KCC3/SLC12A6 Antibody

Images

 
Western Blot: KCC3/SLC12A6 Antibody [NBP1-06044] - (0.1ug/ml) staining of Human Heart lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Immunohistochemistry-Paraffin: KCC3/SLC12A6 Antibody [NBP1-06044] - (2.5ug/ml) staining of paraffin embedded Human Heart. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, IHC, IHC-P, PEP-ELISA
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
0.5 mg/ml

Order Details

KCC3/SLC12A6 Antibody Summary

Immunogen
Peptide with sequence SRHIDVCSKTKE corresponding to internal region according to NP_001035959.1, NP_001035960.1, NP_001035961.1, NP_001035962.1, NP_005126.1, NP_598408.1.
Epitope
SRHIDVCSKTKE
Specificity
This antibody is expected to recognise all 6 reported isofoms (NP_598408.1; NP_005126.1; NP_001035959.1; NP_001035960.1; NP_001035961.1; NP_001035962.1; );
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
SLC12A6
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 0.1 - 0.3 ug/ml
  • Immunohistochemistry 2 - 4 ug/ml
  • Immunohistochemistry-Paraffin 2 - 4 ug/ml
  • Peptide ELISA Detection limit 1:16000
Application Notes
WB: Approx. 120 kDa band observed in human heart and kidney lysates (calculated MW ranging 121-128 kDa band according to NP_598408.1; NP_005126.1; NP_001035959.1; NP_001035960.1; NP_001035961.1; NP_001035962.1). IHC-P: Human heart shows staining of myocardial fibrils in transverse section.
Control
KCC3/SLC12A6 Knockout HeLa Cell Lysate
Publications
Read Publication using NBP1-06044.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
Tris (pH 7.3), 0.5% BSA
Preservative
0.02% Sodium Azide
Concentration
0.5 mg/ml
Purity
Immunogen affinity purified

Alternate Names for KCC3/SLC12A6 Antibody

  • ACCPN
  • agenesis of corpus callosum and peripheral neuropathy (Andermann syndrome)
  • DKFZp434D2135
  • EC 1.2.4.1
  • EC 6.1.1.3
  • Electroneutral potassium-chloride cotransporter 3
  • KCC3
  • KCC3A
  • KCC3B
  • KCC3potassium chloride cotransporter 3
  • K-Cl cotransporter 3
  • potassium chloride cotransporter KCC3a-S3
  • potassium-chloride transporter-3a
  • potassium-chloride transporter-3b
  • SLC12A6
  • solute carrier family 12 (potassium/chloride transporters), member 6
  • solute carrier family 12 member 6

Background

This gene is a member of the K-Cl cotransporter (KCC) family. K-Cl cotransporters are integral membrane proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The proteins encoded by this gene are activated by cell swelling induced by hypotonic conditions. Alternate splicing results in multiple transcript variants encoding different isoforms. Mutations in this gene are associated with agenesis of the corpus callosum with peripheral neuropathy. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for KCC3/SLC12A6 Antibody (NBP1-06044)(1)

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol SLC12A6
Entrez
Uniprot