MeCP2 Antibody (1B11)

Images

 
Western Blot: MeCP2 Antibody (1B11) [H00004204-M03] - Analysis of MECP2 expression in Hela S3 NE (Cat # L013V3).
Immunohistochemistry-Paraffin: MeCP2 Antibody (1B11) [H00004204-M03] - Analysis of monoclonal antibody to MECP2 on formalin-fixed paraffin-embedded human cerebral cortex. Antibody concentration 3 ug/ml
Western Blot: MeCP2 Antibody (1B11) [H00004204-M03] - Analysis of MECP2 expression in Jurkat (Cat # L017V1).
Sandwich ELISA: MeCP2 Antibody (1B11) [H00004204-M03] - Detection limit for recombinant GST tagged MECP2 is approximately 0.1ng/ml as a capture antibody.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, ELISA, IHC-P
Clone
1B11
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Order Details

MeCP2 Antibody (1B11) Summary

Immunogen
MECP2 (AAH11612, 81 a.a. - 170 a.a.) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. PKQRRSIIRDRGPMYDDPTLPEGWTRKLKQRKSGRSAGKYDVYLINPQGKAFRSKVELIAYFEKVGDTSLDPNDFDFTVTGRGSPSRREQ
Marker
Nucleus Marker
Specificity
MECP2 (1B11)
Isotype
IgG2a Kappa
Clonality
Monoclonal
Host
Mouse
Gene
MECP2
Purity
IgG purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot
  • ELISA
  • Immunohistochemistry-Paraffin
Application Notes
Antibody reactivity against cell lysate and recombinant protein for WB. It has also been used for IHC-P and ELISA.
Positive Control
Brain Cerebellum Lysate (NB820-59365)

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.4)
Preservative
No Preservative
Purity
IgG purified

Notes

Quality control test: Antibody Reactive Against Recombinant Protein.

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for MeCP2 Antibody (1B11)

  • AUTSX3
  • DKFZp686A24160
  • MeCp-2 protein
  • mental retardation, X-linked 79
  • methyl CpG binding protein 2 (Rett syndrome)
  • X-linked 16

Background

DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of some cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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WB Video Protocol

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Positive Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

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Bioinformatics Tool for MeCP2 Antibody (H00004204-M03)

Discover related pathways, diseases and genes to MeCP2 Antibody (H00004204-M03). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Blogs on MeCP2.

New MECP2 Study Suggests Important Link to GABA
MECP2 antibodies are used in DNA methylation studies as well as research into Rett syndrome, a progressive neurological disorder caused by a mutation in the MECP2 gene. Now, a new study has been published by the laboratory where the Rett Syndrome gene...  Read full blog post.

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Bioinformatics

Gene Symbol MECP2
Entrez
OMIM
Uniprot