IL-12 R beta 1 Antibody


There are currently no images for IL-12 R beta 1 Antibody (AF1998).

Every product we sell is backed by Novus' 100% Guarantee. If you have used this product, please submit your images and reviews to earn reward points.

Product Details

Reactivity MuSpecies Glossary
Applications WB

Order Details

View Available Conjugates
View Available Formulations

IL-12 R beta 1 Antibody Summary

S. frugiperda insect ovarian cell line Sf 21-derived recombinant mouse IL-12 R beta 1
Accession # Q60837
Detects mouse IL-12 R beta 1 in direct ELISAs and Western blots. In these formats, approximately 20% cross‑reactivity with recombinant human IL-12 R beta 1 is observed.
Immunogen affinity purified
Purity Statement
Antigen Affinity-purified
Endotoxin Note
<0.10 EU per 1 μg of the antibody by the LAL method.
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.


  • Western Blot 0.1 ug/mL
Read Publication using
AF1998 in the following applications:

Packaging, Storage & Formulations

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
No Preservative
Immunogen affinity purified
Reconstitution Instructions
Reconstitute at 0.2 mg/mL in sterile PBS.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for IL-12 R beta 1 Antibody

  • CD212 antigen
  • CD212
  • IL-12 R beta 1
  • IL-12 receptor beta component
  • IL-12 receptor subunit beta-1
  • IL12R beta 1
  • IL-12R subunit beta-1
  • IL12R
  • IL12RB
  • IL12RB1
  • IL-12Rb1
  • IL-12R-BETA1
  • IL-12R-beta-1
  • interleukin 12 receptor, beta 1
  • interleukin-12 receptor beta-1 chain
  • interleukin-12 receptor subunit beta-1
  • MGC34454


IL-12 R beta 1 is a 100 kDa type I transmembrane protein that belongs to the gp130/G-CSF R family of cytokine receptors. IL-12 R beta 1 is a common subunit of both the IL‑12 and IL-23 receptor complexes which play distinct but related roles in T cell mediated inflammatory reactions (1, 2). Mature mouse IL-12 R beta 1 contains a 546 amino acid (aa) extracellular domain (ECD) with five fibronectin type III repeats, and a 147 aa cytoplasmic domain (3). Within the ECD, mouse IL-12 R beta 1 shares 85% and 52% aa sequence identity with rat and human IL-12 R beta 1, respectively. It shares 16% - 21% aa sequence identity with the ECDs of mouse gp130, LIF R, G-CSF R, and IL-23 R. IL-12 and IL-23 are disulfide linked heterodimeric cytokines that share a common p40 subunit (1, 2). IL-12 R beta 1 interacts with p40 at low affinity but does not transmit signals (3). Increased ligand binding affinity and signaling capacity are gained by association of IL-12 R beta 1 with either IL-12 R beta 2 or IL-23 R (4 - 6). IL-12 R beta 2 and IL-23 R are the signal transducing components of these receptor complexes (4, 7). IL-12 R beta 1 is expressed on activated T cells, NK cells, B cells, macrophages, and microglia (8 - 10). IL-12 induced signaling promotes the development of naïve T cells into IFN-beta producing Th1 cells (11). IL-23 contributes to chronic inflammation by inducing the production of IL-17 by memory T cells (12). Naturally occurring homodimers of p40 can function as antagonists of IL-12 and IL‑23 and can also induce macrophage chemotaxis in the absence of IL-12 R beta 2 (13, 14).

  1. Becker, C. et al. (2005) Inflamm. Bowel Dis. 11:755.
  2. Hunter, C.A. (2005) Nat. Rev. Immunol. 5:521.
  3. Chua, A.O. et al. (1995) J. Immunol. 155:4286.
  4. Parham, C. et al. (2002) J. Immunol. 168:5699.
  5. Wu, C. et al. (1997) J. Immunol. 159:1658.
  6. Zou, J. et al. (1997) J. Biol. Chem. 272:6073.
  7. Presky, D.H. et al. (1996) Proc. Natl. Acad. Sci. 93:14002.
  8. Wu, C. et al. (1997) Eur. J. Immunol. 27:147.
  9. Airoldi, I. et al. (2000) J. Immunol. 165:6880.
  10. Li, J. et al. (2003) J. Neurol. Sci. 215:95.
  11. Schmitt, E. et al. (1994) Eur. J. Immunol. 24:793.
  12. Yen, D. et al. (2006) J. Clin. Invest. 116:1310.
  13. Shimozato, O. et al. (2006) Immunology 117:22.
  14. Russell, T.D. et al. (2003) J. Immunol. 171:6866.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Customers Who Viewed This Item Also Viewed...

Species: Hu
Applications: WB
Species: Mu
Applications: BA
Species: Mu
Applications: ELISA
Species: Hu, Mu
Applications: CyTOF-ready, ICFlow, Simple Western, WB
Species: Hu
Applications: CyTOF-ready, Flow, Neut, WB
Species: Hu
Applications: Flow, ICC/IF, IHC, IHC-P, WB
Species: Mu
Applications: ELISA
Species: Hu
Applications: BA
Species: Mu
Applications: ELISA
Species: Hu
Applications: ELISA
Species: Hu
Applications: CyTOF-ready, Flow, Neut, WB
Species: Hu, Mu
Applications: Flow-CS, Flow, IHC, IHC-P, Simple Western, WB
Species: Hu
Applications: BA
Species: Mu
Applications: BA
Species: Hu, Pm, Mu, Pm, Rt
Applications: ChIP, ICC/IF, IHC, IHC-P, IP, KD, WB
Species: Hu, Mu, Rt
Applications: Flow, ICC/IF, IHC, IHC-P, WB
Species: Hu, Mu, Rt
Applications: B/N, Func-Inh, In vitro, In vivo
Species: Mu
Applications: WB

Publications for IL-12 R beta 1 Antibody (AF1998)(1)

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: Western Blot.

Filter By Application
Western Blot
All Applications
Filter By Species
All Species

Reviews for IL-12 R beta 1 Antibody (AF1998) (0)

There are no reviews for IL-12 R beta 1 Antibody (AF1998). By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount.
  • Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen
  • Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen

Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol

FAQs for IL-12 R beta 1 Antibody (AF1998) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Secondary Antibodies


Isotype Controls

Other Available Formats

Biotin BAF1998
Phycoerythrin FAB1998P
Phycoerythrin FAB1998P

Additional IL-12 R beta 1 Products

Bioinformatics Tool for IL-12 R beta 1 Antibody (AF1998)

Discover related pathways, diseases and genes to IL-12 R beta 1 Antibody (AF1998). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Visit Tool

Diseases for IL-12 R beta 1 Antibody (AF1998)

Discover more about diseases related to IL-12 R beta 1 Antibody (AF1998).

Pathways for IL-12 R beta 1 Antibody (AF1998)

View related products by pathway.

PTMs for IL-12 R beta 1 Antibody (AF1998)

Learn more about PTMs related to IL-12 R beta 1 Antibody (AF1998).

Blogs on IL-12 R beta 1

There are no specific blogs for IL-12 R beta 1, but you can read our latest blog posts.

Customers Who Bought This Also Bought

Contact Information

Product PDFs


Concentration Calculator

The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.


Review this Product

Be the first to review our IL-12 R beta 1 Antibody and receive a gift card or discount.


Gene Symbol IL12RB1