Kir3.4 Antibody [DyLight 650]

• Reactivity: Hu, Mu, Rt
• Applications: WB, ELISA
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: DyLight 650

Kir3.4 Antibody [DyLight 650] Summary

• Immunogen: potassium inwardly-rectifying channel, subfamily J, member 5. (Uniprot# P48544)
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: KCNJ5
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Immunogen affinity purified

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for Kir3.4 Antibody [DyLight 650]

• Cardiac inward rectifier
• CIRKIR3.4
• G protein-activated inward rectifier potassium channel 4
• GIRK-4
• GIRK4Kir3.4
• Heart KATP channel
• Inward rectifier K(+) channel Kir3.4
• inward rectifier K+ channel KIR3.4
• IRK-4
• KATP-1
• KATP1cardiac ATP-sensitive potassium channel
• LQT13
• Potassium channel, inwardly rectifying subfamily J member 5
• potassium inwardly-rectifying channel, subfamily J, member 5

Background

G-protein regulated inward-rectifier potassium channels (GIRK) are part of a superfamily of inward-rectifier K+ channels. To date four GIRK subunits, designated GIRK1-4 (also designated Kir3.1-4), have been identified in mammals, and GIRK5 has been found in Xenopus oocytes. GIRK channels exist in vivo both as homotetramers and heterotetramers. GIRK channels are modulated by G-proteins; they are also modulated by phosphatidylinositol 4,5-bisphosphate, intracellular sodium, ethanol and mechanical stretch. GIRK1, 2 and 3 are highly abundant in brain. In general, neuronal GIRK channels are involved in the regulation of the excitability of neurons and may contribute to the resting potential.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: KCNJ5