KLRG1 Antibody (697213) [Alexa Fluor® 488]

• Reactivity: Hu
• Applications: WB
• Clone: 697213
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 488

KLRG1 Antibody (697213) [Alexa Fluor® 488] Summary

• Immunogen: Chinese hamster ovary cell line CHO-derived recombinant human KLRG1
  Leu60-Phe195
  Accession # Q96E93
• Specificity: Detects human KLRG1 in direct ELISAs and Western blots.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for KLRG1 Antibody (697213) [Alexa Fluor® 488]

• 2F1
• CLEC15A
• CLEC15AMAFA-LIKE
• C-type lectin domain family 15 member A
• C-type lectin domain family 15, member A
• ITIM-containing receptor MAFA-L
• killer cell lectin-like receptor subfamily G member 1
• killer cell lectin-like receptor subfamily G, member 1
• KLRG1
• MAFA
• MAFAL
• MAFA-L
• MAFA-like receptor
• MAFAMAFA-2F1
• mast cell function-associated antigen (ITIM-containing)
• Mast cell function-associated antigen
• MGC13600

Background

KLRG1 (killer cell lectin-like receptor G1), also known as MAFA (mast cell function associated), is a 30-38 kDa type II transmembrane inhibitory glycoprotein of the C‑type lectin family, designated CLEC15A. KLRG1 cDNA encodes 195 amino acids (aa) including an intracellular ITIM motif and a 136 aa extracellular domain (ECD) with a single C-type lectin domain. The human KLRG1 ECD shares 57% and 54% aa identity with mouse and rat KLRG1, respectively. A 189 aa isoform diverges at aa 186. KLRG1 binds E-, N- and R-cadherins and functions as an MHC-independent means of identifying non-self pathogens and epithelial tumor cells with low E-cadherin expression. It is expressed as a monomer or disulfide-linked homodimer on NK and T cell subsets such as tumor-infiltrating lymphocytes.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.