Kallikrein 3/PSA Antibody (8A6)

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications S-ELISA
Clone
8A6
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Kallikrein 3/PSA Antibody (8A6) Summary

Immunogen
Human PSA antigen purified from semenal plasma.
Localization
Cytoplasmic and Secreted
Specificity
Specific for free PSA, epitope 1. No cross reactivity with human kallikrein 2.
Isotype
IgG2a
Clonality
Monoclonal
Host
Mouse
Gene
KLK3
Purity
Protein A purified
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Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Sandwich ELISA 1:100-1:2000
Application Notes
Recommended pairs for detection of free PSA (capture-detection): NB120-10185 - NB110-7917, NB110-7920 - NB110-7917, NB110-7917 - NB120-10185. Best Pair: NB110-7917 - NB120-10185.

Reactivity Notes

Cross-reacts with Human.

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
PBS (pH 7.4)
Preservative
0.09% Sodium Azide
Purity
Protein A purified

Alternate Names for Kallikrein 3/PSA Antibody (8A6)

  • APS seminin
  • EC 3.4.21
  • EC 3.4.21.77
  • Gamma-seminoprotein
  • hK3
  • Kallikrein 3
  • kallikrein 3, (prostate specific antigen)
  • Kallikrein-3
  • kallikrein-related peptidase 3
  • KLK2A1
  • KLK3
  • P-30 antigen
  • prostate specific antigen
  • prostate-specific antigen
  • PSA semenogelase
  • PSA
  • Semenogelase
  • Seminin

Background

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates two transcript variants encoding different isoforms. Additional transcript variants have been described, but it is unclear if these transcripts are normally expressed or if they are specific to benign or malignant tumors.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol KLK3
Entrez