mGluR2/3 Antibody

Images

 
Western Blot: metabotropic Glutamate Receptor 2/3 Antibody [NB300-124] - Western blot of 10 ug of rat hippocampal lysate showing the specific immunolabeling of the ~110k monomer and the ~220k dimer of mGluR2 and mGluR3.
Western Blot: metabotropic Glutamate Receptor 2/3 Antibody [NB300-124] - Western blot of 10 ug of HEK 293 cells expression. As shown in the autoradiograph, the mGluR2/3 antibody recognizes both the ~110k monomer and the ...read more
Western Blot: metabotropic Glutamate Receptor 2/3 Antibody [NB300-124] - Specificity of mGluR2/3 (NB 300-124) in rat tissue lysate.

Product Details

Summary
Reactivity Mu, Rt, Hu, Bv, Ca, Pm, ZeSpecies Glossary
Applications WB, ICC/IF, IHC, IHC-Fr
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

mGluR2/3 Antibody Summary

Immunogen
Peptide from the C-terminal region of rat mGluR2 and rat mGluR3.
Localization
Integral membrane protein
Specificity
Specific for the ~110k monomer and the ~220k dimer of mGluR2 and mGluR3. Immunolabeling is blocked by preadsorption of antibody with the peptide used as antigen to generate the antibody.
Predicted Species
Human (100%), Bovine (100%), Primate (100%), Canine (100%), Zebrafish (100%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
GRM2
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:1000
  • Immunocytochemistry/Immunofluorescence 1:10-1:500
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:500
Application Notes
Use in Immunocytochemistry/immunofluorescence reported in scientific literature (PMID 17099896)
Publications
Read Publication using
NB300-124 in the following applications:

Reactivity Notes

Mouse reactivity reported in scientific literature (PMID: 17099896).

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
10mM HEPES (pH 7.5), 0.15M NaCl, 0.1 mg/ml BSA and 50% Glycerol
Preservative
0.1% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for mGluR2/3 Antibody

  • GLUR2
  • glutamate metabotropic receptor 2
  • glutamate receptor, metabotropic 2
  • GPRC1Bmetabotropic glutamate receptor 2
  • mGlu2
  • mGluR2
  • mGluR2/3
  • MGLUR2glutamate receptor homolog

Background

Glutamate is the main excitatory neurotransmitter in the brain. For many years it had been considered to act only on the ligand-gated receptor channels-termed NMDA, AMPA and kainate receptors that are involved in the fast excitatory synaptic transmission. Recently, glutamate has been shown to regulate enzymes producing second messengers via specific receptors coupled to G-proteins. These receptors are called metabotropic glutamate receptors. In expression systems, Group-I receptors, stimulate phospholipase C as revealed by an increase in phosphoinositide turnover, and Ca2+ release from internal stores. Group-II and -III receptors are coupled to the inhibition of adenylyl cyclase. The Group-I receptors include mGluR1a and mGluR5. The Group-II receptors in include mGluR2 and mGluR3.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for mGluR2/3 Antibody (NB300-124)(1)

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: ICC/IF.


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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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mGluR2/3 NB300-124

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Bioinformatics

Gene Symbol GRM2
Entrez
Uniprot