Maxi Potassium channel beta Products

Description

Potassium channels are a group of ubiquitously expressed proteins that serve numerous functions in excitable and non-excitable cells. One class of integral membrane potassium channels is the large conductance, calcium-activated potassium channel (Maxi K+). Maxi K+ differs from most other potassium channels in that its activation is controlled by both increases in intracellular calcium and by membrane depolarization. Maxi K+ dual activation is possible because of its structure. The core of the channel, which is similar to other potassium channels, is a Maxi K+ alpha homotetramer that contains both a voltage sensor and an intracellular calcium binding domain. In vascular smooth muscle, an auxiliary beta-subunit is found in a 1:1 stoichiometry. The beta-subunit exhibits its effect on the Maxi K+ channel by effectively decreasing by 5- to 10- fold the concentration of calcium required to keep the pore open. Maxi K+ beta is the target for possible therapeutics because of its role in blood flow and blood pressure regulation.

Bioinformatics

Entrez	16533 Mouse 29747 Rat 3779 Human
Uniprot	AAH25707 Human Q16558 Human
Product By Gene ID	3779
Alternate Names	BK channel beta subunit BK channel subunit beta-1 BKbeta BKbeta1 Calcium-activated potassium channel subunit beta calcium-activated potassium channel subunit beta-1 Calcium-activated potassium channel, subfamily M subunit beta-1 Charybdotoxin receptor subunit beta-1 hbeta1 Hbeta1 hslo-beta K(VCA)beta K(VCA)beta-1 k(VCA)beta-1 large conductance Ca2+-activated K+ channel beta 1 subunit Maxi K channel beta subunit Maxi K channel subunit beta-1 potassium large conductance calcium-activated channel, subfamily M, beta member1 SLO-BETA Slo-beta slo-beta-1 Slo-beta-1

Research Areas for Maxi Potassium channel beta

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Potassium Channels