JMJD6/PSR Antibody

Product Discontinued

JMJD6/PSR Antibody Summary

• Immunogen: Antibody was raised against a 15 amino acid synthetic peptide from near the amino terminus of human JMJD6. The immunogen is located within amino acids 70 - 120 of JMJD6.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: JMJD6
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100-1:2000
  • Immunocytochemistry/ Immunofluorescence 20 ug/ml
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
  • Western Blot 1:100-1:2000

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.02% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for JMJD6/PSR Antibody

• bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
• EC 1.14.11
• EC 1.14.11.-
• Histone arginine demethylase JMJD6
• JmjC domain-containing protein 6
• JMJD6
• jumonji domain containing 6
• Jumonji domain-containing protein 6
• KIAA0585PSR
• Lysyl-hydroxylase JMJD6
• Peptide-lysine 5-dioxygenase JMJD6
• Phosphatidylserine receptorPTDSR
• Protein PTDSR
• PSR
• PTDSR
• PTDSR1

Background

The jumonji domain-containing protein (JMJD) family is defined by the presence of the JmjC domain that is observed in several diverse species. JMJD6 was initially identified as a membrane protein that participates in phagocytosis but recent studies have shown that it has other functions when it is expressed in the cytosol and nucleus. JMJD6 is thought to play important roles in regulation of development and differentiation as knockdown experiments in mice resulted in neonatal lethality with severe defects in the morphology of numerous organs. JMJD6 also can catalyze the lysyl-hydroxylation of U2AF65, a protein involved with RNA splicing, suggesting that some of the functions attributed to JMJD6 may be due to its regulatory activity of RNA splicing.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: JMJD6
• Uniprot:
  • Q6NYC1(Human)