Integrin beta 6 Antibody (CSbeta6) [mFluor Violet 610 SE]

Integrin beta 6 Antibody (CSbeta6) [mFluor Violet 610 SE] [NBP2-29800MFV610] - Vial of mFluor Violet 610 conjugated antibody. mFluor Violet 610 is optimally excited at 421 nm by the Violet laser (405 nm) and has an emission maximum of 613 nm.

• Reactivity: Hu, Rt, Pm, Rb
• Applications: Flow, IHC, IP, CyTOF-ready
• Clone: CSbeta6
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: mFluor Violet 610 SE

Integrin beta 6 Antibody (CSbeta6) [mFluor Violet 610 SE] Summary

• Immunogen: beta 6 knockout mice have been immunized with recombinant secreted human alpaVbeta6.
• Specificity: Monoclonal antibody MAB2076Z, raised by immunizing beta6 knockout mice with recombinant secreted human alphavbeta6, is useful for flow cytometry and immunoprecipitation in all species tested, including mouse. It also works well for immunohistochemistry of acetone-fixed tissues in several species, including rat, rabbit, monkey, and human. The antibody does not work well for immunohistochemistry of mouse tissue. This antibody does not recognize the aV subunit and does not react with alphaV integrins other than alphavbeta6. Because the antibody is not effective in western Blot, it is unknown whether the epitope recognized by the antibody localizes to the alphavbeta6 heterodimer or to the beta6 subunit only.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: ITGB6
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • CyTOF-ready
  • Flow Cytometry
  • Immunohistochemistry
  • Immunoprecipitation
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified

Alternate Names for Integrin beta 6 Antibody (CSbeta6) [mFluor Violet 610 SE]

• Integrin beta 6
• integrin beta-6
• integrin, beta 6
• ITGB6

Background

Integrin alpha-V/beta-6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: ITGB6