Kallikrein 1 Antibody

Product Discontinued

Kallikrein 1 Antibody Summary

• Immunogen: Peptide with sequence C-FNTWIRETMAEND corresponding to C-Terminus according to Uniprot Mouse NP_034769.4.
• Epitope: FNTWIRETMAEND - C Terminus
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: KLK1
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunoprecipitation 1:10 - 1:500
  • Peptide ELISA Detection limit 1:4000
• Application Notes: WB: Preliminary experiments gave an approx. 55 kDa band in mouse liver, heart and testis lysates after 0.3 ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 28.8 kDa band according to NP_034769.4. The 55 kDa band was successfully blocked by incubation with the immunizing peptide.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Notes

Please note, this antibody is considered Innovators Grade. Innovators Grade antibodies are generally unvalidated and require additional characterization for most new species/applications. Novus has made these antibodies available through our Innovators Reward program. Complete an online review with image, detailing your positive or negative results. In return, you receive a discount voucher for 100% of the purchase price of the reviewed product. Please contact us at innovators@novusbio.com for more details.

Alternate Names for Kallikrein 1 Antibody

• EC 3.4.21
• EC 3.4.21.35
• glandular kallikrein 1
• hK1
• Kallikrein 1
• kallikrein 1, renal/pancreas/salivary
• kallikrein serine protease 1
• kallikrein-1
• Kidney/pancreas/salivary gland kallikrein
• KLK1
• Klk6
• KLKR
• Tissue kallikrein

Background

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. This protein is functionally conserved in its capacity to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Kallikrein 1 Antibody (NBP1-49884)(1)

Publication using NBP1-49884

• Christophi GP, Isackson PJ, Blaber S et al. Distinct promoters regulate tissue-specific and differential expression of kallikrein 6 in CNS demyelinating disease. J Neurochem 2004-12-01 [PMID: 15584920]

Bioinformatics

• Gene Symbol: KLK1
• Entrez:
  • 16612(Mouse)
• Uniprot:
  • NP_034769.4(Mouse)