Mouse IL-1 alpha/IL-1F1 Quantikine ELISA Kit

• Reactivity: Mu
• Applications: ELISA
• Conjugate: HRP

Mouse IL-1 alpha/IL-1F1 Quantikine ELISA Kit Summary

• Background: The Quantikine Mouse IL-1 alpha Immunoassay is a 4.5 hour solid phase ELISA designed to measure mouse IL-1 alpha levels in cell culture supernates and serum. It contains E. coli-expressed recombinant mouse IL-1 alpha and antibodies raised against the recombinant factor. This immunoassay has been shown to quantitate the recombinant mouse IL-1 alpha accurately. Results obtained using ...natural mouse IL-1 alpha showed dose response curves that were parallel to the standard curves obtained using the recombinant Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural mouse IL-1 alpha.
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• Specificity: Natural and recombinant mouse IL-1 alpha
• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Il1a

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: Interference observed with 1 or more available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 degreesC. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse IL-1 alpha/IL-1F1 Quantikine ELISA Kit

• BAF
• Hematopoietin-1
• IL1 alpha
• IL-1 alpha
• IL1
• IL1A
• IL-1A
• IL1-ALPHA
• IL1F1
• IL-1F1
• IL1F1hematopoietin-1
• interleukin 1, alpha
• interleukin-1 alpha
• LAF
• LEM
• preinterleukin 1 alpha
• pro-interleukin-1-alpha

Background

IL-1 alpha (Interleukin-1 alpha) is a cytokine that is induced during microbial exposure and promotes the release of multiple inflammatory mediators and acute phase proteins. It also supports hematopoietic stem cell expansion, promotes neutrophil mobilization from the bone marrow, and promotes osteoclast formation. IL-1 alpha signals through a receptor complex composed of IL-1 RI and IL-1 RAcP. It also binds the decoy receptor IL-1 RII which associates with IL-1 RAcP but does not transduce signaling.

⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for IL-1 alpha/IL-1F1 (MLA00)(33)

Publications using MLA00

• Ko, JS;Chang, BY;Choi, YJ;Choi, JS;Kwon, HY;Lee, JY;Kim, SY;Choung, SY; Ashwagandha Ethanol Extract Attenuates Sarcopenia-Related Muscle Atrophy in Aged Mice Nutrients 2024-01-03 [PMID: 38201986] (Mouse)
• Jiang, SY;Tian, T;Yao, H;Xia, XM;Wang, C;Cao, L;Hu, G;Du, RH;Lu, M; The cGAS-STING-YY1 axis accelerates progression of neurodegeneration in a mouse model of Parkinson's disease via LCN2-dependent astrocyte senescence Cell death and differentiation 2023-08-26 [PMID: 37633968] (Mouse)
• GK Vivian, RO da Silva, ACA Santos, AA Hastreiter, CC Dias, EN Makiyama, P Borelli, C de Oliveir, RA Fock The interaction between aging and protein malnutrition modulates peritoneal macrophage function: An experimental study in male mice Experimental gerontology, 2022-11-11;171(0):112025. 2022-11-11 [PMID: 36372284] (Mouse)
• M Kamiya, F Mizoguchi, K Kawahata, D Wang, M Nishibori, J Day, C Louis, IP Wicks, H Kohsaka, S Yasuda Targeting necroptosis in muscle fibers ameliorates inflammatory myopathies Nature Communications, 2022-01-10;13(1):166. 2022-01-10 [PMID: 35013338] (Mouse)
• P Innamarato, J Morse, A Mackay, S Asby, M Beatty, J Blauvelt, S Kidd, JE Mullinax, AA Sarnaik, S Pilon-Thom Intralesional injection of rose bengal augments the efficacy of gemcitabine chemotherapy against pancreatic tumors BMC Cancer, 2021-06-30;21(1):756. 2021-06-30 [PMID: 34187428] (Mouse)
• A Matsunami, M Mizuno-Kam, H Kawaki, E Takayama, K Ueno, M Ando, H Morimoto-I, Y Muramatsu, S Sumitomo, N Kondoh Augmented secretion of IL-1&alpha from mouse oral squamous cell carcinoma (OSCC) cells caused by serum deprivation and hypoxia promotes immune suppressive activity of mesenchymal stromal cells Journal of oral biosciences, 2021-06-18;0(0):. 2021-06-18 [PMID: 34153475] (Mouse)
• A Tripathi, C Whitehead, K Surrao, A Pillai, A Madeshiya, Y Li, H Khodadadi, AO Ahmed, G Turecki, B Baban, A Pillai Type 1 interferon mediates chronic stress-induced neuroinflammation and behavioral deficits via complement component 3-dependent pathway Molecular Psychiatry, 2021-04-08;0(0):. 2021-04-08 [PMID: 33833372] (Mouse)
• JJ Collier, HM Batdorf, TM Martin, KE Rohli, DH Burk, D Lu, CR Cooley, MD Karlstad, JW Jackson, TE Sparer, J Zhang, RL Mynatt, SJ Burke Pancreatic, but not myeloid-cell, expression of interleukin-1alpha is required for maintenance of insulin secretion and whole body glucose homeostasis Molecular Metabolism, 2020-12-05;44(0):101140. 2020-12-05 [PMID: 33285301] (Mouse)
• Z Li, J Wang, B Zheng, Z Guo Impact of combined ultrasound-microwave treatment on structural and functional properties of golden threadfin bream (Nemipterus virgatus) myofibrillar proteins and hydrolysates Ultrason Sonochem, 2020-03-09;65(0):105063. 2020-03-09 [PMID: 32199256] (Mouse)
• IJ Yeo, MJ Lee, A Baek, Z Miller, D Bhattarai, YM Baek, HJ Jeong, YK Kim, DE Kim, JT Hong, KB Kim A dual inhibitor of the proteasome catalytic subunits LMP2 and Y attenuates disease progression in mouse models of Alzheimer's disease Sci Rep, 2019-12-05;9(1):18393. 2019-12-05 [PMID: 31804556] (Mouse)
• N Guo, V DeAngelis, C Zhu, EH Schuchman, CM Simonaro Pentosan Polysulfate Treatment of Mucopolysaccharidosis Type IIIA Mice JIMD Rep, 2018-04-14;0(0):. 2018-04-14 [PMID: 29654542] (Mouse)
• G Hanouna, L Mesnard, S Vandermeer, J Perez, S Placier, JP Haymann, F Campagne, J Moroch, A Bataille, L Baud, E Letavernie Specific calpain inhibition protects kidney against inflammaging Sci Rep, 2017-08-14;7(1):8016. 2017-08-14 [PMID: 28808241] (Mouse)
• Kruppel-like factor 6 promotes macrophage-mediated inflammation by suppressing B cell leukemia/lymphoma 6 expression J Biol Chem, 2016-08-18;0(0):. 2016-08-18 [PMID: 27539853] (Mouse)
• Meng L, Jin W, Wang X RIP3-mediated necrotic cell death accelerates systematic inflammation and mortality. Proc Natl Acad Sci U S A, 2015-08-17;112(35):11007-12. 2015-08-17 [PMID: 26283397] (Mouse)
• Schonberger T, Jurgens T, Muller J, Armbruster N, Niermann C, Gorressen S, Sommer J, Tian H, di Paolo G, Scheller J, Fischer J, Gawaz M, Elvers M Pivotal role of phospholipase D1 in tumor necrosis factor-alpha-mediated inflammation and scar formation after myocardial ischemia and reperfusion in mice. Am J Pathol, 2014-07-18;184(9):2450-64. 2014-07-18 [PMID: 25046692] (Mouse)
• de Oliveira D, Hastreiter A, Mello A, de Oliveira Beltran J, Oliveira Santos E, Borelli P, Fock R The effects of protein malnutrition on the TNF-RI and NF-kappaB expression via the TNF-alpha signaling pathway. Cytokine, 2014-07-06;69(2):218-25. 2014-07-06 [PMID: 25005154] (Mouse)
• Thongchote K, Svasti S, Teerapornpuntakit J, Krishnamra N, Charoenphandhu N Running exercise alleviates trabecular bone loss and osteopenia in hemizygous beta-globin knockout thalassemic mice. Am J Physiol Endocrinol Metab, 2014-04-29;306(12):E1406-17. 2014-04-29 [PMID: 24780610] (Mouse)
• Vital P, Castro P, Tsang S, Ittmann M The senescence-associated secretory phenotype promotes benign prostatic hyperplasia. Am J Pathol, 2014-01-13;184(3):721-31. 2014-01-13 [PMID: 24434012] (Mouse)
• Drexler , Stefan K, Bonsignore , Luca, Masin , Mark, Tardivel , Aubry, Jackstadt , Rene, Hermeking , Heiko, Schneider , Pascal, Gross , Olaf, Tschopp , Jurg, Yazdi , Amir S Tissue-specific opposing functions of the inflammasome adaptor ASC in the regulation of epithelial skin carcinogenesis. Proc Natl Acad Sci U S A, 2012-10-22;109(45):18384-9. 2012-10-22 [PMID: 23090995] (Mouse)
• Elevating body temperature enhances hematopoiesis and neutrophil recovery after total body irradiation in an IL-1-, IL-17-, and G-CSF-dependent manner. Blood, 2012-07-17;120(13):2600-9. 2012-07-17 [PMID: 22806894] (Mouse)
• Luheshi NM, Giles JA, Lopez-Castejon G, Brough D Sphingosine regulates the NLRP3-inflammasome and IL-1beta release from macrophages. Eur. J. Immunol., 2011-12-27;42(3):716-25. 2011-12-27 [PMID: 22105559] (Mouse)
• Pauwels NS, Bracke KR, Dupont LL, Van Pottelberge GR, Provoost S, Vanden Berghe T, Vandenabeele P, Lambrecht BN, Joos GF, Brusselle GG Role of IL-1alpha and the Nlrp3/caspase-1/IL-1beta axis in cigarette smoke-induced pulmonary inflammation and COPD. Eur. Respir. J., 2011-05-26;38(5):1019-28. 2011-05-26 [PMID: 21622588] (Mouse)
• Wang H, Cheng F Histone Deacetylase Inhibitor LAQ824 Augments Inflammatory Responses in Macrophages through Transcriptional Regulation of IL-10. J. Immunol., 2011-03-02;186(0):3986. 2011-03-02 [PMID: 21368229] (Mouse)
• Masters SL, Dunne A, Subramanian SL, Hull RL, Tannahill GM, Sharp FA, Becker C, Franchi L, Yoshihara E, Chen Z, Mullooly N, Mielke LA, Harris J, Coll RC, Mills KH, Mok KH, Newsholme P, Nunez G, Yodoi J, Kahn SE, Lavelle EC, O'Neill LA Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1beta in type 2 diabetes. Nat. Immunol., 2010-09-12;11(10):897-904. 2010-09-12 [PMID: 20835230] (Mouse)
• Alm AS, Li K, Yang D, Andersson R, Lu Y, Wang X Varying susceptibility of pulmonary cytokine production to lipopolysaccharide in mice. Cytokine, 2009-12-29;49(3):256-63. 2009-12-29 [PMID: 20042347] (Mouse)
• Surguladze D, Deevi D, Claros N, Corcoran E, Wang S, Plym MJ, Wu Y, Doody J, Mauro DJ, Witte L, Busam KJ, Pytowski B, Rodeck U, Tonra JR Tumor necrosis factor-alpha and interleukin-1 antagonists alleviate inflammatory skin changes associated with epidermal growth factor receptor antibody therapy in mice. Cancer Res., 2009-07-07;69(14):5643-7. 2009-07-07 [PMID: 19584274] (Mouse)
• Zhang X, Gao L, Lei L, Zhong Y, Dube P, Berton MT, Arulanandam B, Zhang J, Zhong G A MyD88-dependent early IL-17 production protects mice against airway infection with the obligate intracellular pathogen Chlamydia muridarum. J. Immunol., 2009-06-19;183(2):1291-300. 2009-06-19 [PMID: 19542374] (Mouse)
• Bitko V, Musiyenko A, Barik S Viral infection of the lungs through the eye. J. Virol., 2006-10-18;81(2):783-90. 2006-10-18 [PMID: 17050596] (Mouse)
• Ishida Y, Kondo T, Kimura A, Matsushima K, Mukaida N Absence of IL-1 receptor antagonist impaired wound healing along with aberrant NF-kappaB activation and a reciprocal suppression of TGF-beta signal pathway. J. Immunol., 2006-05-01;176(9):5598-606. 2006-05-01 [PMID: 16622029] (Mouse)
• Wei S, Kitaura H, Zhou P, Ross FP, Teitelbaum SL IL-1 mediates TNF-induced osteoclastogenesis. J. Clin. Invest., 2005-02-01;115(2):282-90. 2005-02-01 [PMID: 15668736] (Mouse)
• Megid J, Kaneno R, Nozaki CN, Brito CJ, Almeida MF Increased interleukin-10 associated with low IL-6 concentration correlated with greater survival rates in mice infected by rabies virus vaccinated against it and immunomodulated with P. acnes. Comp. Immunol. Microbiol. Infect. Dis., 2004-11-01;27(6):393-411. 2004-11-01 [PMID: 15325513] (Mouse)
• Hao Z, Hampel B, Yagita H, Rajewsky K T cell-specific ablation of Fas leads to Fas ligand-mediated lymphocyte depletion and inflammatory pulmonary fibrosis. J. Exp. Med., 2004-05-17;199(10):1355-65. 2004-05-17 [PMID: 15148335] (Mouse)
• Hanisch UK, Prinz M, Angstwurm K, Hausler KG, Kann O, Kettenmann H, Weber JR The protein tyrosine kinase inhibitor AG126 prevents the massive microglial cytokine induction by pneumococcal cell walls. Eur. J. Immunol., 2001-07-01;31(7):2104-15. 2001-07-01 [PMID: 11449364] (Mouse)

FAQs for IL-1 alpha/IL-1F1 (MLA00). (Showing 1 - 1 of 1 FAQs).

1. wondering what the difference is between your quantikine and duo set elisas?
   • Usually the duosets do not have the entire kit such as plates and buffers, whereas the other kits are complete.

Bioinformatics

• Gene Symbol: Il1a