID: 38965211] (Mouse, Transgenic Mouse)
• Salesse, L;Duval, A;Sauvanet, P;Da Silva, A;Barnich, N;Godfraind, C;Dalmasso, G;Nguyen, HTT; ATG16L1 in myeloid cells limits colorectal tumor growth in ApcMin/+ mice infected with colibactin-producing Escherichia coli via decreasing inflammasome activation Autophagy 2024-05-31 [PMID: 38818900] (Mouse)
• Alves, M;Gil, B;Villegas-Salmerón, J;Salari, V;Martins-Ferreira, R;Arribas Blázquez, M;Menéndez Méndez, A;Da Rosa Gerbatin, R;Smith, J;de Diego-Garcia, L;Conte, G;Sierra-Marquez, J;Merino Serrais, P;Mitra, M;Fernandez Martin, A;Wang, Y;Kesavan, J;Melia, C;Parras, A;Beamer, E;Zimmer, B;Heiland, M;Cavanagh, B;Parcianello Cipolat, R;Morgan, J;Teng, X;Prehn, JHM;Fabene, PF;Bertini, G;Artalejo, AR;Ballestar, E;Nicke, A;Olivos-Oré, LA;Connolly, NMC;Henshall, DC;Engel, T; Opposing effects of the purinergic P2X7 receptor on seizures in neurons and microglia in male mice Brain, behavior, and immunity 2024-05-20 [PMID: 38777288] (Transgenic Mouse)
• Zhu, W;Xu, X;Nagarajan, V;Guo, J;Peng, Z;Zhang, A;Liu, J;Mattapallil, MJ;Jittayasothorn, Y;Horai, R;Leger, AJS;Caspi, RR; TLR2 Supports ?? T cell IL-17A Response to ocular surface commensals by Metabolic Reprogramming bioRxiv : the preprint server for biology 2024-04-01 [PMID: 38712203] (Mouse)
• Lee, J;Kim, MY;Kim, HJ;Choi, WS;Kim, HS; Impaired autophagy in myeloid cells aggravates psoriasis-like skin inflammation through the IL-1?/CXCL2/neutrophil axis Cell & bioscience 2024-05-04 [PMID: 38704587] (Transgenic Mouse)
• Wang, Y;Gao, JZ;Sakaguchi, T;Maretzky, T;Gurung, P;Narayanan, NS;Short, S;Xiong, Y;Kang, Z; LRRK2 G2019S Promotes Colon Cancer Potentially via LRRK2-GSDMD Axis-Mediated Gut Inflammation Cells 2024-03-23 [PMID: 38607004] (Transgenic Mouse)
• Mingo, YB;Gabele, L;Lonnemann, N;Brône, B;Korte, M;Hosseini, S; The effects of urolithin A on poly I:C-induced microglial activation Frontiers in cellular neuroscience 2024-03-20 [PMID: 38577490] (Mouse)
• Zhang, N;Zhang, J;Yang, Y;Shan, H;Hou, S;Fang, H;Ma, M;Chen, Z;Tan, L;Xu, D; A palmitoylation-depalmitoylation relay spatiotemporally controls GSDMD activation in pyroptosis Nature cell biology 2024-03-27 [PMID: 38538834] (Mouse)
• Dai, F;Hu, C;Li, X;Zhang, Z;Wang, H;Zhou, W;Wang, J;Geng, Q;Dong, Y;Tang, C; Cav3.2 channel regulates cerebral ischemia/reperfusion injury: a promising target for intervention Neural regeneration research 2024-11-01 [PMID: 38526284] (Mouse)
• Zelek, WM;Bevan, RJ;Morgan, BP; Targeting terminal pathway reduces brain complement activation, amyloid load and synapse loss, and improves cognition in a mouse model of dementia Brain, behavior, and immunity 2024-03-12 [PMID: 38485063] (Mouse)
• Catalán, L;Carceller, M;Terencio, M;Alcaraz, M;Ferrándiz, M;Montesinos, M; Osteostatin Mitigates Gouty Arthritis through the Inhibition of Caspase-1 Activation and Upregulation of Nrf2 Expression International Journal of Molecular Sciences 2024-02-27 [PMID: 38474000] (Mouse)
• Koller, BH;Nguyen, M;Snouwaert, JN;Gabel, CA;Ting, JP; Species-specific NLRP3 regulation and its role in CNS autoinflammatory diseases Cell reports 2024-02-29 [PMID: 38427558] (Mouse)
• Kim, MY;Jeong, B;Lee, GS;Jeon, H;Yang, YM;Yang, H;Han, YH; Panaxydol extracted from Panax ginseng inhibits NLRP3 inflammasome activation to ameliorate NASH-induced liver injury International immunopharmacology 2024-01-22 [PMID: 38262161] (Mouse)
• Mills, KAM;Westermann, F;Espinosa, V;Rosiek, E;Desai, JV;Aufiero, MA;Guo, Y;Mitchell, KA;Tuzlak, S;De Feo, D;Lionakis, MS;Rivera, A;Becher, B;Hohl, TM; GM-CSF-mediated epithelial-immune cell crosstalk orchestrates pulmonary immunity to Aspergillus fumigatus bioRxiv : the preprint server for biology 2024-01-04 [PMID: 38260364] (Mouse)
• Zou, Z;Obernuefemann, CLP;Singh, P;Pinkner, JS;Xu, W;Nye, TM;Dodson, KW;Almqvist, F;Hultgren, SJ;Caparon, MG; Dihydrothiazolo ring-fused 2-pyridone antimicrobial compounds treat Streptococcus pyogenes skin and soft tissue infection bioRxiv : the preprint server for biology 2024-01-03 [PMID: 38260261] (Mouse)
• De, M;Sukla, S;Bharatiya, S;Keshri, S;Roy, DG;Roy, S;Dutta, D;Saha, S;Ejazi, SA;Ravichandiran, V;Ali, N;Chatterjee, M;Chinnaswamy, S; IFN-?3 is induced by Leishmania donovani and can inhibit parasite growth in cell line models but not in the mouse model, while it shows a significant association with leishmaniasis in humans Infection and immunity 2024-01-09 [PMID: 38193711] (Mouse)
• Grigsby, SJ;Prasad, GVRK;Wallach, JB;Mittal, E;Hsu, FF;Schnappinger, D;Philips, JA; CpsA mediates infection of recruited lung myeloid cells by Mycobacterium tuberculosis Cell reports 2023-12-19 [PMID: 38127624] (Mouse)
• Nakajima, S;Demers, G;Machuca-Parra, AI;Pour, ZD;Bairamian, D;Bouyakdan, K;Fisette, A;Kabahizi, A;Robb, J;Rodaros, D;Laurent, C;Ferreira, G;Arbour, N;Alquier, T;Fulton, S; Central activation of the fatty acid sensor GPR120 suppresses microglia reactivity and alleviates sickness- and anxiety-like behaviors Journal of neuroinflammation 2023-12-19 [PMID: 38111048] (Mouse)
• Morais, MÍ;Braga, AV;Silva, RRL;Barbosa, BCM;Costa, SOAM;Rodrigues, FF;Melo, ISF;Matos, RC;Carobin, NV;Sabino, AP;Coelho, MM;Machado, RR; Metformin inhibits paclitaxel-induced mechanical allodynia by activating opioidergic pathways and reducing cytokines production in the dorsal root ganglia and thalamus Cytokine 2023-12-14 [PMID: 38101167] (Mouse)
• Zhu, W;Han, L;Wu, Y;Tong, L;He, L;Wang, Q;Yan, Y;Pan, T;Shen, J;Song, Y;Shen, Y;Zhu, Q;Zhou, J; Keratin 15 protects against cigarette smoke-induced epithelial mesenchymal transformation by MMP-9 Respiratory research 2023-11-25 [PMID: 38007424] (Mouse, Transgenic Mouse)
• Pereira, RDD;Rabelo, RAN;Oliveira, NFM;Porto, SLT;Andrade, ACDSP;Queiroz-Junior, CM;Barbosa, CLN;de Souza-Costa, LP;Santos, FRDS;Oliveira, FBR;da Silva, BLV;Umezu, HL;Ferreira, R;da Silva, GSF;Cruz, JS;Teixeira, MM;Costa, VV;Machado, FS; A 5-Lipoxygenase Inhibitor, Zileuton, Modulates Host Immune Responses and Improves Lung Function in a Model of Severe Acute Respiratory Syndrome (SARS) Induced by Betacoronavirus Viruses 2023-10-04 [PMID: 37896826] (Mouse)
• Meibers, HE;Warrick, KA;VonHandorf, A;Vallez, CN;Kawarizadeh, K;Saha, I;Donmez, O;Jain, VG;Kottyan, LC;Weirauch, MT;Pasare, C; Effector memory T cells induce innate inflammation by triggering DNA damage and a non-canonical STING pathway in dendritic cells Cell reports 2023-09-27 [PMID: 37794597] (Mouse)
• Goldman, G;Valero, C;Pinzan, C;de Castro, P;van Rhijn, N;Earle, K;Liu, H;Horta, MA;Kniemeyer, O;Kruger, T;Pschibul, A;Coemert, D;Heinekamp, T;Brakhage, A;Steenwyk, J;Mead, M;Rokas, A;Filler, S;da Rosa-Garzon, N;Delbaje, E;Bromley, M;Angeli, C;Palmisano, G;Ibrahim, A;Gago, S;Reis, TD; A phylogenetic approach to explore the Aspergillus fumigatus conidial surface-associated proteome and its role in pathogenesis Research square 2023-09-18 [PMID: 37790311] (Mouse)
• Wong, MP;Juan, EYW;Chelluri, SS;Wang, P;Pahmeier, F;Castillo-Rojas, B;Blanc, SF;Biering, SB;Vance, RE;Harris, E; The Inflammasome Pathway is Activated by Dengue Virus Non-structural Protein 1 and is Protective During Dengue Virus Infection bioRxiv : the preprint server for biology 2023-09-21 [PMID: 37790301] (Mouse)
• Ribeiro, R;Silva, EG;Moreira, FC;Gomes, GF;Cussat, GR;Silva, BSR;da Silva, MCM;de Barros Fernandes, H;de Sena Oliveira, C;de Oliveira Guarnieri, L;Lopes, V;Ferreira, CN;de Faria, AMC;Maioli, TU;Ribeiro, FM;de Miranda, AS;Moraes, GSP;de Oliveira, ACP;Vieira, LB; Chronic hyperpalatable diet induces impairment of hippocampal-dependent memories and alters glutamatergic and fractalkine axis signaling Scientific reports 2023-09-29 [PMID: 37773430] (Mouse)
• Talley, S;Rademacher, DJ;Campbell, EM; Inflammasome activation occurs in CD4+ and CD8+ T cells during graft-versus-host disease Cell death & disease 2023-09-25 [PMID: 37749127] (Mouse)
• Joo, MK;Shin, YJ;Kim, DH; Cefaclor causes vagus nerve-mediated depression-like symptoms with gut dysbiosis in mice Scientific reports 2023-09-19 [PMID: 37726354] (Mouse)
• Fechtner, S;Allen, BE;Chriswell, ME;Jubair, WK;Robertson, CE;Kofonow, JN;Frank, DN;Holers, VM;Kuhn, KA; 3,3-dimethyl-1-butanol and its metabolite 3,3-dimethylbutyrate ameliorate collagen-induced arthritis independent of choline trimethylamine lyase activity Research square 2023-09-05 [PMID: 37720032] (Mouse)
• Beltran-Lobo, P;Hughes, MM;Troakes, C;Croft, CL;Rupawala, H;Jutzi, D;Ruepp, MD;Jimenez-Sanchez, M;Perkinton, MS;Kassiou, M;Golde, TE;Hanger, DP;Verkhratsky, A;Perez-Nievas, BG;Noble, W; P2X7R influences tau aggregate burden in human tauopathies and shows distinct signalling in microglia and astrocytes Brain, behavior, and immunity 2023-09-15 [PMID: 37716378] (Mouse)
• Membrane-bound Interleukin-1 alpha mediates leukocyte adhesion during atherogenesis [PMID: 37701434] (Mouse)
• Valero, C;Pinzan, CF;de Castro, PA;van Rhijn, N;Earle, K;Liu, H;Horta, MAC;Kniemeyer, O;Krüger, T;Pschibul, A;Coemert, DN;Heinekamp, T;Brakhage, AA;Steenwyk, JL;Mead, ME;Rokas, A;Filler, SG;da Rosa-Garzon, NG;Cabral, H;Deljabe, E;Bromley, MJ;Angeli, CB;Palmisano, G;Ibrahim, AS;Gago, S;Dos Reis, TF;Goldman, GH; A phylogenetic approach to explore the Aspergillus fumigatus conidial surface-associated proteome and its role in pathogenesis bioRxiv : the preprint server for biology 2023-08-22 [PMID: 37662192] (Mouse)
• Kaur, M;Buyck, JM;Goormaghtigh, F;Decout, JL;Mozaheb, N;Mingeot-Leclercq, MP; Deficient P. aeruginosa in MlaA/VacJ outer membrane lipoprotein shows decrease in rhamnolipids secretion, motility, and biofilm formation, and increase in fluoroquinolones susceptibility and innate immune response Research in microbiology 2023-09-01 [PMID: 37660742] (Human)
• Schädel, P;Wichmann-Costaganna, M;Czapka, A;Gebert, N;Ori, A;Werz, O; Short-Term Caloric Restriction and Subsequent Re-Feeding Compromise Liver Health and Associated Lipid Mediator Signaling in Aged Mice Nutrients 2023-08-21 [PMID: 37630850] (Mouse)
• Torazza, C;Provenzano, F;Gallia, E;Cerminara, M;Balbi, M;Bonifacino, T;Tessitore, S;Ravera, S;Usai, C;Musante, I;Puliti, A;Van Den Bosch, L;Jafar-Nejad, P;Rigo, F;Milanese, M;Bonanno, G; Genetic Downregulation of the Metabotropic Glutamate Receptor Type 5 Dampens the Reactive and Neurotoxic Phenotype of Adult ALS Astrocytes Cells 2023-07-27 [PMID: 37566031] (Mouse)
• Yang, Y;Gao, ZF;Hou, GG;Meng, QG;Hou, Y; Discovery of anti-neuroinflammatory agents from 1,4,5,6-tetrahydrobenzo[2,3]oxepino[4,5-d]pyrimidin-2-amine derivatives by regulating microglia polarization European journal of medicinal chemistry 2023-11-05 [PMID: 37544188] (Mouse)
• Yang, Y;Gao, ZF;Hou, GG;Meng, QG;Hou, Y; Discovery of anti-neuroinflammatory agents from 1,4,5,6-tetrahydrobenzo[2,3]oxepino[4,5-d]pyrimidin-2-amine derivatives by regulating microglia polarization European journal of medicinal chemistry 2023-11-05 [PMID: 37544188]
• Khushali Patel, Jasmine Nguyen, Sumaiyah Shaha, Amy Brightwell, Wendy Duan, Ashley Zubkowski et al. Loss of polarity regulators initiates gasdermin-E-mediated pyroptosis in syncytiotrophoblasts Life Science Alliance 2023-10-01 [PMID: 37468163] (Human)
• Wang, Y;Gao, JZ;Sakaguchi, T;Maretzky, T;Gurung, P;Short, S;Xiong, Y;Kang, Z; LRRK2 G2019S promotes the development of colon cancer via modulating intestinal inflammation bioRxiv : the preprint server for biology 2023-06-30 [PMID: 37425755] (Mouse)
• Kobori, N;Moore, AN;Redell, JB;Dash, PK; Caudal DMN neurons innervate the spleen and release CART peptide to regulate neuroimmune function Journal of neuroinflammation 2023-07-04 [PMID: 37403174] (Mouse)
• Oummadi, A;Menuet, A;Méresse, S;Laugeray, A;Guillemin, G;Mortaud, S; The herbicides glyphosate and glufosinate and the cyanotoxin ?-N-methylamino-l-alanine induce long-term motor disorders following postnatal exposure: the importance of prior asymptomatic maternal inflammatory sensitization Frontiers in neuroscience 2023-06-09 [PMID: 37360165] (Mouse)
• Amo-Aparicio, J;Daly, J;Højen, JF;Dinarello, CA; Pharmacologic inhibition of NLRP3 reduces the levels of ?-synuclein and protects dopaminergic neurons in a model of Parkinson's disease Journal of neuroinflammation 2023-06-22 [PMID: 37349821] (Mouse)
• Shinde, P;Kiepas, A;Zhang, L;Sudhir, S;Konstantopoulos, K;Stamatos, NM; Polysialylation controls immune function of myeloid cells in murine model of pneumococcal pneumonia Cell reports 2023-06-19 [PMID: 37339052] (Mouse)
• Pinto, EP;da Costa, SOAM;D'Haese, C;Nysten, B;Machado, FP;Rocha, LM;de Souza, TM;Beloqui, A;Machado, RR;Araújo, RS; Poly-?-caprolactone nanocapsules loaded with copaiba essential oil reduce inflammation and pain in mice International journal of pharmaceutics 2023-06-17 [PMID: 37336298] (Mouse)
• Su, P;Wu, M;Yin, X;Li, M;Li, Y;Bai, M;Wang, B;Xu, E; Modified Xiaoyao San reverses lipopolysaccharide-induced depression-like behavior through suppressing microglia M1 polarization via enhancing autophagy involved in PI3K/Akt/mTOR pathway in mice Journal of ethnopharmacology 2023-05-30 [PMID: 37263314] (Mouse)
• Kim, TW; Fisetin, an Anti-Inflammatory Agent, Overcomes Radioresistance by Activating the PERK-ATF4-CHOP Axis in Liver Cancer International journal of molecular sciences 2023-05-22 [PMID: 37240422] (Mouse)
• Tarkany Basting, R;Henrique Napimoga, M;Ant�nio Trindade Silva, C;Ballassini Abdalla, H;Campos Durso, B;Henrique Barboza Martins, L;de Abreu Cavalcanti, H;Hammock, BD;Trindade Clemente-Napimoga, J; Soluble epoxide hydrolase inhibitor blockage microglial cell activation in subnucleus caudalis in a persistent model of arthritis International immunopharmacology 2023-05-23 [PMID: 37230034] (Mouse)
• Jack P. Green, Lina Y. El-Sharkawy, Stefan Roth, Jie Zhu, Jiayu Cao, Andrew G. Leach et al. Discovery of an inhibitor of DNA-driven inflammation that preferentially targets the AIM2 inflammasome iScience 2023-05-19 [PMID: 37216118] (Mouse)
• Weerasinghe, H;Simm, C;Djajawi, TM;Tedja, I;Lo, TL;Simpson, DS;Shasha, D;Mizrahi, N;Olivier, FAB;Speir, M;Lawlor, KE;Ben-Ami, R;Traven, A; Candida auris uses metabolic strategies to escape and kill macrophages while avoiding robust activation of the NLRP3 inflammasome response Cell reports 2023-05-18 [PMID: 37204928] (Mouse)
• Hamadi, N;Beegam, S;Zaaba, NE;Elzaki, O;Altamimi, MA;Nemmar, A; Neuroinflammation, Oxidative Stress, Apoptosis, Microgliosis and Astrogliosis in the Cerebellum of Mice Chronically Exposed to Waterpipe Smoke Biomedicines 2023-04-06 [PMID: 37189722] (Mouse)
• Nuta, GC;Gilad, Y;Goldberg, N;Meril, S;Bahlsen, M;Carvalho, S;Kozer, N;Barr, H;Fridmann Sirkis, Y;Herc�k, K;B?ehov�, P;Nencka, R;Bialik, S;Eisenstein, M;Kimchi, A; Identifying a selective inhibitor of autophagy that targets ATG12-ATG3 protein-protein interaction Autophagy 2023-02-22 [PMID: 37184247] (Mouse)
• Guo, Y;Gu, D;Huang, T;Li, A;Zhou, Y;Kang, X;Meng, C;Xiong, D;Song, L;Jiao, X;Pan, Z; Salmonella Enteritidis T1SS protein SiiD inhibits NLRP3 inflammasome activation via repressing the mtROS-ASC dependent pathway PLoS pathogens 2023-05-08 [PMID: 37155697] (Transgenic Mouse, Mouse)
• T Tominaga, J Huang, S Wang, M Noguchi, Y Tong, M Asano-Orit, K Suzuki Collagen-Derived Dipeptides and Amino Acids Have Immunomodulatory Effects in M1-Differentiated RAW264.7 Cells and PBMC International Journal of Molecular Sciences, 2023-04-08;24(8):. 2023-04-08 [PMID: 37108094] (Mouse)
• P Schädel, A Czapka, N Gebert, ID Jacobsen, A Ori, O Werz Metabololipidomic and proteomic profiling reveals aberrant macrophage activation and interrelated immunomodulatory mediator release during aging Aging Cell, 2023-04-26;0(0):e13856. 2023-04-26 [PMID: 37101405] (Mouse)
• H Liu, S Wang, L Gong, Y Shen, F Xu, Y Wang, L Hu, L Zhu SIRT6 ameliorates LPS-induced apoptosis and tight junction injury in ARDS through the ERK1/2 pathway and autophagy International Journal of Medical Sciences, 2023-03-05;20(5):581-594. 2023-03-05 [PMID: 37082736] (Mouse)
• J Chu, J Yang, Y Zhou, J Chen, KH Chen, C Zhang, HY Cheng, N Koylass, JO Liu, Y Guan, Z Qiu ATP-releasing SWELL1 channel in spinal microglia contributes to neuropathic pain Science Advances, 2023-03-29;9(13):eade9931. 2023-03-29 [PMID: 36989353] (Mouse)
• M Wang, D Xiong, X Wang, D Gu, C Meng, X Jiao, Z Pan The DNA adenine methylase of Salmonella Enteritidis promotes their intracellular replication by inhibiting arachidonic acid metabolism pathway in macrophages Frontiers in Microbiology, 2023-03-02;14(0):1080851. 2023-03-02 [PMID: 36937256] (Mouse)
• A Hooftman, CG Peace, DG Ryan, EA Day, M Yang, AF McGettrick, M Yin, EN Montano, L Huo, JE Toller-Kaw, V Zecchini, TAJ Ryan, A Bolado-Car, AM Casey, HA Prag, ASH Costa, G De Los San, M Ishimori, DJ Wallace, S Venuturupa, E Nikitopoul, N Frizzell, C Johansson, A Von Kriegs, MP Murphy, C Jefferies, C Frezza, LAJ O'Neill Macrophage fumarate hydratase restrains mtRNA-mediated interferon production Nature, 2023-03-08;615(7952):490-498. 2023-03-08 [PMID: 36890227] (Mouse)
• FL Fontes-Dan, GG Fernandes, EG Gutman, EV De Lima, LS Antonio, MB Hammerle, HP Mota-Arauj, LC Colodeti, SMB Araújo, GM Froz, TN da Silva, LA Duarte, AL Salvio, KL Pires, LAA Leon, CCF Vasconcelo, L Romão, LEB Savio, JL Silva, R da Costa, JR Clarke, AT Da Poian, SV Alves-Leon, GF Passos, CP Figueiredo SARS-CoV-2 Spike protein induces TLR4-mediated long-term cognitive dysfunction recapitulating post-COVID-19 syndrome in mice Cell Reports, 2023-02-17;42(3):112189. 2023-02-17 [PMID: 36857178] (Mouse)
• KK Jang, T Heaney, M London, Y Ding, F Yeung, D Ercelen, YH Chen, J Axelrad, S Gurunathan, A Marijke Ke, ME Griffin, HC Hang, K Cadwell Antimicrobial overproduction sustains intestinal inflammation by inhibiting Enterococcus colonization bioRxiv : the preprint server for biology, 2023-02-01;0(0):. 2023-02-01 [PMID: 36778381] (Mouse)
• A Ramadan, Z Cao, M Gadjeva, TS Zaidi, VA Rathinam, N Panjwani The NLRP3 Inflammasome Is Required for Protection Against Pseudomonas Keratitis Investigative Ophthalmology & Visual Science, 2023-02-01;64(2):11. 2023-02-01 [PMID: 36749596] (Mouse)
• P Jordan, A Costa, E Specker, O Popp, A Volkamer, R Piske, T Obrusnik, S Kleissle, K Stuke, A Rex, M Neuenschwa, JP von Kries, M Nazare, P Mertins, H Kettenmann, SA Wolf Small molecule inhibiting microglial nitric oxide release could become a potential treatment for neuroinflammation PLoS ONE, 2023-02-06;18(2):e0278325. 2023-02-06 [PMID: 36745631] (Mouse)
• Y Qiu, X Shen, O Ravid, D Atrakchi, D Rand, AE Wight, HJ Kim, S Liraz-Zalt, I Cooper, M Schnaider, H Cantor Definition of the contribution of an Osteopontin-producing CD11c+ microglial subset to Alzheimer&#039;s disease Proceedings of the National Academy of Sciences of the United States of America, 2023-02-02;120(6):e2218915120. 2023-02-02 [PMID: 36730200] (Mouse)
• L González-C, J P Green, I Cuadrado, Á Amesty, S Oramas-Roy, David Brou, A Estévez-Br, S Hortelano, B de Las Her Phenolic and quinone methide nor-triterpenes as selective NLRP3 inflammasome inhibitors Bioorganic chemistry, 2023-01-14;132(0):106362. 2023-01-14 [PMID: 36657273] (Mouse)
• JL Roncaioli, JP Babirye, RA Chavez, FL Liu, EA Turcotte, AY Lee, CF Lesser, RE Vance A hierarchy of cell death pathways confers layered resistance to shigellosis in mice Elife, 2023-01-16;12(0):. 2023-01-16 [PMID: 36645406] (Mouse)
• Y Lin, X Cui, Q Cao, R Bi, Y Liu, D Jing, C Yue, Q Zhao, Y Wang, S Liu, Y Su, K Formoso, S Susperregu, L Birnbaumer, M Freichel, Y Yang, L You, X Gao TRPC absence induces pro-inflammatory macrophages and gut microbe disorder, sensitizing mice to colitis International immunopharmacology, 2022-12-31;115(0):109655. 2022-12-31 [PMID: 36592529] (Mouse)
• DC Sarver, C Xu, LM Velez, S Aja, AE Jaffe, MM Seldin, RH Reeves, GW Wong Dysregulated systemic metabolism in a Down syndrome mouse model Molecular Metabolism, 2022-12-29;68(0):101666. 2022-12-29 [PMID: 36587842] (Mouse)
• G Lee, H Ahn, JH Yun, J Park, E Lee, S Oh, GS Lee JC2-11, a benzylideneacetophenone derivative, attenuates inflammasome activation Scientific Reports, 2022-12-28;12(1):22484. 2022-12-28 [PMID: 36577816] (Mouse)
• Z Zhang, R Venditti, L Ran, Z Liu, K Vivot, A Schürmann, JS Bonifacino, MA De Matteis, R Ricci Distinct changes in endosomal composition promote NLRP3 inflammasome activation Nature Immunology, 2022-11-28;0(0):. 2022-11-28 [PMID: 36443515] (Mouse)
• JS Baik, YN Seo, YC Lee, JM Yi, MH Rhee, MT Park, SD Kim Involvement of the p38 MAPK-NLRC4-Caspase-1 Pathway in Ionizing Radiation-Enhanced Macrophage IL-1beta Production International Journal of Molecular Sciences, 2022-11-09;23(22):. 2022-11-09 [PMID: 36430236] (Mouse)
• PF Kinoshita, AM Orellana, DZ Andreotti, GA de Souza, NP de Mello, L de Sá Lima, EM Kawamoto, C Scavone Consequences of the Lack of TNFR1 in Ouabain Response in the Hippocampus of C57BL/6J Mice Biomedicines, 2022-11-15;10(11):. 2022-11-15 [PMID: 36428505] (Mouse)
• C Oh, L Li, A Verma, AD Reuven, EA Miao, JB Bliska, Y Aachoui Neutrophil inflammasomes sense the subcellular delivery route of translocated bacterial effectors and toxins Cell Reports, 2022-11-22;41(8):111688. 2022-11-22 [PMID: 36417874] (Mouse, Transgenic Mouse)
• JS Park, SC Yang, HY Jeong, SY Lee, JG Ryu, JW Choi, HY Kang, SM Kim, SH Hwang, ML Cho, SH Park EC-18 prevents autoimmune arthritis by suppressing inflammatory cytokines and osteoclastogenesis Arthritis Research & Therapy, 2022-11-17;24(1):254. 2022-11-17 [PMID: 36397156] (Mouse)
• CS Rigazio, N Mariz-Pont, EP Caballero, FN Penas, NB Goren, MH Santamaría, RS Corral Involvement of glycoinositolphospholipid from Trypanosoma cruzi and macrophage migration inhibitory factor in proinflammatory mechanisms promoting cardiovascular injury mechanisms promoting cardiovascular inflammation tThe combined action of glycoinositolphospholipid from Trypanosoma cruzi and macrophage migration inhibitory factor increases proinflammatory mediator production by cardiomyocytes and vascular endothelial cells Microbial pathogenesis, 2022-11-12;0(0):105881. 2022-11-12 [PMID: 36379373] (Mouse)
• Z Pan, B Mao, Q Zhang, X Tang, B Yang, J Zhao, S Cui, H Zhang Postbiotics Prepared Using Lactobacillus paracasei CCFM1224 Prevent Nonalcoholic Fatty Liver Disease by Modulating the Gut Microbiota and Liver Metabolism International Journal of Molecular Sciences, 2022-11-04;23(21):. 2022-11-04 [PMID: 36362307] (Mouse)
• S Singh, IA Shaikh, SS More, MH Mahnashi, HM Almohaimee, M El-Sherbin, MM Ghoneim, A Umar, HK Soni, H Agrawal, BA Mannasaheb, AA Khan, UM Muddapur, SMS Iqubal Blockage of KHSRP-NLRP3 by MCC950 Can Reverse the Effect of Manganese-Induced Neuroinflammation in N2a Cells and Rat Brain International Journal of Molecular Sciences, 2022-10-30;23(21):. 2022-10-30 [PMID: 36362011] (Mouse, Rat)
• F Reusswig, A Polzin, M Klier, MA Dille, A Ayhan, M Benkhoff, C Lersch, A Prinz, S Gorressen, JW Fischer, M Kelm, M Elvers Only Acute but Not Chronic Thrombocytopenia Protects Mice against Left Ventricular Dysfunction after Acute Myocardial Infarction Cells, 2022-11-04;11(21):. 2022-11-04 [PMID: 36359896] (Mouse)
• MSJ Mangan, F Gorki, K Krause, A Heinz, A Pankow, T Ebert, D Jahn, K Hiller, V Hornung, M Maurer, FI Schmidt, R Gerhard, E Latz Transcriptional licensing is required for Pyrin inflammasome activation in human macrophages and bypassed by mutations causing familial Mediterranean fever PloS Biology, 2022-11-07;20(11):e3001351. 2022-11-07 [PMID: 36342970] (Human)
• Y Jiang, Y Yang, Y Hu, R Yang, J Huang, Y Liu, Y Wu, S Li, C Ma, F Humphries, B Wang, X Wang, Z Hu, S Yang Gasdermin D restricts anti-tumor immunity during PD-L1 checkpoint blockade Cell Reports, 2022-10-25;41(4):111553. 2022-10-25 [PMID: 36288704] (Mouse)
• S Li, Y Fang, Y Zhang, M Song, X Zhang, X Ding, H Yao, M Chen, Y Sun, J Ding, Q Wang, M Lu, G Wu, G Hu Microglial NLRP3 inflammasome activates neurotoxic astrocytes in depression-like mice Cell Reports, 2022-10-25;41(4):111532. 2022-10-25 [PMID: 36288697] (Mouse)
• AE Pottash, D Levy, A Jeyaram, L Kuo, SM Kronstadt, W Chao, SM Jay Combinatorial microRNA Loading into Extracellular Vesicles for Increased Anti-Inflammatory Efficacy Non-coding RNA, 2022-10-21;8(5):. 2022-10-21 [PMID: 36287123] (Mouse)
• J Liu, L Shi, W Huang, Z Zheng, X Huang, Y Su Homoharringtonine Attenuates Dextran Sulfate Sodium-Induced Colitis by Inhibiting NF-kappaB Signaling Mediators of Inflammation, 2022-09-29;2022(0):3441357. 2022-09-29 [PMID: 36211988] (Mouse)
• J Wang, Q Zhu, R Li, J Zhang, X Ye, X Li YAP1 protects against septic liver injury via ferroptosis resistance Cell & bioscience, 2022-10-01;12(1):163. 2022-10-01 [PMID: 36182901] (Mouse)
• JK Allen, TC Sutherland, AR Prater, CG Geoffroy, JP Pellois In vivo peptide-based delivery of a gene-modifying enzyme into cells of the central nervous system Science Advances, 2022-09-28;8(39):eabo2954. 2022-09-28 [PMID: 36170360] (Mouse)
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FAQs for IL-1 beta/IL-1F2 (DY401). (Showing 1 - 1 of 1 FAQs).

1. wondering what the difference is between your quantikine and duo set elisas?
   • Usually the duosets do not have the entire kit such as plates and buffers, whereas the other kits are complete.

Bioinformatics

• Gene Symbol: Il1b