Latrophilin 2/LPHN2 Antibody

Images

 
Immunohistochemistry-Paraffin: Latrophilin 2/LPHN2 Antibody [NLS1133] - Analysis of anti-LPHN2 antibody with human ovary, graafian follicle.
Immunohistochemistry-Paraffin: Latrophilin 2/LPHN2 Antibody [NLS1133] - Analysis of anti-LPHN2 antibody with ovary.

Product Details

Summary
Reactivity Hu, Mu, Rt, Po, Bt, Bv, Ca, Eq, Mk, Rb, Ch, Fi, Op, Pm, XpSpecies Glossary
Applications IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1.0 mg/ml

Order Details

Latrophilin 2/LPHN2 Antibody Summary

Immunogen
Synthetic 16 amino acid peptide from N-terminal extracellular domain of human LPHN2.
Localization
Integral membrane protein.
Specificity
Human LPHN2. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Predicted Species
Primate (94%), Xenopus (94%), Chicken (94%), Opossum (100%), Fish (94%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
LPHN2
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry-Paraffin 7 ug/ml

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (100%), Gibbon (100%), Elephant (100%), Panda (100%), Platypus (100%), Marmoset (94%), Pufferfish (94%).

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.1% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Latrophilin 2/LPHN2 Antibody

  • Calcium-independent alpha-latrotoxin receptor 2
  • CIRL2
  • CIRL-2
  • CL2
  • KIAA0786
  • Latrophilin 2
  • Latrophilin homolog 1
  • latrophilin homolog 2 (cow)
  • latrophilin-2
  • LEC1LPHH1latrophilin 1
  • lectomedin-1
  • LPHN2

Background

LPHN2 is an Orphan-B Receptor that binds alpha-latrotoxin, a potent presynaptic neurotoxin present in the venom of the black widow spider, in a Ca2+-independent manner. As with the other two latrophilins, it shares homology with lectin, olfactomedin, and transmembrane domains, and possesses variable C-termini and various alternative-splice sites. LPHN2 is endoproteolytically cleaved at the end of the GPS domain, and the two subunits remain non-covantely linked as a heterodimer. LPHN2 has been reported to be expressed in brain, breast, placenta, kidney, spleen, ovary, heart, and lung. ESTs have been isolated from a wide variety of tissue libraries.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Diseases for Latrophilin 2/LPHN2 Antibody (NLS1133)

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Bioinformatics

Gene Symbol LPHN2
Entrez