MKK4/MEK4 Products

Antibodies
MKK4/MEK4 Antibody (8A8)
MKK4/MEK4 Antibody (8A8)
Species: Hu, Ca
Applications: WB, Flow, ICC/IF, IHC, IHC-P, IP
Host: Mouse Monoclonal
MKK4/MEK4 [p Tyr261] Antibody ...
MKK4/MEK4 [p Tyr261] Antibody
AF2990
Species: Hu, Mu, Rt
Applications: WB, ICC
Host: Rabbit Polyclonal
MKK4/MEK4 Antibody (5H4)
MKK4/MEK4 Antibody (5H4)
NBP2-37275
Species: Hu
Applications: WB, ELISA, Flow, IHC
Host: Mouse Monoclonal
Lysates
MKK4/MEK4 Overexpression Lysa ...
MKK4/MEK4 Overexpression Lysate (N...
NBL1-12850
Applications: WB
MKK4/MEK4 Overexpression Lysa ...
MKK4/MEK4 Overexpression Lysate (D...
H00006416-T01
Species: Hu
Applications: WB
Proteins
Recombinant Human MKK4/MEK4 P ...
Recombinant Human MKK4/MEK4 Protein
H00006416-P01
Species: Hu
Applications: WB, ELISA, PA
Recombinant Human MKK4/MEK4 P ...
Recombinant Human MKK4/MEK4 Protein
H00006416-Q01
Species: Hu
Applications: WB, ELISA, PA
RNAi
MKK4/MEK4 RNAi
MKK4/MEK4 RNAi
H00006416-R02
Species: Hu
Applications: RNAi, RNAi SP

Description

MKK4, also known as JNKK1 and SEK1, is a dual specificity kinase that belongs to the Ser/Thr protein kinase family. MKK4 is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. MKK4 phosphorylates and activates p38 MAP kinase and JNK but not ERK 1/2 (1-2). JNK is activated by dual phosphorylation at Thr and Tyr by MKK4 and MKK7; although MKK4 will preferentially phosphorylate Tyr (3). MKK4 is also known to be a tumor suppressor, as mutations inactivating the MKK4 gene have been found in 5% of a wide variety of tumor types (4).

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Product By Gene ID 6416
Alternate Names
  • JNK-activated kinase 1
  • JNK-activating kinase 1
  • JNK activating kinase 1
  • c-Jun N-terminal kinase kinase 1
  • dual specificity mitogen-activated protein kinase kinase 4
  • SEK1
  • MAPKK4
  • JNKK
  • SERK1EC 2.7.12.2
  • MKK4SAPK/ERK kinase 1
  • MEK4MEK 4
  • PRKMK4MAPKK 4
  • JNKK1MAPK/ERK kinase 4
  • MAP kinase kinase 4
  • mitogen-activated protein kinase kinase 4

Research Areas for MKK4/MEK4

Find related products by research area and learn more about each of the different research areas below.

Angiogenesis
Cancer
MAP Kinase Signaling
Phospho-Specific
Protein Kinase
Signal Transduction
Tyrosine Kinases

Bioinformatics Tool for MKK4/MEK4

Discover related pathways, diseases and genes to MKK4/MEK4. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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