Jak1 Antibody

Product Discontinued

Jak1 Antibody Summary

• Immunogen: Recombinant protein encompassing a sequence within the C-terminus region of human JAK1. The exact sequence is proprietary.
• Localization: Membrane
• Predicted Species: Rat (98%), Porcine (100%), Bovine (99%), Rhesus Macaque (100%), Chicken (93%), Canine (99%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: JAK1
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence 1:100-1:1000
  • Western Blot 1:500-1:3000
• Theoretical MW: 133 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Xenopus laevis (85%).

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: 0.1M Tris (pH 7), 0.1M Glycine, 10% Glycerol
• Preservative: 0.01% Thimerosal
• Purity: Protein A purified

Alternate Names for Jak1 Antibody

• EC 2.7.10
• Jak1
• JAK-1
• JAK1Atyrosine-protein kinase JAK1
• JAK1B
• Janus kinase 1EC 2.7.10.2
• JTK3

Background

JAK1 (Janus kinase 1) a 130 kD non-receptor protein tyrosine kinase family and a member of the JAK subfamily is a widely expressed, membrane associated kinase involved in signal transduction pathways from interferon alpha, beta, and gamma receptors, all class II receptors, cytokine receptors that utilize the common gamma chain subunit for signaling, and cytokine receptors that utilize the gp130 subunit for signaling. JAK1 phosphorylates Stat proteins and SHP2. This kinase is constitutively expressed, but expression can be increased with interferon- alpha and interferon- gamma stimulation through transcription. JAK1 activity is increased by cytokine receptor-ligand binding and can be decreased by SOCS proteins, SHP2 protein phosphatase, and PPAR agonists. JAK1 is modified by phosphorylation and has been shown to associate with IFN- alpha receptor beta chain, IFN- gamma receptor alpha chain, IL-10 receptor alpha chain, IL-2 receptor beta chain, and IL-4 receptor alpha chain. The Poly6044 antibody recognizes the N-terminal region of human JAK1 and has been shown to be useful for Western blotting.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause reproductive toxicity with developmental effects.  For more information go to www.P65Warnings.ca.gov.

Bioinformatics

• Gene Symbol: JAK1