Legumain/Asparaginyl Endopeptidase Antibody (46I3) [Allophycocyanin]

• Reactivity: Hu
• Applications: WB, ELISA
• Clone: 46I3
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Allophycocyanin

Legumain/Asparaginyl Endopeptidase Antibody (46I3) [Allophycocyanin] Summary

• Immunogen: Human recombinant Legumain/Asparaginyl Endopeptidase
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: LGMN
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: PBS
• Preservative: 0.05% Sodium Azide
• Purity: Protein G purified

Alternate Names for Legumain/Asparaginyl Endopeptidase Antibody (46I3) [Allophycocyanin]

• AEP
• Asparaginyl Endopeptidase
• cysteine protease 1
• Legumain
• LGMN
• LGMN1
• Protease, cysteine 1
• protease, cysteine, 1 (legumain)
• PRSC1EC 3.4.22.34

Background

Legumain encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: LGMN