LIR-6/LILRA1 Antibody (356316) [Unconjugated]

• Reactivity: Hu
• Applications: WB
• Clone: 356316
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated
• Concentration: LYOPH

LIR-6/LILRA1 Antibody (356316) [Unconjugated] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human LILRA1/CD85i/LIR-6
  Pro17-Asn461
  Accession # O75019
• Specificity: Detects human LILRA1/CD85i/LIR-6 in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant human (rh) ILT2, rhILT4, rhILT5, rhLIR-4, rhLIR-5, or rhLIR-8 is observed.
• Source: N/A
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: LILRA1
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Western Blot 1 ug/mL

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
• Preservative: No Preservative
• Concentration: LYOPH
• Reconstitution Instructions: Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for LIR-6/LILRA1 Antibody (356316) [Unconjugated]

• CD85 antigen-like family member I
• CD85i antigen
• CD85i
• leukocyte immunoglobulin-like receptor subfamily A member 1 soluble isoform
• leukocyte immunoglobulin-like receptor subfamily A member 1
• leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1
• LILRA1
• LIR6
• LIR-6
• LIR-6Leukocyte immunoglobulin-like receptor 6
• LIR6MGC126563

Background

Leukocyte Immunoglobulin-like Receptor 6 (LIR-6), also called LILRA1 or CD85i, is a glycoprotein member of the LIR family of leukocyte Ig-like receptors. As an activating LIR, LIR-6 has a short cytoplasmic tail and a charged aa within the TM domain which interacts with FcR gamma . Both four (LIR-6a) and two (LIR-6b) Ig-like domain forms are expressed by monocytes and B cells. Human LIR-6 has no non-primate ortholog, but shows up to 80% aa identity with human ILT-1c and KIR-p91/PIR-B. A mouse homolog, gp49B2, has structural similarity but limited sequence identity.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: LILRA1
• Uniprot:
  • O75019()