KIR3DL2/CD158k Antibody (539304)

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Human peripheral blood lymphocytes were stained with Mouse Anti-Human NCAM‑1/CD56 PE-conjugated Monoclonal Antibody (Catalog # FAB2408P) and either (A) Mouse Anti-Human KIR3DL2/CD158k Monoclonal Antibody (Catalog # ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow, CyTOF-ready
Clone
539304
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

KIR3DL2/CD158k Antibody (539304) Summary

Immunogen
BaF3 mouse pro-B cell line transfected with human KIR3DL2/CD158k
Accession # P43630
Specificity
Detects human KIR3DL2/CD158k in direct ELISAs.
Source
N/A
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
KIR3DL2
Purity
Protein A or G purified from hybridoma culture supernatant
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • CyTOF-ready
  • Flow Cytometry 2.5 ug/10^6 cells
Publications
Read Publications using
MAB2878 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Purity
Protein A or G purified from hybridoma culture supernatant
Reconstitution Instructions
Sterile PBS to a final concentration of 0.5 mg/mL.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for KIR3DL2/CD158k Antibody (539304)

  • killer cell immunoglobulin-like receptor 3DL2
  • CD158k
  • CL-5
  • killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2
  • KIR3DL2
  • NKAT4
  • NKAT-4
  • NKAT4A
  • NKAT4B
  • p140

Background

KIR3DL2 (3DL2, p140, CD158k) is a type I transmembrane protein of the p70 family of killer cell Ig-like receptors (KIR). KIR are expressed on CD56dim NK cells and T cell subsets where they participate in identifying normal and abnormal cells and regulating effector functions of the innate immune system (1-4). KIR are named for the number of Ig-like domains (2D or 3D) in the extracellular domain (ECD) and whether they have long or short (L, S) cytoplasmic tails. Like other inhibitory KIR, KIR3DL2 has two ITIM domains within its long tail (3). KIR3DL2 is diverse, with twelve alleles identified and as many as five single amino acid polymorphisms found in a single individual (4-6). Unlike most other KIR, gene transcripts of KIR3DL2 are expressed by all individuals (4). KIR3DL2 is present on the cell surface as a disulfide-linked homodimer of 70 kDa, 434 aa subunits (4). KIR3DL2 has shown peptide-specific binding to some HLA-A antigens, including A3 and A11 (4, 7, 8).  It also binds the abnormally folded HLA-B27 homodimer found in spondylarthritides, but not the normal heterodimer of HLA-B27 with beta 2‑microglobulin (9, 10). NK and CD4+ T cells from patients with spondylarthritides show increased KIR3DL2+ expression and may play a role in disease pathology (10). KIR3DL2 is also a marker for atypical mononuclear (Sezary) cells in the blood of patients with Sezary syndrome, an erythrodermic form of cutaneous T cell lymphoma (11). Human KIR3DL2 ECD shows 88-92% aa identity to KIR3DL2 of other primates. KIR receptors have no structural orthologs in non-primates, although mouse Ly-49 proteins are functional orthologs (3). KIR are highly related. The closest relative, KIR3DL1 shows 86% aa identity with KIR3DL2 within the ECD.
  1. Colonna, M. and J. Samaridis (1995) Science 268:405.
  2. Pende, D. et al. (1996) J. Exp. Med. 184:505.
  3. Lanier, L. L. (2005) Annu. Rev. Immunol. 23:225.
  4. Uhrberg, M. et al. (1997) Immunity 7:753.
  5. Meenaugh, A. et al. (2004) Tiss. Antigens 64:226.
  6. Kwon, D. et al. (2000) Mol. Cells 10:54.
  7. Dohring, C. et al. (1996) J. Immunol. 156:3098.
  8. Hansasuta, P. et al. (2004) Eur. J. Immunol. 34:1673.
  9. Kollnberger, S. et al. (2002) Arthritis Rheum. 46:2972.
  10. Chan, A. T. et al. (2005) Arthritis Rheum. 52:3586.
  11. Poszepczynska-Guigne, E. et al. (2004) J. Invest. Dermatol. 122:820.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for KIR3DL2/CD158k Antibody (MAB2878)(2)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: Depletion, Neutralization.


Filter By Application
Depletion
(1)
Neutralization
(1)
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Human
(2)
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Bioinformatics

Gene Symbol KIR3DL2
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