Kirrel2/NEPH3 Antibody (318311) [Unconjugated]

• Reactivity: Hu, Mu
• Applications: WB
• Clone: 318311
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated
• Concentration: LYOPH

Kirrel2/NEPH3 Antibody (318311) [Unconjugated] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human Kirrel2
  Gly21-Arg503
  Accession # Q6UWL6
• Specificity: Detects human and mouse Kirrel2/NEPH3 in direct ELISAs and Western blots.
• Source: N/A
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: KIRREL2
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Western Blot 1 ug/mL

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
• Preservative: No Preservative
• Concentration: LYOPH
• Reconstitution Instructions: Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Kirrel2/NEPH3 Antibody (318311) [Unconjugated]

• DKFZp564A1164
• Filtrin
• FILTRINkin of IRRE-like protein 2
• kin of IRRE like 2 (Drosophila)
• Kin of irregular chiasm-like protein 2
• Kirrel2
• MGC15718
• NEPH3
• NEPH3Nephrin-like protein 3
• nephrin-like 3
• nephrin-like gene 1
• NLG1
• NLG1kin of irregular chiasm-like 2

Background

Kirrel2, also known as nephrin-like 3, nephrin-like gene 1 and filtrin, is a type I transmembrane protein belonging to the immunoglobulin superfamily. By alternative splicing, at least 5 isoforms that differ in their extracellular and/or intracellular regions have been described. Kirrel2 is expressed in the pancreas, lymph nodes, kidney glomerulus, as well as brain. The extracellular domains of human and mouse Kirrel2 share 86% amino acid sequence identity.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Kirrel2/NEPH3 Antibody (MAB2564)(2)

Publications using MAB2564

• Shabanipour S, Jiao X, Rahimi-Balaei M et al. Upregulation of Neural Cell Adhesion Molecule 1 and Excessive Migration of Purkinje Cells in Cerebellar Cortex Frontiers in Neuroscience 1/21/2022 [PMID: 35126044]
• Hornberg M, Gussing F, Berghard A, Bohm S Retinoic acid selectively inhibits death of basal vomeronasal neurons during late stage of neural circuit formation. J. Neurochem., 2009-06-10;110(4):1263-75. 2009-06-10 [PMID: 19519663] (IHC-Fr, Mouse)

Bioinformatics

• Gene Symbol: KIRREL2
• Uniprot:
  • Q6UWL6()