IL6R Antibody (AP-MAB0848)

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Product Details

Summary
Reactivity MuSpecies Glossary
Applications B/N, Flow, IP, CyTOF-ready
Clone
AP-MAB0848
Clonality
Monoclonal
Host
Rat
Conjugate
Unconjugated
Concentration
1.0 mg/ml

Order Details

IL6R Antibody (AP-MAB0848) Summary

Immunogen
Mouse recombinant IL-6R alpha chain
Isotype
IgG2
Clonality
Monoclonal
Host
Rat
Gene
IL6R
Purity
Protein A or G purified
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Applications/Dilutions

Dilutions
  • Blocking/Neutralizing 50-200 molar excess
  • Flow Cytometry 1:10-1:1000
  • Immunoprecipitation 1:10-1:500
  • CyTOF-ready
Application Notes
Extremely low level of LPS (< 0.002EU/ug IgG)

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
A 0.2 um filtered solution in PBS - Azide free
Preservative
No Preservative
Concentration
1.0 mg/ml
Purity
Protein A or G purified

Alternate Names for IL6R Antibody (AP-MAB0848)

  • CD126 antigen
  • CD126
  • gp80
  • IL-6 receptor subunit alpha
  • IL-6R 1
  • IL-6R subunit alpha
  • IL-6R-1
  • IL6RA
  • IL-6RA
  • IL-6R-alpha
  • interleukin 6 receptor alpha subunit
  • interleukin 6 receptor
  • interleukin-6 receptor subunit alpha
  • Membrane glycoprotein 80
  • MGC104991

Background

CD126 is an 80 kD IL-6 receptor alpha chain also known as IL-6R. It is a member of the immunoglobulin superfamily that is expressed on activated T and B cells, monocytes, hepatocytes, and plasma cells. High affinity IL-6 receptors are formed by the non-covalent association of CD126 and the IL-6 receptor beta chain (CD130 or gp130). CD126 binds IL-6 with low affinity, but does not signal. The beta chain (gp130, CD130) does not bind IL-6 by itself, but associates with the alpha-chain/IL-6 complex to initiate signal transduction. IL-6 binding to the receptor complex results in the stimulation of B and T cells, and hematopoietic precursor stimulation and differentiation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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FAQs for IL6R Antibody (NBP1-06670). (Showing 1 - 1 of 1 FAQ).

  1. I am looking for an antibody to detect murine IL6 receptor and would like to use it to block the receptor in vivo in mouse. Your data sheet briefly states, that this antibody can be used for "Blocking/Neutralizing 50-200 molar excess" - but not more infor
    • The blocking assay was performed using murine IL-6Ra over-expressing mouse fibroblasts. NBP1-06670 blocks IL-6 induced cell proliferation in a dose dependent manner, however no in vivo testing has been performed in house.

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Bioinformatics

Gene Symbol IL6R
Entrez
Uniprot