MGC20410 Antibody (PCRP-BATF2-2B9) [Janelia Fluor® 549]

• Reactivity: Hu
• Applications: ELISA, Flow, IHC, IP
• Clone: PCRP-BATF2-2B9
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Janelia Fluor 549

MGC20410 Antibody (PCRP-BATF2-2B9) [Janelia Fluor® 549] Summary

• Immunogen: Recombinant fragment (around aa5-140) of human MGC20410 (exact sequence is proprietary)
• Localization: Nucleus.
• Specificity: This antibody recognizes a transcription factor involved in differentiation of CD8+ thymic dendritic cells MGC20410 has been implicated in breast cancer, malignant glioma and metastatis melanoma progression
• Isotype: IgG2b Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: BATF2
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Flow Cytometry
  • Immunohistochemistry-Paraffin
  • Immunoprecipitation
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for MGC20410 Antibody (PCRP-BATF2-2B9) [Janelia Fluor® 549]

• basic leucine zipper transcription factor, ATF-like 2
• basic leucine zipper transcriptional factor ATF-like 2
• B-ATF-2
• MGC20410
• SARI
• suppressor of AP-1 regulated by IFN

Background

BATF2 (Basic leucine zipper transcriptional factor ATF-like 2) is a 274 amino acid member of the AP-1 transcription factor family. It controls the differentiation of lineage-specific cells in the immune system. It participates in differentiating CD8+ thymic conventional dendritic cells and acts by forming a heterodimer with JUN family proteins. They then recognize and bind the DNA sequence 5'-TGA(CG)TCA-3'. It acts as a tumor suppressor by interfering with AP-1 regulated activation of CYR61/CCN1 transcription and its downstream signaling. CYR61/CCN1 signaling induces anchorage-independent growth and invasion in several cancer types, such as breast cancer, malignant glioma and metastatic melanoma.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: BATF2