Mouse IFN-beta ELISA Kit

• Reactivity: Mu
• Applications: ELISA
• Conjugate: Biotin

Mouse IFN-beta ELISA Kit Summary

• Specificity: Mouse IFN-beta
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Ifnb1

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse IFN-beta ELISA Kit

• Fibroblast interferon
• IFB
• IFBIFNB
• IFF
• IFNB
• IFNB1
• IFNbeta
• IFN-beta
• interferon beta
• interferon, beta 1, fibroblast
• MGC96956

Background

Interferon-beta (IFN-beta) is a cytokine that is produced by fibroblasts and pathogen-exposed dendritic cells, macrophages, and endothelial cells. It signals through the heterodimeric IFN-alpha/beta Receptor. IFN-beta-deficient mice show increased susceptibility to experimental autoimmune encephalomyelitis (EAE), a disease model of human multiple sclerosis (MS). Furthermore, IFN-beta has been shown to suppress the Th17 cell response in both MS and EAE and has commonly been used as a treatment for MS.

Publications for IFN-beta (42400-1)(27)

Publications using 42400-1

• G Wan, Y An, J Tao, Y Wang, Q Zhou, R Yang, Q Liang MicroRNA-129-5p alleviates spinal cord injury in mice via suppressing the apoptosis and inflammatory response through HMGB1/TLR4/NF-&kappaB pathway Biosci. Rep., 2020;40(3):. 2020 [PMID: 32096822] (Mouse)
• JH Kim, JE Yoon, C Nikapitiya, TH Kim, MB Uddin, HC Lee, YH Kim, JH Hwang, K Chathurang, WAG Chathurang, HS Choi, CJ Kim, JU Jung, CH Lee, JS Lee Small Heterodimer Partner Controls the Virus-Mediated Antiviral Immune Response by Targeting CREB-Binding Protein in the Nucleus Cell Rep, 2019;27(7):2105-2118.e5. 2019 [PMID: 31091449] (Mouse)
• K Wang, H Ma, H Liu, W Ye, Z Li, L Cheng, L Zhang, Y Lei, L Shen, F Zhang The Glycoprotein and Nucleocapsid Protein of Hantaviruses Manipulate Autophagy Flux to Restrain Host Innate Immune Responses Cell Rep, 2019;27(7):2075-2091.e5. 2019 [PMID: 31091447] (Human)
• P Xia, S Wang, B Ye, Y Du, C Li, Z Xiong, Y Qu, Z Fan A Circular RNA Protects Dormant Hematopoietic Stem Cells from DNA Sensor cGAS-Mediated Exhaustion Immunity, 2018;0(0):. 2018 [PMID: 29625897] (Mouse)
• CH Jin, HC Park, Y So, B Nam, SN Han, JB Kim Comparison of the Anti-Inflammatory Activities of Supercritical Carbon Dioxide versus Ethanol Extracts from Leaves of Perilla frutescens Britt. Radiation Mutant Molecules, 2017;22(2):. 2017 [PMID: 28218690] (Mouse)
• The ubiquitin E3 ligase TRIM31 promotes aggregation and activation of the signaling adaptor MAVS through Lys63-linked polyubiquitination Nat. Immunol, 2016;0(0):. 2016 [PMID: 27992402] (Mouse)
• Rosmarinic Acid Methyl Ester Inhibits LPS-Induced NO Production via Suppression of MyD88- Dependent and -Independent Pathways and Induction of HO-1 in RAW 264.7 Cells Molecules, 2016;21(8):. 2016 [PMID: 27548124] (Mouse)
• IFN-? Production During the dsRNA Response in Hepatocytes Involves Coordinated and Feed Forward Signaling Through TLR3, PKR, iNOS and Src J Biol Chem, 2016;0(0):. 2016 [PMID: 27226571] (Mouse)
• Liu L, Nishikawa T, Kaneda Y An RNA Molecule Derived From Sendai Virus DI Particles Induces Antitumor Immunity and Cancer Cell-selective Apoptosis. Mol Ther, 2016;24(1):135-45. 2016 [PMID: 26548591] (Mouse)
• Zhu W, Zhao S, Liu Z, Cheng L, Wang Q, Yan K, Chen Q, Wu H, Han D Pattern recognition receptor-initiated innate antiviral responses in mouse epididymal epithelial cells. J Immunol, 2015;194(10):4825-35. 2015 [PMID: 25840915] (Mouse)
• Park , Sun Hong, Baek , Seung-Il, Yun , Jieun, Lee , Seungmin, Yoon , Da Young, Jung , Jae-Kyun, Jung , Sang-Hun, Hwang , Bang Yeo, Hong , Jin Tae, Han , Sang-Bae, Kim , Youngsoo IRAK4 as a molecular target in the amelioration of innate immunity-related endotoxic shock and acute liver injury by chlorogenic acid. J Immunol, 2015;194(3):1122-30. 2015 [PMID: 25548221] (Mouse)
• Ranjan P, Singh N, Kumar A, Neerincx A, Kremmer E, Cao W, Davis W, Katz J, Gangappa S, Lin R, Kufer T, Sambhara S NLRC5 interacts with RIG-I to induce a robust antiviral response against influenza virus infection. Eur J Immunol, 2015;45(3):758-72. 2015 [PMID: 25404059] (Mouse)
• Zaru R, Edgar A, Hanauer A, Watts C Structural and functional basis for p38-MK2-activated Rsk signaling in toll-like receptor-stimulated dendritic cells. Mol Cell Biol, 2015;35(1):132-40. 2015 [PMID: 25332232] (Mouse)
• Desch , A Nicole, Gibbings , Sophie L, Clambey , Eric T, Janssen , William, Slansky , Jill E, Kedl , Ross M, Henson , Peter M, Jakubzick , Claudia Dendritic cell subsets require cis-activation for cytotoxic CD8 T-cell induction. Nat Commun, 2014;5(0):4674. 2014 [PMID: 25135627] (Mouse)
• Kanagavelu S, Flores C, Termini J, Riveron R, Romero L, Chung K, Ruiz J, Hyun J, Yuan X, Dagvadorj J, Fukata M TIR-domain-containing adapter-inducing interferon-beta (TRIF) regulates Th17-mediated intestinal immunopathology in colitis. Mucosal Immunol, 2015;8(2):296-306. 2015 [PMID: 25073675] (Mouse)
• Dulek D, Newcomb D, Toki S, Goliniewska K, Cephus J, Reiss S, Bates J, Crowe J, Boyd K, Moore M, Zhou W, Peebles R STAT4 deficiency fails to induce lung Th2 or Th17 immunity following primary or secondary respiratory syncytial virus (RSV) challenge but enhances the lung RSV-specific CD8+ T cell immune response to secondary challenge. J Virol, 2014;88(17):9655-72. 2014 [PMID: 24920804] (Mouse)
• Bosmann M, Strobl B, Kichler N, Rigler D, Grailer J, Pache F, Murray P, Muller M, Ward P Tyrosine kinase 2 promotes sepsis-associated lethality by facilitating production of interleukin-27. J Leukoc Biol, 2014;96(1):123-31. 2014 [PMID: 24604832] (Mouse)
• Cai , Xinming, Xu , Yongyao, Kim , You-Me, Loureiro , Joseph, Huang , Qian PIKfyve, a class III lipid kinase, is required for TLR-induced type I IFN production via modulation of ATF3. J Immunol, 2014;192(7):3383-9. 2014 [PMID: 24600036] (Mouse)
• Zhang W, Zhou Q, Xu W, Cai Y, Yin Z, Gao X, Xiong S DNA-dependent activator of interferon-regulatory factors (DAI) promotes lupus nephritis by activating the calcium pathway. J Biol Chem, 2013;288(19):13534-50. 2013 [PMID: 23553627] (Mouse)
• Ferguson , Brian J, Mansur , Daniel S, Peters , Nicholas, Ren , Hongwei, Smith , Geoffrey DNA-PK is a DNA sensor for IRF-3-dependent innate immunity. Elife, 2013;1(0):e00047. 2013 [PMID: 23251783] (Mouse)
• Chen K, Chang C, Huang C, Lin C, Lin W, Lo Y, Yang C, Hsing E, Chen L, Shih S, Shiau A, Lei H, Tan T, Ling P TBK1-associated protein in endolysosomes (TAPE)/CC2D1A is a key regulator linking RIG-I-like receptors to antiviral immunity. J Biol Chem, 2012;287(38):32216-21. 2012 [PMID: 22833682] (Mouse)
• Leu SW, Shi L, Xu C, Zhao Y, Liu B, Li Y, Shiedlin A, Xiang C, Shen H, Quinn DA, Hales CA, Zhao H TLR4 through IFN-beta promotes low molecular mass hyaluronan-induced neutrophil apoptosis. J. Immunol., 2011;186(1):556-62. 2011 [PMID: 21098223] (Mouse)
• Guerra S, Gonzalez JM, Climent N, Reyburn H, Lopez-Fernandez LA, Najera JL, Gomez CE, Garcia F, Gatell JM, Gallart T, Esteban M Selective induction of host genes by MVA-B, a candidate vaccine against HIV/AIDS. J. Virol., 2010;84(16):8141-52. 2010 [PMID: 20534857] (Mouse)
• Watanabe T, Asano N, Fichtner-Feigl S, Gorelick PL, Tsuji Y, Matsumoto Y, Chiba T, Fuss IJ, Kitani A, Strober W NOD1 contributes to mouse host defense against Helicobacter pylori via induction of type I IFN and activation of the ISGF3 signaling pathway. J. Clin. Invest., 2010;120(5):1645-62. 2010 [PMID: 20389019] (Mouse)
• Zurney J, Howard KE, Sherry B Basal expression levels of IFNAR and Jak-STAT components are determinants of cell-type-specific differences in cardiac antiviral responses. J. Virol., 2007;81(24):13668-80. 2007 [PMID: 17942530] (Mouse)
• Zetterstrom CK, Jiang W, Wahamaa H, Ostberg T, Aveberger AC, Schierbeck H, Lotze MT, Andersson U, Pisetsky DS, Erlandsson Harris H Pivotal advance: inhibition of HMGB1 nuclear translocation as a mechanism for the anti-rheumatic effects of gold sodium thiomalate. J. Leukoc. Biol., 2007;83(1):31-8. 2007 [PMID: 17913975] (Mouse)
• Qin L, Greenland JR, Moriya C Effects of type I interferons on the adjuvant properties of plasmid granulocyte-macrophage colony-stimulating factor in vivo. J. Virol., 2007;81(19):10606-13. 2007 [PMID: 17652387] (Mouse)

Bioinformatics

• Gene Symbol: Ifnb1