MICL/CLEC12A Antibody [Biotin]

• Reactivity: Hu
• Applications: WB
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Biotin
• Concentration: LYOPH

MICL/CLEC12A Antibody [Biotin] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human MICL/CLEC12A isoform alpha
  Thr67-Ala265
  Accession # NP_612210
• Specificity: Detects human MICL/CLEC12A in Western blots. In Western blots, approximately 10% cross-reactivity with recombinant mouse MICL is observed.
• Source: N/A
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: CLEC12A
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Western Blot 0.1 ug/mL
• Readout System:
  • Streptavidin Native Protein NBP2-29367
  • Streptavidin Native Protein NBP2-29370
  • Streptavidin Native Protein NBP2-29371

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
• Preservative: No Preservative
• Concentration: LYOPH
• Reconstitution Instructions: Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for MICL/CLEC12A Antibody [Biotin]

• CD371
• CLEC12A
• CLL1
• CLL-1
• C-type lectin domain family 12, member A
• DCAL-2
• MICL

Background

MICL, also known as C-type lectin-like molecule-1 (CLL-1), Killer cell lectin-like receptor KLRL1 and C type lectin domain family 12, member A (CLEC12A), is a type II transmembrane highly glycosylated protein that contains a functional tyrosine-based inhibitory motif in its cytoplasmic tail. The gene for MICL has been mapped to the natural killer gene complex (NKC) on human chromosome 12p13.2. MICL contains a non-classic C-type domain that binds non-sugar ligands. It is primarily expressed on NK cells, T cells, dendritic cells, monocytes and macrophages. By alternative splicing, multiple splice isoforms exist. MICL is a negative regulator of granulocytes and monocyte function and inhibits NK cell cytotoxicity. The amino acid sequence of human MICL extracellular domain is 53%, 65% and 55% identical to that of mouse, canine and bovine MICL, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CLEC12A
• Uniprot:
  • NP_612210()