Kallikrein 6/Neurosin Antibody

Images

 
Western Blot: Kallikrein 6/Neurosin Antibody [NBP1-06497] - Human salivary lysates.
Immunocytochemistry/ Immunofluorescence: Kallikrein 6/Neurosin Antibody [NBP1-06497] - Kallikrein 6 antibody was tested in Hek293 cells with DyLight 488 (green). Nuclei and alpha-tubulin were counterstained with DAPI ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, ICC/IF
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

Kallikrein 6/Neurosin Antibody Summary

Immunogen
Full length human Kallikrein 6 protein expressed in E. coli. [Swiss-Prot# Q92876]
Localization
Cytoplasm
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
KLK6
Purity
Unpurified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunocytochemistry/Immunofluorescence 1:20
  • Western Blot 1:1000
Application Notes
This Kallikrein 6 antibody is useful for Immunocytochemistry/Immunofluorescence and Western blot, where a band is seen at ~38kDa due to glycosylation. In ICC/IF cytoplasmic staining was observed. The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
38 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Control
Kallikrein 6/Neurosin Overexpression Lysate

Reactivity Notes

Human. Immunogen sequence has 85% identity with canine, 82% identity with horse and 80% identity with bovine.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
Whole antisera
Preservative
0.1% Sodium Azide
Purity
Unpurified

Alternate Names for Kallikrein 6/Neurosin Antibody

  • Bssp
  • EC 3.4.21
  • EC 3.4.21.-
  • hK6
  • kallikrein 6 (neurosin, zyme)
  • Kallikrein 6
  • kallikrein-6
  • kallikrein-related peptidase 6
  • KLK6
  • Klk7
  • Neurosin
  • Protease M
  • protease, serine, 18
  • PRSS18
  • PRSS9
  • PRSS9MGC9355
  • Serine protease 18
  • Serine protease 9
  • SP59
  • Zyme

Background

Kallikrein 6 (KLK6 or kallikrein-related peptidase 6) is a serine protease with trypsin-like properties and belongs to family of KLKs that serves multiple physiological functions including blood pressure regulation, semen liquefaction, skin desquamation etc. and have also been known to implicate in several pathological processes such as tumorigenesis/metastasis, angiogenesis, neurological diseases etc. KLK6 shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins including fibronectin, laminin, vitronectin as well as collagen. KLK6 exerts degradation mediated prevention of alpha-synuclein polymerization, suggesting its role in synucleinopathies such as Parkinson disease. KLK6 has also been proposed to involve in regulation of axon outgrowth following spinal cord injury and in pathways including inflammation, receptor activation and apoptosis regulation. Expressed at highest levels brain among other normal tissues, KLK6 has been extensively studied in cancer as well as neurodegenerative diseases wherein it has emerged as a novel biomarkers for prognosis, diagnosis and therapeutic intervention.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

Other Available Formats

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Bioinformatics

Gene Symbol KLK6
Entrez
Uniprot