ITFG1 Antibody (936234) [Alexa Fluor® 750]

• Reactivity: Hu
• Applications: WB
• Clone: 936234
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 750

ITFG1 Antibody (936234) [Alexa Fluor® 750] Summary

• Immunogen: Human embryonic kidney cell line HEK293-derived human ITFG1
  Met1-Ile566
  Accession # Q8TB96
• Specificity: Detects human ITFG1 in direct ELISAs.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for ITFG1 Antibody (936234) [Alexa Fluor® 750]

• CDA08
• integrin alpha FG-GAP repeat containing 1,2310047C21Rik
• Integrin-alpha FG-GAP repeat-containing protein 1
• ITFG1
• Protein TIP
• T-cell immunomodulatory protein
• TIP
• TIPT cell immunomodulatory protein

Background

Integrin-alpha FG-GAP repeat-containing protein 1 (ITFG1), also known as T cell immunomodulatory protein (TIP), was initially identified using bioinformatics and high-throughput cell-based screening assays to isolate novel factors involved in T cell biology.  A ubiquitously expressed 98 kDa glycoprotein, ITFG1 contains an N-terminal signal peptide and a C-terminal transmembrane domain flanking twelve potential N-linked glycosylation sites.  Human and mouse T cells treated with ITFG1 in vitro secreted the cytokines IFN-g, TNF-a and IL-10, while in vivo ITFG1 was protective in a mouse acute graft-versus-host disease (GVHD) model.  Over amino acids (aa) 1-566, human ITFG1 shares 89% and 88% aa identity with mouse and rat ITFG1, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.