JNK1/JNK2 Products

Description

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Apr 2016]

Bioinformatics

Product By Gene ID	5599
Alternate Names	c-Jun N-terminal kinase 1 JNK JNK1 JNK1A2 JNK21B1/2 JNK-46 JUN N-terminal kinase MAP kinase 8 mitogen-activated protein kinase 8 PRKM8 SAPK1 SAPK1C Stress-activated protein kinase 1 stress-activated protein kinase 1c