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Reacts with extracellular domain of the KIR2DL3, a member of the killer cell immunoglobulin-like receptor(KIR) family. The KIR family consists of transmembrane glycoproteins of the Ig superfamily expressed on human NK cells and a subset of human T cells which they are involved in recognition of either MHC class I molecules or unknown ligand on target cells and inhibit cytotoxic activities.