Mesothelin Antibody (K1)

Product Discontinued

Mesothelin Antibody (K1) Summary

• Immunogen: Spleen lymphocytes from mice fused with OVCAR-3, an ovarian tumorcell line derived from poorly differentiated adenocarcinoma of the ovary.
• Localization: Cell Membrane
• Specificity: This recognizes CAK 1, a 40 kD cell surface glycoprotein, selectively expressed by malignant mesotheliomas as well as by non-mucinous ovarian carcinomas and squamous tumors of the esophagus and cervix.
• Isotype: IgG1 Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: MSLN
• Purity: Unpurified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:40
  • Immunohistochemistry-Frozen 1:40
• Application Notes: Immunohistochemistry- frozen. Optimal dilutions and concentrations should be determined by the end user.

Reactivity Notes

Cross-reacts with Human and Cynomolgus Monkey.

Packaging, Storage & Formulations

• Storage: Store at 4C. Do not freeze.
• Buffer: Ascites in PBS and BSA
• Preservative: 0.1% Sodium Azide
• Purity: Unpurified

Alternate Names for Mesothelin Antibody (K1)

• CAK1 antigen
• CAK1
• megakaryocyte potentiating factor
• Mesothelin
• MPF
• MPFSMRP
• MSLN
• Pre-pro-megakaryocyte-potentiating factor
• SMR
• soluble MPF mesothelin related protein

Background

Mesothelin is a GPI-linked cell-surface glycoprotein, that is present on the surface of normal mesothelium and is overexpressed in many patients with epithelial ovarian cancer and malignant mesotheliomas.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: MSLN
• Entrez:
  • 10232(Human)