MAD1L1/MAD1 Antibody [Alexa Fluor® 350]

• Reactivity: Hu
• Applications: WB
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Alexa Fluor 350

MAD1L1/MAD1 Antibody [Alexa Fluor® 350] Summary

• Immunogen: E. coli-derived recombinant human MAD1L1
  Met1-Asp350
  Accession # Q9Y6D9
• Specificity: Detects human MAD1L1 in Western blots.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for MAD1L1/MAD1 Antibody [Alexa Fluor® 350]

• hMAD1
• HsMAD1
• MAD1 mitotic arrest deficient-like 1 (yeast)
• MAD1
• MAD1L1
• MAD1-like protein 1
• MAD1yeast, homolog-like 1
• Mitotic checkpoint MAD1 protein homolog
• PIG9
• Tax-binding protein 181
• TP53I9
• tumor protein p53 inducible protein 9
• TXBP181
• TXBP181MAD1 (mitotic arrest deficient, yeast, homolog)-like 1

Background

MAD1L1 (mitotic arrest deficient 1-like 1) is a member of the spindle-assembly checkpoint (SAC) which prevents anaphase from occurring until all chromosomes are properly aligned at the metaphase plate. Upon checkpoint activation, MAD1L1 recruits MAD2 to unattached kinetochores, promoting the binding of MAD2 to CDC20, the activator for the anaphase-promoting complex. MAD1L1 has been implicated to have tumor-suppressing functions, but in small-cell lung cancer cell lines, the MAD1L1 gene is the most frequent copy number gain, suggesting a more complex role.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.