IgA Antibody (A909)

Product Discontinued

IgA Antibody (A909) Summary

• Immunogen: IgA from human colostrum.
• Localization: Secreted
• Specificity: Pan IgA.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: IGHA1
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Sandwich ELISA 1:100-1:2000
  • Western Blot 1:100-1:2000
• Application Notes: Recommended pairs for the detection of total IgA (pan IgA) (capture - detection): NB110-8343 - NB110-8340, NB110-8342 - NB110-8343

Reactivity Notes

Not yet tested in other species.

Packaging, Storage & Formulations

• Storage: Store at 4C. Do not freeze.
• Buffer: PBS (pH 7.4)
• Preservative: 0.09% Sodium Azide
• Purity: Protein G purified

Alternate Names for IgA Antibody (A909)

• IgA
• Immunoglobulin A

Background

Human IgA (immunoglobulin A) is a glycosylated protein of 160 kDa and is produced as a monomer or as a J chain linked dimer. Monomeric IgA constitutes 5-15 % of the serum immunoglobulins whereas dimeric IgA is localized to mucosa surfaces such as saliva, gastrointestinal secretion, bronchial fluids and milk. Mucosal IgA plays a major role in host defence by neutralising infectious agents at mucosal surfaces. The production is usually local and antigen specific IgA producing B cells can be found in regions under the lamina propria where they mature into dimeric IgA producing plasma cells. IgA deficiency is the most common immunodeficiency that may affect both serum and mucosal produced IgA.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: IGHA1