Kallikrein 3/PSA Antibody

Product Discontinued

Kallikrein 3/PSA Antibody Summary

• Immunogen: Residues 247-261 [VHYRKWIKDTIVANP] of the human KLK 3 protein
• Specificity: Human KLK3 protein.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: KLK3
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100-1:2000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
  • Immunoprecipitation 1:10-1:500
  • Western Blot 1:100-1:2000
• Application Notes: Western blot The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
• Theoretical MW: 29 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.02% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for Kallikrein 3/PSA Antibody

• APS seminin
• EC 3.4.21
• EC 3.4.21.77
• Gamma-seminoprotein
• hK3
• Kallikrein 3
• kallikrein 3, (prostate specific antigen)
• Kallikrein-3
• kallikrein-related peptidase 3
• KLK2A1
• KLK3
• P-30 antigen
• prostate specific antigen
• prostate-specific antigen
• PSA semenogelase
• PSA
• Semenogelase
• Seminin

Background

Kallikreins are a subgroup of serine proteases and are implicated in carcinogenesis. KLK 3 (also known as prostate specific antigen) is a marker for prostatic cancer and is involved in the pathogenesis and/or progression of prostate, breast, and possibly other malignancies. PSA is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum levels of this protein are useful in the diagnosis and monitoring of prostatic carcinoma

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Kallikrein 3/PSA Antibody (NB200-135)(2)

Publications using NB200-135

• Engel BJ, Constantinou PE, Sablatura LK et al. Multilayered, Hyaluronic Acid-Based Hydrogel Formulations Suitable for Automated 3D High Throughput Drug Screening of Cancer-Stromal Cell Cocultures. Adv Healthc Mater 2015-06-09 [PMID: 26059746]
• Tollner TL, Yudin AI, Treece CA et al. Macaque sperm coating protein DEFB126 facilitates sperm penetration of cervical mucus. Hum Reprod. 2008-11-01 [PMID: 18658160] (WB, Human)
  
  Details:
  WB (human sperm cells), Fig. 8J.

Bioinformatics

• Gene Symbol: KLK3
• Entrez:
  • 354(Human)
• Uniprot:
  • P07288()