Insulin R/CD220 Antibody (MA-20) [DyLight 488]

Product Discontinued

Insulin R/CD220 Antibody (MA-20) [DyLight 488] Summary

• Immunogen: Highly purified Insulin Receptor (alpha-subunit) from human term placentas. [UniProt# P06213]
• Localization: Membrane; single pass type I membrane protein.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Gene: INSR
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Block/Neutralize
  • ELISA
  • Immunoprecipitation
  • Western Blot
• Application Notes: This Insulin Receptor (MA-20) antibody is useful for ELISA, Immunoprecipitation, Western blot and Blocking/Neutralizing assays.

Reactivity Notes

Human and rat. Mouse reactivity reported in scientific literature (PMID: 24389353)

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein G purified

Notes

Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for Insulin R/CD220 Antibody (MA-20) [DyLight 488]

• CD 220
• CD220 antigen
• CD220
• EC 2.7.10
• EC 2.7.10.1
• HHF5
• INSR
• Insulin R
• insulin receptor
• InsulinR
• IR

Background

The insulin receptor is functionally important for negative cooperativity, down-regulation, and beta-subunit tyrosine kinase activity. There are two recognized epitopes of the alpha-subunit. One epitope is close to the insulin-binding site and plays a role in insulin-induced negative cooperativity and down-regulation. The other site (recognized by the monoclonal MA-20 antibody) is at a distance from the insulin-binding site, where it only plays a role in down-regulation. Both epitopes appear to be independent of insulin receptor tyrosine kinase activity.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: INSR