Kallikrein 3/PSA Antibody (8A6cc)

Product Discontinued

Kallikrein 3/PSA Antibody (8A6cc) Summary

• Immunogen: Hybridoma clone has been derived from hybridization of Sp2/0 myeloma cells with spleen cells of Balb/c mice immunized with Human PSA antigen purified from seminal plasma.
• Epitope: Epitope 1
• Localization: Cytoplasmic and Secreted
• Specificity: Specific for free PSA, epitope 1. No cross reactivity with human kallikrein 2.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Gene: KLK3
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Lateral Flow Assay
  • Sandwich ELISA 1:100-1:2000
• Application Notes: Recommended pairs for detection of free PSA (capture-detection): NB110-7917 - NB120-10185, or NB120-10185 - NB110-7917

Packaging, Storage & Formulations

• Storage: Store at 4C. Do not freeze.
• Buffer: PBS (pH 7.4)
• Preservative: 0.09% Sodium Azide
• Purity: Protein A purified

Alternate Names for Kallikrein 3/PSA Antibody (8A6cc)

• APS seminin
• EC 3.4.21
• EC 3.4.21.77
• Gamma-seminoprotein
• hK3
• Kallikrein 3
• kallikrein 3, (prostate specific antigen)
• Kallikrein-3
• kallikrein-related peptidase 3
• KLK2A1
• KLK3
• P-30 antigen
• prostate specific antigen
• prostate-specific antigen
• PSA semenogelase
• PSA
• Semenogelase
• Seminin

Background

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates two transcript variants encoding different isoforms. Additional transcript variants have been described, but it is unclear if these transcripts are normally expressed or if they are specific to benign or malignant tumors.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: KLK3
• Entrez:
  • 354(Human)