JNK1/JNK2 Antibody (252323) [mFluor Violet 450 SE]

• Reactivity: Hu, Mu, Rt
• Applications: WB, ICC/IF
• Clone: 252323
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: mFluor Violet 450 SE

JNK1/JNK2 Antibody (252323) [mFluor Violet 450 SE] Summary

• Immunogen: E. coli-derived recombinant human JNK1 isoform 2
• Specificity: Detects human, mouse, and rat p46 and p54 JNK1/JNK2. Does not detect recombinant JNK3.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Purity: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified from hybridoma culture supernatant

Notes

mFluor(TM) is a trademark of AAT Bioquest, Inc. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for JNK1/JNK2 Antibody (252323) [mFluor Violet 450 SE]

• c-Jun N-terminal kinase 1
• JNK
• JNK1
• JNK1/JNK2
• JNK1A2
• JNK21B1/2
• JNK-46
• JUN N-terminal kinase
• MAP kinase 8
• mitogen-activated protein kinase 8
• PRKM8
• SAPK1
• SAPK1C
• Stress-activated protein kinase 1
• stress-activated protein kinase 1c

Background

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Apr 2016]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.