Maxi Potassium channel beta Antibody

Images

 
Western Blot: Maxi Potassium channel beta Antibody [NBP1-33484] - Sample (30 ug of whole cell lysate) A: A431 B: H1299 12% SDS PAGE; antibody diluted at 1:1000.
Western Blot: Maxi Potassium channel beta Antibody [NBP1-33484] - Sample (50 ug of whole cell lysate) A: mouse heart 12% SDS PAGE; antibody diluted at 1:10000.

Product Details

Summary
Reactivity Hu, Mu, Rt, RMSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml

Order Details

Maxi Potassium channel beta Antibody Summary

Immunogen
Recombinant protein encompassing a sequence within the center region of human KCNMB1. The exact sequence is proprietary.
Localization
Membrane, Multi-pass membrane protein
Predicted Species
Rhesus Macaque (94%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
KCNMB1
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:1000-1:10000
Theoretical MW
22 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Publications
Read Publication using
NBP1-33484 in the following applications:

  • WB
    1 publication

Reactivity Notes

Rat reactivity reported in scientific literature (PMID: 27165430). Dog (84%), Rabbit (85%), Bovine (84%).

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.0), 1.0% BSA and 20% Glycerol
Preservative
0.01% Thimerosal
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Maxi Potassium channel beta Antibody

  • BK channel beta subunit
  • BK channel subunit beta-1
  • BKbeta
  • BKbeta1
  • Calcium-activated potassium channel subunit beta
  • calcium-activated potassium channel subunit beta-1
  • Calcium-activated potassium channel, subfamily M subunit beta-1
  • Charybdotoxin receptor subunit beta-1
  • hbeta1
  • hslo-beta
  • K(VCA)beta
  • k(VCA)beta-1
  • large conductance Ca2+-activated K+ channel beta 1 subunit
  • Maxi K channel beta subunit
  • Maxi K channel subunit beta-1
  • potassium large conductance calcium-activated channel, subfamily M, beta member1
  • Slo-beta
  • slo-beta-1

Background

Potassium channels are a group of ubiquitously expressed proteins that serve numerous functions in excitable and non-excitable cells. One class of integral membrane potassium channels is the large conductance, calcium-activated potassium channel (Maxi K+). Maxi K+ differs from most other potassium channels in that its activation is controlled by both increases in intracellular calcium and by membrane depolarization. Maxi K+ dual activation is possible because of its structure. The core of the channel, which is similar to other potassium channels, is a Maxi K+ alpha homotetramer that contains both a voltage sensor and an intracellular calcium binding domain. In vascular smooth muscle, an auxiliary beta-subunit is found in a 1:1 stoichiometry. The beta-subunit exhibits its effect on the Maxi K+ channel by effectively decreasing by 5- to 10- fold the concentration of calcium required to keep the pore open. Maxi K+ beta is the target for possible therapeutics because of its role in blood flow and blood pressure regulation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Maxi Potassium channel beta Antibody (NBP1-33484)(1)

We have publications tested in 2 confirmed species: Human, Rat.

We have publications tested in 1 application: WB.


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Bioinformatics

Gene Symbol KCNMB1