mGluR2 Antibody (455311) [Alexa Fluor® 405]

• Reactivity: Hu
• Applications: IHC
• Clone: 455311
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 405

mGluR2 Antibody (455311) [Alexa Fluor® 405] Summary

• Immunogen: Mouse myeloma cell line, NS0-derived human mGluR2
  Glu19-Ser498
  Accession # Q14416
• Specificity: Detects human mGluR2 in direct ELISAs.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 degreesC as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for mGluR2 Antibody (455311) [Alexa Fluor® 405]

• GLUR2
• glutamate metabotropic receptor 2
• glutamate receptor, metabotropic 2
• GPRC1B
• GPRC1Bmetabotropic glutamate receptor 2
• GRM2
• mGlu2
• mGluR2
• MGLUR2glutamate receptor homolog
• mGluR7

Background

Metabotropic glutamate receptor 2 (mGluR2, also known as GPRC1B and GRM2) is an 872 aa, predicted 96 kDa multipass G protein coupled inhibitory receptor (GPCR) belonging to group II of the metabotropic glutamate receptor family. The receptor functions as an autoreceptor for glutamate, that upon activation, inhibits the emptying of vesicular contents at the presynaptic terminal of glutamatergic neurons. It is localized largely on the presynaptic side of glutamatergic and other neurotransmitter synapses in areas of the forebrain. mGluR2 activity is potentially involved in some anxiety disorders. The long N-terminal extracellular region of human mGluR2 (aa 1-498) shares 97% aa identity with either mouse or rat mGluR2.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Uniprot:
  • Q14416()