Mouse IFN-beta ELISA Kit

• Reactivity: Mu
• Applications: ELISA
• Conjugate: Biotin

Mouse IFN-beta ELISA Kit Summary

• Specificity: Mouse IFN-beta
• Source: N/A
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Ifnb1

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse IFN-beta ELISA Kit

• Fibroblast interferon
• IFB
• IFBIFNB
• IFF
• IFNB
• IFNB1
• IFNbeta
• IFN-beta
• interferon beta
• interferon, beta 1, fibroblast
• MGC96956

Background

Interferon-beta (IFN-beta) is a cytokine that is produced by fibroblasts and pathogen-exposed dendritic cells, macrophages, and endothelial cells. It signals through the heterodimeric IFN-alpha/beta Receptor. IFN-beta-deficient mice show increased susceptibility to experimental autoimmune encephalomyelitis (EAE), a disease model of human multiple sclerosis (MS). Furthermore, IFN-beta has been shown to suppress the Th17 cell response in both MS and EAE and has commonly been used as a treatment for MS.

Publications for IFN-beta (42400-1)(31)

Publications using 42400-1

• F Raya Tonet, P Clua, K Fukuyama, G Marcial, J Sacur, G Marranzino, M Tomokiyo, G Vizoso-Pin, A Garcia-Can, S Kurata, H Kitazawa, J Villena The Ability of Postimmunobiotics from L. rhamnosus CRL1505 to Protect against Respiratory Syncytial Virus and Pneumococcal Super-Infection Is a Strain-Dependent Characteristic Microorganisms, 2022-11-03;10(11):. 2022-11-03 [PMID: 36363777] (Mouse)
• G Wan, Y An, J Tao, Y Wang, Q Zhou, R Yang, Q Liang MicroRNA-129-5p alleviates spinal cord injury in mice via suppressing the apoptosis and inflammatory response through HMGB1/TLR4/NF-&kappaB pathway Biosci. Rep., 2020-03-27;40(3):. 2020-03-27 [PMID: 32096822] (Mouse)
• JH Kim, JE Yoon, C Nikapitiya, TH Kim, MB Uddin, HC Lee, YH Kim, JH Hwang, K Chathurang, WAG Chathurang, HS Choi, CJ Kim, JU Jung, CH Lee, JS Lee Small Heterodimer Partner Controls the Virus-Mediated Antiviral Immune Response by Targeting CREB-Binding Protein in the Nucleus Cell Rep, 2019-05-14;27(7):2105-2118.e5. 2019-05-14 [PMID: 31091449] (Mouse)
• K Wang, H Ma, H Liu, W Ye, Z Li, L Cheng, L Zhang, Y Lei, L Shen, F Zhang The Glycoprotein and Nucleocapsid Protein of Hantaviruses Manipulate Autophagy Flux to Restrain Host Innate Immune Responses Cell Rep, 2019-05-14;27(7):2075-2091.e5. 2019-05-14 [PMID: 31091447] (Human, Mouse)
• Sujin An, Yung Jin Jeon, Ara Jo, Hyun Jung Lim, Young Eun Han, Sung Woo Cho et al. Initial Influenza Virus Replication Can Be Limited in Allergic Asthma Through Rapid Induction of Type III Interferons in Respiratory Epithelium Frontiers in Immunology 2018-05-17 [PMID: 29867963] (Mouse)
• P Xia, S Wang, B Ye, Y Du, C Li, Z Xiong, Y Qu, Z Fan A Circular RNA Protects Dormant Hematopoietic Stem Cells from DNA Sensor cGAS-Mediated Exhaustion Immunity, 2018-04-03;0(0):. 2018-04-03 [PMID: 29625897] (Mouse)
• CH Jin, HC Park, Y So, B Nam, SN Han, JB Kim Comparison of the Anti-Inflammatory Activities of Supercritical Carbon Dioxide versus Ethanol Extracts from Leaves of Perilla frutescens Britt. Radiation Mutant Molecules, 2017-02-17;22(2):. 2017-02-17 [PMID: 28218690] (Mouse)
• The ubiquitin E3 ligase TRIM31 promotes aggregation and activation of the signaling adaptor MAVS through Lys63-linked polyubiquitination Nat. Immunol, 2016-12-19;0(0):. 2016-12-19 [PMID: 27992402] (Mouse)
• Rosmarinic Acid Methyl Ester Inhibits LPS-Induced NO Production via Suppression of MyD88- Dependent and -Independent Pathways and Induction of HO-1 in RAW 264.7 Cells Molecules, 2016-08-18;21(8):. 2016-08-18 [PMID: 27548124] (Mouse)
• IFN-? Production During the dsRNA Response in Hepatocytes Involves Coordinated and Feed Forward Signaling Through TLR3, PKR, iNOS and Src J Biol Chem, 2016-05-17;0(0):. 2016-05-17 [PMID: 27226571] (Mouse)
• Liu L, Nishikawa T, Kaneda Y An RNA Molecule Derived From Sendai Virus DI Particles Induces Antitumor Immunity and Cancer Cell-selective Apoptosis. Mol Ther, 2015-11-09;24(1):135-45. 2015-11-09 [PMID: 26548591] (Mouse)
• Zhu W, Zhao S, Liu Z, Cheng L, Wang Q, Yan K, Chen Q, Wu H, Han D Pattern recognition receptor-initiated innate antiviral responses in mouse epididymal epithelial cells. J Immunol, 2015-04-03;194(10):4825-35. 2015-04-03 [PMID: 25840915] (Mouse)
• Wang P, Zhao W, Zhao K, Zhang L, Gao C TRIM26 negatively regulates interferon-beta production and antiviral response through polyubiquitination and degradation of nuclear IRF3. PLoS Pathog, 2015-03-12;11(3):e1004726. 2015-03-12 [PMID: 25763818] (Mouse)
• Park , Sun Hong, Baek , Seung-Il, Yun , Jieun, Lee , Seungmin, Yoon , Da Young, Jung , Jae-Kyun, Jung , Sang-Hun, Hwang , Bang Yeo, Hong , Jin Tae, Han , Sang-Bae, Kim , Youngsoo IRAK4 as a molecular target in the amelioration of innate immunity-related endotoxic shock and acute liver injury by chlorogenic acid. J Immunol, 2014-12-29;194(3):1122-30. 2014-12-29 [PMID: 25548221] (Mouse)
• Ranjan P, Singh N, Kumar A, Neerincx A, Kremmer E, Cao W, Davis W, Katz J, Gangappa S, Lin R, Kufer T, Sambhara S NLRC5 interacts with RIG-I to induce a robust antiviral response against influenza virus infection. Eur J Immunol, 2014-12-23;45(3):758-72. 2014-12-23 [PMID: 25404059] (Mouse)
• Zaru R, Edgar A, Hanauer A, Watts C Structural and functional basis for p38-MK2-activated Rsk signaling in toll-like receptor-stimulated dendritic cells. Mol Cell Biol, 2014-10-20;35(1):132-40. 2014-10-20 [PMID: 25332232] (Mouse)
• Desch , A Nicole, Gibbings , Sophie L, Clambey , Eric T, Janssen , William, Slansky , Jill E, Kedl , Ross M, Henson , Peter M, Jakubzick , Claudia Dendritic cell subsets require cis-activation for cytotoxic CD8 T-cell induction. Nat Commun, 2014-08-19;5(0):4674. 2014-08-19 [PMID: 25135627] (Mouse)
• Kanagavelu S, Flores C, Termini J, Riveron R, Romero L, Chung K, Ruiz J, Hyun J, Yuan X, Dagvadorj J, Fukata M TIR-domain-containing adapter-inducing interferon-beta (TRIF) regulates Th17-mediated intestinal immunopathology in colitis. Mucosal Immunol, 2014-07-30;8(2):296-306. 2014-07-30 [PMID: 25073675] (Mouse)
• Dulek D, Newcomb D, Toki S, Goliniewska K, Cephus J, Reiss S, Bates J, Crowe J, Boyd K, Moore M, Zhou W, Peebles R STAT4 deficiency fails to induce lung Th2 or Th17 immunity following primary or secondary respiratory syncytial virus (RSV) challenge but enhances the lung RSV-specific CD8+ T cell immune response to secondary challenge. J Virol, 2014-06-11;88(17):9655-72. 2014-06-11 [PMID: 24920804] (Mouse)
• Bosmann M, Strobl B, Kichler N, Rigler D, Grailer J, Pache F, Murray P, Muller M, Ward P Tyrosine kinase 2 promotes sepsis-associated lethality by facilitating production of interleukin-27. J Leukoc Biol, 2014-03-06;96(1):123-31. 2014-03-06 [PMID: 24604832] (Mouse)
• Cai , Xinming, Xu , Yongyao, Kim , You-Me, Loureiro , Joseph, Huang , Qian PIKfyve, a class III lipid kinase, is required for TLR-induced type I IFN production via modulation of ATF3. J Immunol, 2014-03-05;192(7):3383-9. 2014-03-05 [PMID: 24600036] (Mouse)
• Jayaraman A, Jackson D, Message S, Pearson R, Aniscenko J, Caramori G, Mallia P, Papi A, Shamji B, Edwards M, Westwick J, Hansel T, Stanciu L, Johnston S, Bartlett N IL-15 complexes induce NK- and T-cell responses independent of type I IFN signaling during rhinovirus infection. Mucosal Immunol, 2014-01-29;7(5):1151-64. 2014-01-29 [PMID: 24472849] (Mouse)
• Zhang W, Zhou Q, Xu W, Cai Y, Yin Z, Gao X, Xiong S DNA-dependent activator of interferon-regulatory factors (DAI) promotes lupus nephritis by activating the calcium pathway. J Biol Chem, 2013-04-03;288(19):13534-50. 2013-04-03 [PMID: 23553627] (Mouse)
• Ferguson , Brian J, Mansur , Daniel S, Peters , Nicholas, Ren , Hongwei, Smith , Geoffrey DNA-PK is a DNA sensor for IRF-3-dependent innate immunity. Elife, 2012-12-18;1(0):e00047. 2012-12-18 [PMID: 23251783] (Mouse)
• Chen K, Chang C, Huang C, Lin C, Lin W, Lo Y, Yang C, Hsing E, Chen L, Shih S, Shiau A, Lei H, Tan T, Ling P TBK1-associated protein in endolysosomes (TAPE)/CC2D1A is a key regulator linking RIG-I-like receptors to antiviral immunity. J Biol Chem, 2012-07-25;287(38):32216-21. 2012-07-25 [PMID: 22833682] (Mouse)
• Leu SW, Shi L, Xu C, Zhao Y, Liu B, Li Y, Shiedlin A, Xiang C, Shen H, Quinn DA, Hales CA, Zhao H TLR4 through IFN-beta promotes low molecular mass hyaluronan-induced neutrophil apoptosis. J. Immunol., 2010-11-22;186(1):556-62. 2010-11-22 [PMID: 21098223] (Mouse)
• Guerra S, Gonzalez JM, Climent N, Reyburn H, Lopez-Fernandez LA, Najera JL, Gomez CE, Garcia F, Gatell JM, Gallart T, Esteban M Selective induction of host genes by MVA-B, a candidate vaccine against HIV/AIDS. J. Virol., 2010-06-09;84(16):8141-52. 2010-06-09 [PMID: 20534857] (Mouse)
• Watanabe T, Asano N, Fichtner-Feigl S, Gorelick PL, Tsuji Y, Matsumoto Y, Chiba T, Fuss IJ, Kitani A, Strober W NOD1 contributes to mouse host defense against Helicobacter pylori via induction of type I IFN and activation of the ISGF3 signaling pathway. J. Clin. Invest., 2010-04-12;120(5):1645-62. 2010-04-12 [PMID: 20389019] (Mouse)
• Zurney J, Howard KE, Sherry B Basal expression levels of IFNAR and Jak-STAT components are determinants of cell-type-specific differences in cardiac antiviral responses. J. Virol., 2007-10-17;81(24):13668-80. 2007-10-17 [PMID: 17942530] (Mouse)
• Zetterstrom CK, Jiang W, Wahamaa H, Ostberg T, Aveberger AC, Schierbeck H, Lotze MT, Andersson U, Pisetsky DS, Erlandsson Harris H Pivotal advance: inhibition of HMGB1 nuclear translocation as a mechanism for the anti-rheumatic effects of gold sodium thiomalate. J. Leukoc. Biol., 2007-10-03;83(1):31-8. 2007-10-03 [PMID: 17913975] (Mouse)
• Qin L, Greenland JR, Moriya C Effects of type I interferons on the adjuvant properties of plasmid granulocyte-macrophage colony-stimulating factor in vivo. J. Virol., 2007-07-25;81(19):10606-13. 2007-07-25 [PMID: 17652387] (Mouse)

FAQs for IFN-beta (42400-1). (Showing 1 - 1 of 1 FAQs).

1. What is the difference between the Quantikine and Duoset ELISA kits?
   • Our Quantikine kits are fully optimized and validated for the sample types listed on the product specific webpage and datasheet, as this can vary between kits. Each kit is supplied ready to use with one pre-coated 96-well plate, a detection antibody directly conjugated to HRP, and all other necessary reagents. These kits are ideal for researchers who want the convenience of a ready to use and optimized ELISA product. Some of these kits are also available prepackaged in larger 6 and 50 plate sizes.Our DuoSet Kits, in contrast, are ELISA development kits containing the capture and detection antibody, the mass-value calibrated standard, and streptavidin-HRP to prepare approximately 5 or 15 plates. Ancillary reagents will need to be used/purchased, and for most kits, we will recommend one of our Ancillary Reagent Kits, which contain the reagents we use ourselves in-house. DuoSet kits are validated only for cell culture supernatant samples and therefore require further development and validation for accurate measurement in more complex samples such as serum and plasma. Our DuoSet Kits offer an economical, flexible alternative for the experienced ELISA user.

Bioinformatics

• Gene Symbol: Ifnb1