MKK4/MEK4 Antibody (323042) [Alexa Fluor® 647]

• Reactivity: Hu
• Applications: ICC/IF
• Clone: 323042
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 647

MKK4/MEK4 Antibody (323042) [Alexa Fluor® 647] Summary

• Immunogen: E. coli-derived recombinant human MKK4
  Met1-Asp399
  Accession # P45985
• Specificity: Detects human MKK4 in direct ELISAs. This antibody does not cross-react with recombinant human MKK7.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for MKK4/MEK4 Antibody (323042) [Alexa Fluor® 647]

• c-Jun N-terminal kinase kinase 1
• dual specificity mitogen-activated protein kinase kinase 4
• JNK activating kinase 1
• JNK-activated kinase 1
• JNK-activating kinase 1
• JNKK
• JNKK1
• JNKK1MAPK/ERK kinase 4
• MAP kinase kinase 4
• MAP2K4
• MAPKK4
• MEK4
• MEK4MEK 4
• mitogen-activated protein kinase kinase 4
• MKK4
• MKK4SAPK/ERK kinase 1
• PRKMK4
• PRKMK4MAPKK 4
• SEK1
• SERK1
• SERK1EC 2.7.12.2

Background

Mitogen-activated protein kinase kinase 4 (MKK4 or MAP2K4), also known as SAPK/ERK kinase 1 (SEK1) and Jun kinase kinase 1 (JNKK1), is activated by proinflammatory cytokines and environmental stresses. Activation occurs through phosphorylation at Ser257 and Thr261 by several upstream MAPK kinase kinases (MAP3Ks). MKK4 is a dual specificity protein kinase, phosphorylating and activating the JNK family of MAP kinases at Thr and Tyr positions within the phosphoacceptor sequence Thr-Pro-Tyr.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.