IIGP1 Antibody - BSA Free

Western Blot: IIGP1 Antibody [NBP2-03970] - Analysis of Iigp1 using Iigp1 polyclonal antibody. Mouse NIH 3T3 lysate in the absence (A) and presence (B) of immunizing peptide probed with Iigp1 antibody at 4 ug/ml. I goat anti-rabbit Ig HRP secondary antibody and PicoTect ECL substrate solution were used for this test.

• Reactivity: Mu, Rt
• Applications: WB
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 1.0 mg/ml

IIGP1 Antibody - BSA Free Summary

• Description: Novus Biologicals Rabbit IIGP1 Antibody - BSA Free (NBP2-03970) is a polyclonal antibody validated for use in WB. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: A portion of amino acids 325-375 of mouse Iigp1 was used as the immunogen for this antibody.
• Specificity: This antibody will detect both two isoforms of Iigp1 (413 amino acids and 346 amino acids).
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: Iigp1
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Western Blot 3-5 ug/ml

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.05% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Protein A purified

Alternate Names for IIGP1 Antibody - BSA Free

• 2900074L10Rik
• AI046432
• AW111922
• Ifgga1
• Iigp
• Iigp1
• Irga6

Background

Iigp1 (Interferon Inducible GTPase1) was first characterized as one of over 500 genes activated in response to Interferon g. Iigp1 is a 47kDa protein part of the GTPase1 family. Iigp1 demonstrates similar micro-molar nucleotide affinities and oligomerization-dependent hydrolytic activity with human GTPase hGBP1, 67-kDa GTPase (induced by type I and type II interferons) and with the antiviral Mx proteins (interferon type I-induced) (Boehm, 1998, Uthaiah, 2003). Binding affinity for Iigp1 is preferential for GDP rather than GTP. Induction of Iigp1 by poly I:C, a TLR3 ligand and interferon inducer, highlights the involvement of TLR3 signaling pathway. Iigp1 is under transcriptional control of IRF-1, a major pathway and indicator of the involvement of TRIF as the main adaptor molecule for TLR3 and Innate Immune signaling pathways in antiviral responses. Iigp1 functions as a mediator of bacterial resistance especially to intracellular pathogens including bacteria and viruses.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: Iigp1
• Uniprot:
  • NP_068564.4(Mouse)