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IgA Antibody (3B7cc)

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Summary
Product Discontinued
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    • Catalog Number
      NB110-8342
    • Availability
      Product Discontinued

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IgA Antibody (3B7cc) Summary

Immunogen
Hybridoma clones have been derived from hybridization of Sp2/0 myeloma cells with spleen cells of Balb/c mice immunized with IgA from human colostrum.
Localization
Secreted
Specificity
IgA Fc region
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
IGHA1
Purity
Protein A purified
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Applications/Dilutions

Dilutions
  • Haemagglutination
  • Immunodiffusion
  • Sandwich ELISA 1:100-1:2000
  • Western Blot
Application Notes
Recommended for pairs for the detection of total IgA (coating - conjugate): NB110-8342 - NB110-8340, NB110-8342 - NB110-8343. Use in Western blot reported in reported in scientific literature (PMID: 30687320).
Publications
Read Publication using
NB110-8342 in the following applications:

  • WB
    1 publication

Reactivity Notes

Mouse reactivity reported in scientific literature (PMID: 30687320).

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
PBS (pH 7.4)
Preservative
0.09% Sodium Azide
Purity
Protein A purified

Alternate Names for IgA Antibody (3B7cc)

  • IgA
  • Immunoglobulin A

Background

Human IgA (immunoglobulin A) is a glycosylated protein of 160 kDa and is produced as a monomer or as a J chain linked dimer. Monomeric IgA constitutes 5-15 % of the serum immunoglobulins whereas dimeric IgA is localized to mucosa surfaces such as saliva, gastrointestinal secretion, bronchial fluids and milk. Mucosal IgA plays a major role in host defence by neutralising infectious agents at mucosal surfaces. The production is usually local and antigen specific IgA producing B cells can be found in regions under the lamina propria where they mature into dimeric IgA producing plasma cells. IgA deficiency is the most common immunodeficiency that may affect both serum and mucosal produced IgA.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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IgA Antibody
(3B7cc)
NB110-8342
IgA Antibody (3B7cc)
Species: Hu, Mu
Applications: WB, ELISA, Func

Publications for IgA Antibody (NB110-8342)(1)

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: WB.


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Understanding the Importance of Human IgG
Human IgG is a component of the immune system that protects the body from infection. It is the most abundantly found antibody isotype within the circulatory system of the human body. All antibody isotypes contain two heavy chains and two light chains ...  Read full blog post.

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Bioinformatics

Gene Symbol IGHA1
Entrez
Uniprot