LPAR2/LPA2/EDG-4 Antibody [Alexa Fluor® 350]

• Reactivity: Hu
• Host: Sheep
• Conjugate: Alexa Fluor 350

LPAR2/LPA2/EDG-4 Antibody [Alexa Fluor® 350] Summary

• Specificity: Detects human LPAR2 in direct ELISAs and Western blots. In direct ELISAs, less than 1% cross-reactivity with recombinant human LPAR1 is observed.
• Isotype: IgG
• Host: Sheep

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for LPAR2/LPA2/EDG-4 Antibody [Alexa Fluor® 350]

• EDG4
• EDG-4
• EDG4FLJ93869
• endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor4,LPA receptor EDG4
• G protein-coupled receptor
• LPA2
• LPA-2
• LPA2LPA receptor 2
• LPAR2
• lysophosphatidic acid receptor 2
• lysophosphatidic acid receptor EDG4
• Lysophosphatidic acid receptor Edg-4

Background

LPAR2 (Lysophosphatidic acid receptor 2; also LPA₂ and EDG4) is a 39 kDa member of the GPCR1 family of proteins.  It has limited expression, and is found on mammalian macrophages, fibroblasts and cardiac myocytes.  LPAR2 binds to, and is activated by LPA, a molecule principally derived from activated platelets.  Although LPAR2 appears to prefer myristoyl and palmitoyl LPA, multiple forms of LPA are recognized by the receptor.  LPAR2 reportedly mediates chemotaxis, arachidonic acid release, and cell rounding.  Human LPAR2 is a 351 amino acid (aa) 7–transmembrane (TM) protein (SwissProt # Q9HBW0).  It contains a 33 aa extracellular N-terminus (aa #1-33), seven TM segments (aa #34-297) and a 54 aa C-terminal cytoplasmic tail.  There is one splice variant that is associated with tumor cells, and which originally was given the designation EDG4 (endothelium differentiation gene 4).  This shows a 35 aa substitution for aa #348-351.  Over aa #1-33, 91-103, 168-188 and 264-279 collectively, human LPAR2 shares 75% aa identity with mouse LPAR2.  

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.