MGC20410 Antibody (PCRP-BATF2-2B9) [Alexa Fluor® 405]

• Reactivity: Hu
• Applications: ELISA, Flow, IHC, IP
• Clone: PCRP-BATF2-2B9
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 405

MGC20410 Antibody (PCRP-BATF2-2B9) [Alexa Fluor® 405] Summary

• Immunogen: Recombinant fragment (around aa5-140) of human MGC20410 (exact sequence is proprietary)
• Localization: Nucleus.
• Specificity: This antibody recognizes a transcription factor involved in differentiation of CD8+ thymic dendritic cells MGC20410 has been implicated in breast cancer, malignant glioma and metastatis melanoma progression
• Isotype: IgG2b Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: BATF2
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Flow Cytometry
  • Immunohistochemistry-Paraffin
  • Immunoprecipitation
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified

Notes

Alexa Fluor (R) products are provided under an intellectual property license from Life Technologies Corporation. The purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: (i) in manufacturing; (ii) to provide a service, information, or data in return for payment; (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5791 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@lifetech.com. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for MGC20410 Antibody (PCRP-BATF2-2B9) [Alexa Fluor® 405]

• basic leucine zipper transcription factor, ATF-like 2
• basic leucine zipper transcriptional factor ATF-like 2
• B-ATF-2
• MGC20410
• SARI
• suppressor of AP-1 regulated by IFN

Background

BATF2 (Basic leucine zipper transcriptional factor ATF-like 2) is a 274 amino acid member of the AP-1 transcription factor family. It controls the differentiation of lineage-specific cells in the immune system. It participates in differentiating CD8+ thymic conventional dendritic cells and acts by forming a heterodimer with JUN family proteins. They then recognize and bind the DNA sequence 5'-TGA(CG)TCA-3'. It acts as a tumor suppressor by interfering with AP-1 regulated activation of CYR61/CCN1 transcription and its downstream signaling. CYR61/CCN1 signaling induces anchorage-independent growth and invasion in several cancer types, such as breast cancer, malignant glioma and metastatic melanoma.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: BATF2