IL-12 R beta 1 Products

Description

IL12RB1, also known as Interleukin-12 receptor subunit beta-1, has 3 isoforms, an isoform 1 that is 662 amino acid and 73 kDa, an isoform 2 that is 660 amino acid and 73 kDa, and an isoform3 that is 381 amino acid and 42 kDa; acts as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction; forms a functional, high affinity receptor for IL12 when combined with IL12RB2, and associates also with IL23R to form the interleukin-23 receptor which plays a role in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade. Current research is being pursued on this protein involvement in several diseases and disorders including immunodeficiency, mycobacterial and salmonella infections, salmonella gastroenteritis, mycobacterium infectious disease, myocarditis, lupus erythematosus, tuberculosis, sarcoidosis, neurological disorder, rheumatoid arthritis, gastroenteritis, asthma, and dermatitis. IL12RB1 protein involvement has been observed with relation to IL23R, IL23A, IL12A, IL12B, and IL12RB2 in the immune response IL-12 signaling pathway, immune response IL-22 signaling pathway, immune response IL-12-induced IFN-gamma production, cytokine production by Th17 cells in CF, and Jak-STAT signaling pathway.

Bioinformatics

Entrez	3594 Human
Uniprot	AAH29121 Human AAH29121.1 Human NM_153701 Human NP_005526 Human NP_005526.1 Human P42701 Human
Product By Gene ID	3594
Alternate Names	CD212 antigen CD212 IL-12 receptor beta component IL-12 receptor subunit beta-1 IL-12R subunit beta-1 IL12R IL12RB IL-12RB1 IL-12R-BETA1 IL-12R-beta-1 interleukin 12 receptor, beta 1 interleukin-12 receptor beta-1 chain interleukin-12 receptor subunit beta-1 MGC34454

Research Areas for IL-12 R beta 1

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Cell Cycle and Replication