JNK1/JNK2 Antibody (252323) [Janelia Fluor® 549]

• Reactivity: Hu, Mu, Rt
• Applications: WB, ICC/IF
• Clone: 252323
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Janelia Fluor 549

JNK1/JNK2 Antibody (252323) [Janelia Fluor® 549] Summary

• Immunogen: E. coli-derived recombinant human JNK1 isoform 2
• Specificity: Detects human, mouse, and rat p46 and p54 JNK1/JNK2. Does not detect recombinant JNK3.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Purity: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified from hybridoma culture supernatant

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for JNK1/JNK2 Antibody (252323) [Janelia Fluor® 549]

• c-Jun N-terminal kinase 1
• JNK
• JNK1
• JNK1/JNK2
• JNK1A2
• JNK21B1/2
• JNK-46
• JUN N-terminal kinase
• MAP kinase 8
• mitogen-activated protein kinase 8
• PRKM8
• SAPK1
• SAPK1C
• Stress-activated protein kinase 1
• stress-activated protein kinase 1c

Background

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Apr 2016]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.