Maxi Potassium channel beta Antibody

Western Blot: Maxi Potassium channel beta Antibody [NBP1-33484] - Sample (30 ug of whole cell lysate) A: A431 B: H1299 12% SDS PAGE; antibody diluted at 1:1000.

Western Blot: Maxi Potassium channel beta Antibody [NBP1-33484] - Sample (50 ug of whole cell lysate) A: mouse heart 12% SDS PAGE; antibody diluted at 1:10000.

• Reactivity: Hu, Mu, RM
• Applications: WB
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated

Maxi Potassium channel beta Antibody Summary

• Immunogen: Recombinant protein encompassing a sequence within the center region of human Maxi Potassium channel beta. The exact sequence is proprietary.
• Localization: Membrane, Multi-pass membrane protein
• Predicted Species: Rhesus Macaque (94%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: KCNMB1
• Purity: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Western Blot 1:1000-1:10000
• Theoretical MW: 22 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Rat reactivity reported in scientific literature (PMID: 27165430). Dog (84%), Rabbit (85%), Bovine (84%).

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: PBS, 1% BSA, 20% Glycerol
• Preservative: 0.01% Thimerosal
• Purity: Antigen Affinity-purified

Alternate Names for Maxi Potassium channel beta Antibody

• BK channel beta subunit
• BK channel subunit beta-1
• BKbeta
• BKbeta1
• Calcium-activated potassium channel subunit beta
• calcium-activated potassium channel subunit beta-1
• Calcium-activated potassium channel, subfamily M subunit beta-1
• Charybdotoxin receptor subunit beta-1
• Hbeta1
• hslo-beta
• K(VCA)beta
• K(VCA)beta-1
• KCNMB1
• large conductance Ca2+-activated K+ channel beta 1 subunit
• Maxi K channel beta subunit
• Maxi K channel subunit beta-1
• Maxi Potassium channel beta
• potassium large conductance calcium-activated channel, subfamily M, beta member1
• Slo-beta
• Slo-beta-1

Background

Potassium channels are a group of ubiquitously expressed proteins that serve numerous functions in excitable and non-excitable cells. One class of integral membrane potassium channels is the large conductance, calcium-activated potassium channel (Maxi K+). Maxi K+ differs from most other potassium channels in that its activation is controlled by both increases in intracellular calcium and by membrane depolarization. Maxi K+ dual activation is possible because of its structure. The core of the channel, which is similar to other potassium channels, is a Maxi K+ alpha homotetramer that contains both a voltage sensor and an intracellular calcium binding domain. In vascular smooth muscle, an auxiliary beta-subunit is found in a 1:1 stoichiometry. The beta-subunit exhibits its effect on the Maxi K+ channel by effectively decreasing by 5- to 10- fold the concentration of calcium required to keep the pore open. Maxi K+ beta is the target for possible therapeutics because of its role in blood flow and blood pressure regulation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause reproductive toxicity with developmental effects.  For more information go to www.P65Warnings.ca.gov.

Publications for Maxi Potassium channel beta Antibody (NBP1-33484)(2)

Publications using NBP1-33484

• Petho Z, Tanner MR, Tajhya RB. Different expression of beta subunits of the kCa1. 1 channel by invasive and non-invasive human fibroblast-like synoviocytes. Arthritis Res Ther. 2016-05-10 [PMID: 27165430] (WB, Rat, Human)
• Petho ZD. The functional role of Ca2+-and voltage-gated potassium channels in activated human T cells and fibroblast-like synoviocytes. Thesis 2017-01-01 (WB, Human)

Bioinformatics

• Gene Symbol: KCNMB1