KIR2DL3/CD158b2 Antibody (GL183) - BSA Free

• Reactivity: Hu
• Applications: Flow, IP
• Clone: GL183
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 1 mg/ml

KIR2DL3/CD158b2 Antibody (GL183) - BSA Free Summary

• Immunogen: NK cell clone E57
• Specificity: NB100-65875 recognizes the human CD158b cell surface antigen, a 58kD glycoprotein expressed by a subset of NK cells (also known as p58.2 antigen). This antibody also recognizes a 50kD molecule, which is highly homologous to p58.2 in the extracellular domain, but has a shorter cytoplasmic tail. Both molecules are members of the newly described natural killer cell receptor family. CD158b functions as a receptor specific for HLA Class I molecules, including Cw3 and related HLA-C alleles. This antibody can restore the lysis by human NK clones of otherwise lysis protected targets expressing Cw3.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: KIR2DL3
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Flow Cytometry 1:10-1:50
  • Immunoprecipitation 1:10-1:500

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.09% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Protein A or G purified

Alternate Names for KIR2DL3/CD158b2 Antibody (GL183) - BSA Free

• CD158 antigen-like family member B2
• CD158b2 antigen
• CD158b2
• CD158B2CD158b
• cl-6
• killer cell immunoglobulin-like receptor 2DL3
• killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
• Killer inhibitory receptor cl 2-3
• KIR-023GB
• KIR2DL3
• KIRCL23
• KIR-K7b
• KIR-K7c
• MGC129943
• MHC class I NK cell receptor
• natural killer associated transcript 2
• natural killer cell inhibitory receptor KIR2DL3
• Natural killer-associated transcript 2
• NKAT
• NKAT2
• NKAT-2
• NKAT2A
• NKAT2B
• NKAT2GL183
• NK-receptor
• p58 natural killer cell receptor clone CL-6
• p58 NK receptor CL-6
• p58
• p58.2 MHC class-I specific NK receptor
• p58.2 MHC class-I-specific NK receptor

Background

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: KIR2DL3
• Entrez:
  • 3804(Human)
• Uniprot:
  • P43628()
  • P43628()