mGluR2/3 Products

Description

The mGluR proteins (metabotropic glutamate receptors) are members of the G-protein-coupled receptor family and are functionally and pharmacologically distinct from the GluR proteins (ionotropic glutamate receptors). The eight currently known mGluR proteins are mediated by two G proteins with opposing regulation of adenylate cyclase pathways. The activities of mGluR-1 and mGluR-5 are mediated by a G protein that activates a phosphatidylinositolcalcium second messenger system and generates a calcium-activated chloride current. The remainder of the eight subtypes of mGluR have an activity mediated by a G protein that inhibits adenylate cyclase activity. mGluR-2, which may interact with GRASP, acts as a receptor for glutamate. It may also be involved in the regulation of neurotransmission suppression and in synaptogenesis or synaptic stablization. mGluR-3,which may interact with GRASP, acts as a receptor for glutamate.

Bioinformatics

Entrez	2912 Human 24415 Rat
Product By Gene ID	2912
Alternate Names	GLUR2 glutamate metabotropic receptor 2 glutamate receptor, metabotropic 2 GPRC1Bmetabotropic glutamate receptor 2 mGlu2 mGluR2 mGluR2/3 MGLUR2glutamate receptor homolog

Research Areas for mGluR2/3

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Neuronal Cell Markers
Neuroscience
Neurotransmission
Tumor Suppressors
Vision