IIGP1 Antibody

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Western Blot: IIGP1 Antibody [NBP2-03970] - Analysis of Iigp1 using Iigp1 polyclonal antibody. Mouse NIH 3T3 lysate in the absence (A) and presence (B) of immunizing peptide probed with Iigp1 antibody at 4 ug/ml. I goat ...read more

Product Details

Summary
Reactivity Mu, RtSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

IIGP1 Antibody Summary

Immunogen
A portion of amino acids 325-375 of mouse Iigp1 was used as the immunogen for this antibody.
Specificity
This antibody will detect both two isoforms of Iigp1 (413 amino acids and 346 amino acids).
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
Iigp1
Purity
Protein A purified
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Applications/Dilutions

Dilutions
  • Western Blot 3-5 ug/ml

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
0.2 ml PBS and 0.05% BSA
Preservative
0.05% Sodium Azide
Purity
Protein A purified

Alternate Names for IIGP1 Antibody

  • 2900074L10Rik
  • AI046432
  • AW111922
  • Ifgga1
  • Iigp
  • Iigp1
  • Irga6

Background

Iigp1 (Interferon Inducible GTPase1) was first characterized as one of over 500 genes activated in response to Interferon g. Iigp1 is a 47kDa protein part of the GTPase1 family. Iigp1 demonstrates similar micro-molar nucleotide affinities and oligomerization-dependent hydrolytic activity with human GTPase hGBP1, 67-kDa GTPase (induced by type I and type II interferons) and with the antiviral Mx proteins (interferon type I-induced) (Boehm, 1998, Uthaiah, 2003). Binding affinity for Iigp1 is preferential for GDP rather than GTP. Induction of Iigp1 by poly I:C, a TLR3 ligand and interferon inducer, highlights the involvement of TLR3 signaling pathway. Iigp1 is under transcriptional control of IRF-1, a major pathway and indicator of the involvement of TRIF as the main adaptor molecule for TLR3 and Innate Immune signaling pathways in antiviral responses. Iigp1 functions as a mediator of bacterial resistance especially to intracellular pathogens including bacteria and viruses.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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Product General Protocols

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Video Protocols

WB Video Protocol

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Bioinformatics

Gene Symbol Iigp1
Uniprot