KIR2DS1/CD158h Products

Antibodies
KIR2DS1/CD158h Antibody (1127 ...
KIR2DS1/CD158h Antibody (1127B) [U...
MAB8887
Species: Hu
Applications: Flow
Host: Rabbit Monoclonal
Lysates
KIR2DS1/CD158h Overexpression ...
KIR2DS1/CD158h Overexpression Lysa...
NBP2-07321
Applications: WB
RNAi
KIR2DS1/CD158h RNAi
KIR2DS1/CD158h RNAi
H00003806-R02
Species: Hu
Applications: RNAi, RNAi SP

Description

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. (provided by RefSeq)

Bioinformatics

Entrez Human
Uniprot Human
Product By Gene ID 3806
Alternate Names
  • killer cell immunoglobulin-like receptor 2DS1
  • CD158a
  • CD158H
  • p50.1
  • killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1

PTMs for KIR2DS1/CD158h

Learn more about PTMs related to KIR2DS1/CD158h.

Glycosylation
Citrullination

Bioinformatics Tool for KIR2DS1/CD158h

Discover related pathways, diseases and genes to KIR2DS1/CD158h. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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