KIR2DS1/CD158h Antibody (1127B) [Biotin]

• Reactivity: Hu
• Applications: Flow
• Clone: 1127B
• Clonality: Monoclonal
• Host: Rabbit
• Conjugate: Biotin

KIR2DS1/CD158h Antibody (1127B) [Biotin] Summary

• Additional Information: Recombinant Monoclonal Antibody
• Immunogen: HEK293 human embryonic kidney cell line transfected with human KIR2DS1/CD158h
  Met1-His245
  Accession # Q14954
• Specificity: Detects human KIR2DS1/CD158h in flow cytometry. Clone 1127B recognizes KIR2DS1 and some alleles of KIR2DL1, both members of the killer cell immunoglobulin-like receptor (KIR) family. Because Clone 1127B displays partial cross-reactivity with KIR2DL1, co-staining with Mouse Anti-Human KIR2DL1 Clone 143211 (Catalog # FAB1844F) is recommended.
• Isotype: IgG
• Clonality: Monoclonal
• Host: Rabbit
• Gene: KIR2DS1
• Purity: Protein A or G purified from cell culture supernatant

Applications/Dilutions

• Dilutions:
  • Flow Cytometry
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: PBS
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified from cell culture supernatant

Alternate Names for KIR2DS1/CD158h Antibody (1127B) [Biotin]

• killer cell immunoglobulin-like receptor 2DS1
• CD158a
• CD158h
• EB6ActI
• killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1
• KIR2DS1
• p50.1

Background

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. (provided by RefSeq)

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: KIR2DS1